Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes.

abstract：:Tilia genus is commonly used around the world for its central nervous system properties; it is prepared as tea and used as tranquilizing, anticonvulsant, and analgesic. In this study, anticonvulsant activity of the Tilia americana var. mexicana inflorescences and leaves was investigated by evaluating organic and aqueo...

journal_title：Oxidative medicine and cellular longevity

authors： Cárdenas-Rodríguez N,González-Trujano ME,Aguirre-Hernández E,Ruíz-García M,Sampieri A 3rd,Coballase-Urrutia E,Carmona-Aparicio L

更新日期：2014-01-01 00:00:00

abstract：:We recently showed that combination therapy with losartan and pioglitazone provided synergistic effects compared with monotherapy in improving lesions of renal structure and function in Sprague-Dawley rats fed with a high-fat, high-sodium diet and 20% sucrose solution. This study was designed to explore the underlying...

journal_title：Oxidative medicine and cellular longevity

authors： Kong X,Zhang Y,Wu HB,Li FX,Zhang DY,Su Q

更新日期：2012-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated mole...

journal_title：Oxidative medicine and cellular longevity

authors： Fawzy MS,Badran DI,Al Ageeli E,Al-Qahtani SAM,Alghamdi SA,Helal GM,Toraih EA

更新日期：2018-03-21 00:00:00

abstract：OBJECTIVES:The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS:The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Lau RC,Bennett RD

更新日期：2017-01-01 00:00:00

abstract：:Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) aft...

journal_title：Oxidative medicine and cellular longevity

authors： Gaastra B,Glazier J,Bulters D,Galea I

更新日期：2017-01-01 00:00:00

abstract：:Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticanc...

journal_title：Oxidative medicine and cellular longevity

authors： Li K,Zheng Q,Chen X,Wang Y,Wang D,Wang J

更新日期：2018-10-16 00:00:00

abstract：:The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generat...

journal_title：Oxidative medicine and cellular longevity

authors： Aune SE,Yeh ST,Kuppusamy P,Kuppusamy ML,Khan M,Angelos MG

更新日期：2013-01-01 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species. In addition to this housekeeping function, mammalian XOR is a physiological source of superoxide ion, hydrogen peroxide, and nitric oxide, which can fu...

journal_title：Oxidative medicine and cellular longevity

authors： Battelli MG,Polito L,Bortolotti M,Bolognesi A

更新日期：2016-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus ...

journal_title：Oxidative medicine and cellular longevity

authors： Liu J,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:Oleuropein (OP) is a bioactive compound derived from plants of the genus Oleaceae exhibiting antitumor properties in several human cancers, including non-small-cell lung cancer (NSCLC). Recent evidence suggests that OP has proapoptotic effects on NSCLC cells via the mitochondrial apoptotic pathway. However, the exact ...

journal_title：Oxidative medicine and cellular longevity

authors： Antognelli C,Frosini R,Santolla MF,Peirce MJ,Talesa VN

更新日期：2019-07-22 00:00:00

abstract：Objectives:Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery. Method...

journal_title：Oxidative medicine and cellular longevity

authors： Li CX,Wang HW,Jiang WJ,Li GC,Zhang YD,Luo CH,Li XC

更新日期：2020-02-27 00:00:00

abstract：:Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However, the specific effects of ISL on AP have not been determined. In this study, we aimed to investigate the protective effect of ISL on AP using ...

journal_title：Oxidative medicine and cellular longevity

authors： Liu X,Zhu Q,Zhang M,Yin T,Xu R,Xiao W,Wu J,Deng B,Gao X,Gong W,Lu G,Ding Y

更新日期：2018-04-26 00:00:00

abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

journal_title：Oxidative medicine and cellular longevity

authors： Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

更新日期：2020-02-12 00:00:00

abstract：:Fisetin, a known antioxidant, has been found to be cytotoxic against certain cell lines. However, the mechanism by which it inhibits tumor growth in vivo remains unexplored. Recently, we have demonstrated that Aflatoxin-B1 (AFB1) induced hepatocarcinogenesis is associated with activation of oxidative stress-inflammato...

journal_title：Oxidative medicine and cellular longevity

authors： Maurya BK,Trigun SK

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries i...

journal_title：Oxidative medicine and cellular longevity

authors： Yan C,Zhang X,Miao J,Yuan H,Liu E,Liang T,Li Q

更新日期：2020-01-28 00:00:00

abstract：Background:Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure. Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury. Intravenous anesthetic propofol potent effects on free radical scaven...

