Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats.

abstract：:Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes. This study sought to determine the effects of age and vitamin E supplementation in the form of tocotrienol-rich fraction (TRF) on brain arginine metabolism. Male Wistar rats at ages of 3 and 21 mon...

journal_title：Oxidative medicine and cellular longevity

authors： Mazlan M,Hamezah HS,Taridi NM,Jing Y,Liu P,Zhang H,Wan Ngah WZ,Damanhuri HA

更新日期：2017-01-01 00:00:00

abstract：:Barley grass powder is the best functional food that provides nutrition and eliminates toxins from cells in human beings; however, its functional ingredients have played an important role as health benefit. In order to better cognize the preventive and therapeutic role of barley grass for chronic diseases, we carried ...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng Y,Pu X,Yang J,Du J,Yang X,Li X,Li L,Zhou Y,Yang T

更新日期：2018-04-04 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a great socioeconomic burden in the aging society. Compelling evidence demonstrates that molecular change characteristics for AD, such as oxidative stress and amyloid β (Aβ) oligomerization, precede by decades the onset of clinical dementia and that the...

journal_title：Oxidative medicine and cellular longevity

authors： Wojsiat J,Zoltowska KM,Laskowska-Kaszub K,Wojda U

更新日期：2018-01-31 00:00:00

abstract：Objective:Atherogenic lipoproteins may impair vascular reactivity consecutively causing tissue damage in multiple organs via abnormal perfusion and excessive reactive oxygen species generation. We tested the hypothesis that chronic hypercholesterolemia causes endothelial dysfunction and cell loss in the retina. Method...

journal_title：Oxidative medicine and cellular longevity

authors： Zadeh JK,Zhutdieva MB,Laspas P,Yuksel C,Musayeva A,Pfeiffer N,Brochhausen C,Oelze M,Daiber A,Xia N,Li H,Gericke A

更新日期：2019-11-12 00:00:00

abstract：:Exposure to ionizing radiation alone (RI) or combined with traumatic tissue injury (CI) is a crucial life-threatening factor in nuclear and radiological events. In our laboratory, mice exposed to (60)Co-γ-photon radiation (9.5 Gy, 0.4 Gy/min, bilateral) followed by 15% total-body-surface-area skin wounds (R-W CI) or b...

journal_title：Oxidative medicine and cellular longevity

authors： Kiang JG,Zhai M,Liao PJ,Elliott TB,Gorbunov NV

更新日期：2014-01-01 00:00:00

abstract：:Mitochondria are the primary site of cellular energy generation and reactive oxygen species (ROS) accumulation. Elevated ROS levels are detrimental to normal cell function and have been linked to the pathogenesis of neurodegenerative disorders such as Down's syndrome (DS) and Alzheimer's disease (AD). RCAN1 is abundan...

journal_title：Oxidative medicine and cellular longevity

authors： Peiris H,Dubach D,Jessup CF,Unterweger P,Raghupathi R,Muyderman H,Zanin MP,Mackenzie K,Pritchard MA,Keating DJ

更新日期：2014-01-01 00:00:00

abstract：:Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial...

journal_title：Oxidative medicine and cellular longevity

authors： Tan S,Wong E

更新日期：2017-01-01 00:00:00

abstract：Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

更新日期：2019-04-16 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneratio...

journal_title：Oxidative medicine and cellular longevity

authors： Khan MS,Muhammad T,Ikram M,Kim MO

更新日期：2019-11-07 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：:A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular ...

journal_title：Oxidative medicine and cellular longevity

authors： Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VI

更新日期：2018-01-31 00:00:00

abstract：:The clinical and experimental postcardiac arrest treatment has not reached therapeutic success. The present study investigated the effect of PD98059 (PD) in rats subjected to cardiac arrest (CA)/cardiopulmonary resuscitation (CPR). Experimental rats were divided randomly into 3 groups: sham, CA, and PD. The rats excep...

journal_title：Oxidative medicine and cellular longevity

authors： Nguyen Thi PA,Chen MH,Li N,Zhuo XJ,Xie L

更新日期：2016-01-01 00:00:00

abstract：:The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

journal_title：Oxidative medicine and cellular longevity

authors： Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

更新日期：2015-01-01 00:00:00

abstract：:We investigated the gender differences in heme-oxygenase (HO) enzyme, which produces endogenous vascular protective carbon monoxide (CO). We studied (1) the activity and expression of HO enzymes in the left ventricle (LV) and aorta, (2) basal increase in basal blood pressure provoked by arginine vasopressine (AVP) in ...

journal_title：Oxidative medicine and cellular longevity

authors： Pósa A,Kupai K,Ménesi R,Szalai Z,Szabó R,Pintér Z,Pálfi G,Gyöngyösi M,Berkó A,Pávó I,Varga C

更新日期：2013-01-01 00:00:00

abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%. However, the disease mechanism remains unclear, and no effective treatment is available. Paricalcitol has been reported to be effective in animal models of kidney injury. We hypoth...

journal_title：Oxidative medicine and cellular longevity

authors： Bae E,Kim JH,Jung MH,Jang SJ,Lee TW,Jung S,Lee S,Jang HN,Chang SH,Park DJ

更新日期：2020-11-23 00:00:00

abstract：:Respiratory diseases are accompanied by intensification of free radical processes at different levels of the biological body organization. Simultaneous stress and suppression of various parts of antioxidant protection lead to the development of oxidative stress (OS) and nitrosative stress (NS). The basic mechanisms of...