journal_title：Oxidative medicine and cellular longevity

authors： Yao W,Han X,Zhang Y,Guan J,Ge M,Chen C,Wu S,Chen J,Luo G,Huang P,Hei Z

更新日期：2018-10-28 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. R...

journal_title：Oxidative medicine and cellular longevity

authors： Lv P,Chen T,Liu P,Zheng L,Tian J,Tan F,Chen J,Deng Y,Li J,Cai J,Chi X

更新日期：2019-11-11 00:00:00

abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

journal_title：Oxidative medicine and cellular longevity

authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic ef...

journal_title：Oxidative medicine and cellular longevity

authors： Ficarra S,Russo A,Barreca D,Giunta E,Galtieri A,Tellone E

更新日期：2016-01-01 00:00:00

abstract：:Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of ...

journal_title：Oxidative medicine and cellular longevity

authors： Maciejczyk M,Skutnik-Radziszewska A,Zieniewska I,Matczuk J,Domel E,Waszkiel D,Żendzian-Piotrowska M,Szarmach I,Zalewska A

更新日期：2019-03-10 00:00:00

abstract：:Degradation of oxidized or oxidatively modified proteins is an essential part of the antioxidant defenses of cells. 4-Hydroxy-2-nonenal, a major reactive aldehyde formed by lipid peroxidation, causes many types of cellular damage. It has been reported that 4-hydroxy-2-nonenal-modified proteins are degraded by the ubiq...

journal_title：Oxidative medicine and cellular longevity

authors： Tsuchiya Y,Okada G,Kobayashi S,Chikuma T,Hojo H

更新日期：2011-01-01 00:00:00

abstract：:Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

journal_title：Oxidative medicine and cellular longevity

authors： Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

更新日期：2019-02-17 00:00:00

abstract：:Doxorubicin (DOX) is a broad-spectrum antitumor drug while its use is limited due to its neurobiological side effects associated with depression. We investigated the neuroprotective efficacy of dl-3-n-butylphthalide (dl-NBP) against DOX-induced anxiety- and depression-like behaviors in rats. dl-NBP was given (30 mg/kg...

journal_title：Oxidative medicine and cellular longevity

authors： Liao D,Xiang D,Dang R,Xu P,Wang J,Han W,Fu Y,Yao D,Cao L,Jiang P

更新日期：2018-08-16 00:00:00

abstract：:Mitochondrial dysfunction is associated with macrophage damage, but the role of mitochondrial fission in macrophage cholesterol metabolism is not fully understood. In this study, we explored the influences of miR-9 and mitochondrial fission on macrophage viability and cholesterol metabolism. Macrophages were incubated...

journal_title：Oxidative medicine and cellular longevity

authors： Xin T,Lu C,Zhang J,Wen J,Yan S,Li C,Zhang F,Zhang J

更新日期：2020-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regu...

journal_title：Oxidative medicine and cellular longevity

authors： Chu Q,Zhang S,Chen M,Han W,Jia R,Chen W,Zheng X

更新日期：2019-02-25 00:00:00

abstract：:OVE26 mice are a widely used transgenic model of early-onset type 1 diabetes. These mice overexpress calmodulin in their pancreatic β cells, develop severe diabetes within the first weeks of life, and progress to severe diabetic complications including diabetic nephropathy and diabetic cardiomyopathy (DCM). To date, d...

journal_title：Oxidative medicine and cellular longevity

authors： Tang X,Jiang S,Zhang J,Zhou S,Zheng Y

更新日期：2020-05-14 00:00:00

abstract：:An optimisation of extraction towards an increased antioxidant capacity and the study on the extracts' composition by HPLC-ESI-Q-TOF-MS were performed on different organs of a rarely studied plant: Rheum cordatum Losinsk (Polygonaceae) growing in Kazakhstan. More than 20 compounds from anthraquinones and phenolics wer...

journal_title：Oxidative medicine and cellular longevity

authors： Zhumashova G,Kukula-Koch W,Koch W,Baj T,Sayakova G,Shukirbekova A,Głowniak K,Sakipova Z

更新日期：2019-11-16 00:00:00

abstract：:Andrographolide (Andro), a major bioactive component obtained from Andrographis paniculata Nees, has exerted wide antioxidant as well as cytoprotective properties. However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) remains unknown. In this study, we evaluated the effects of And...

journal_title：Oxidative medicine and cellular longevity

authors： Liang E,Liu X,Du Z,Yang R,Zhao Y

更新日期：2018-06-25 00:00:00