journal_title：Oxidative medicine and cellular longevity

authors： Soodaeva S,Kubysheva N,Klimanov I,Nikitina L,Batyrshin I

更新日期：2019-05-22 00:00:00

abstract：:The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory ...

journal_title：Oxidative medicine and cellular longevity

authors： Hassanein EHM,Sayed AM,Hussein OE,Mahmoud AM

更新日期：2020-04-22 00:00:00

abstract：:Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might ...

journal_title：Oxidative medicine and cellular longevity

authors： Petruk G,Del Giudice R,Rigano MM,Monti DM

更新日期：2018-08-02 00:00:00

abstract：:Choroidal neovascularization (CNV) is a sight-threatening disease and is characterized by the formation of pathological neovascularization in the choroid which extends into the subretinal space. Exudative age-related macular degeneration (AMD) is the formation of CNV in the macular area which leads to irreversible bli...

journal_title：Oxidative medicine and cellular longevity

authors： Xi L

更新日期：2020-03-06 00:00:00

abstract：:Oxidative stress (OS) and neuronal apoptosis are major pathological processes after hypoxic-ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to CSF1 receptor (CSF1R), has been shown to reduce neuronal loss after hypoxic-ischemia- (HI-) induced brain injury. In the present study, we hypothesiz...

journal_title：Oxidative medicine and cellular longevity

authors： Hu X,Li S,Doycheva DM,Huang L,Lenahan C,Liu R,Huang J,Gao L,Tang J,Zuo G,Zhang JH

更新日期：2020-10-07 00:00:00

abstract：:Oxidative stress is involved in pathophysiology and pathological conditions of numerous human diseases. Thus, understanding the mechanisms underlying the redox homeostasis in cells and organs is valuable for discovery of therapeutic drugs for oxidative stress-related diseases. Recently, by applying chemical biology ap...

journal_title：Oxidative medicine and cellular longevity

authors： Yukitake H,Takizawa M,Kimura H

更新日期：2017-01-01 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a ce...

journal_title：Oxidative medicine and cellular longevity

authors： Büchter C,Zhao L,Havermann S,Honnen S,Fritz G,Proksch P,Wätjen W

更新日期：2015-01-01 00:00:00

abstract：:Fibroblasts are essential for tissue repair due to producing collagens, and lysosomal proteinase cathepsin B (CatB) is involved in promoting chronic inflammation. We herein report that CatB regulates the expression of collagens III and IV by fibroblasts in response to a TLR2 agonist, lipopolysaccharide from Porphyromo...

journal_title：Oxidative medicine and cellular longevity

authors： Li X,Wu Z,Ni J,Liu Y,Meng J,Yu W,Nakanishi H,Zhou Y

更新日期：2016-01-01 00:00:00

abstract：:The widely used herbicide atrazine (ATR) can cause many adverse effects including immunotoxicity, but the underlying mechanisms are not fully understood. The current study investigated the role of oxidative stress and calcium homeostasis in ATR-induced immunotoxicity in mice. ATR at doses of 0, 100, 200, or 400 mg/kg ...

journal_title：Oxidative medicine and cellular longevity

authors： Gao S,Wang Z,Zhang C,Jia L,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：Background:Oxidized human DNA or plasmid DNAs containing human ribosomal genes can easily penetrate into the breast cancer cells MCF7 and stimulate the adaptive response induction. Plasmid DNA containing a CMV promoter, gene EGFP, and the insertion of the human ribosomal genes can be expressed. A hypothesis is proposed...

journal_title：Oxidative medicine and cellular longevity

authors： Kozhina EA,Ershova ES,Okorokova NA,Veiko VP,Malinovskaya EM,Sergeeva VA,Konkova MS,Kutsev SI,Veiko NN,Kostyuk SV

更新日期：2019-11-03 00:00:00

abstract：:The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin. Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months. At the end of 3-month SFN treatment, the diabeti...

journal_title：Oxidative medicine and cellular longevity

authors： Cui W,Bai Y,Miao X,Luo P,Chen Q,Tan Y,Rane MJ,Miao L,Cai L

更新日期：2012-01-01 00:00:00

abstract：:Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccha...

journal_title：Oxidative medicine and cellular longevity

authors： Giancaspero TA,Locato V,Barile M

更新日期：2013-01-01 00:00:00

abstract：:In plasma medicine, cold physical plasma delivers a delicate mixture of reactive components to cells and tissues. Recent studies suggested a beneficial role of cold plasma in wound healing. Yet, the biological processes related to the redox modulation via plasma are not fully understood. We here used the monocytic cel...

journal_title：Oxidative medicine and cellular longevity

authors： Bekeschus S,Schmidt A,Bethge L,Masur K,von Woedtke T,Hasse S,Wende K

更新日期：2016-01-01 00:00:00

abstract：:A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies. As red blood cells (RBCs) participate in NO formation in the bloodstream, the aim of this study was to outline the metabolic profile of L-arginine (Arg)/NO pathway and of oxidati...

journal_title：Oxidative medicine and cellular longevity

authors： Porro B,Eligini S,Veglia F,Lualdi A,Squellerio I,Fiorelli S,Giovannardi M,Chiorino E,Dalla Cia A,Crisci M,Werba JP,Tremoli E,Cavalca V

更新日期：2014-01-01 00:00:00