Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis.

Abstract:

:Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of AP rats. Male Wistar rats were divided equally into 2 groups: control (n = 9) and AP (n = 9). AP was induced by intraperitoneal injection with cerulein and confirmed by higher serum amylase and lipase. We have demonstrated that the superoxide dismutase and glutathione reductase activities, as well as reduced glutathione concentration, were significantly decreased in both the parotid and submandibular glands of AP rats as compared to the control rats. The production of free radicals evidenced as dichlorodihydrofluorescein assay and the activity of NADPH oxidase and xanthine oxidase and IL-1β concentration were significantly higher in the parotid and submandibular glands of AP rats compared to the controls. In AP rats, we also showed a statistical increase in oxidation modification products (advanced glycation end products and advanced oxidation protein products), salivary amylase activity, and significant decrease in the total protein content. However, we did not show apoptosis and any morphological changes in the histological examination of the salivary glands of AP rats. To sum up, cerulein-induced AP intensifies production of oxygen free radicals, impairs the redox balance of the salivary glands, and is responsible for higher oxidative damage to these glands. Interestingly, oxidative modification of proteins and dysfunction of the antioxidant barrier are more pronounced in the submandibular glands of AP rats.

journal_name

Oxid Med Cell Longev

authors

Maciejczyk M,Skutnik-Radziszewska A,Zieniewska I,Matczuk J,Domel E,Waszkiel D,Żendzian-Piotrowska M,Szarmach I,Zalewska A

doi

10.1155/2019/8403578

subject

Has Abstract

pub_date

2019-03-10 00:00:00

pages

8403578

eissn

1942-0900

issn

1942-0994

journal_volume

2019

pub_type

杂志文章
  • The Antiaggregative and Antiamyloidogenic Properties of Nanoparticles: A Promising Tool for the Treatment and Diagnostics of Neurodegenerative Diseases.

    abstract::Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies. They...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3534570

    authors: Pichla M,Bartosz G,Sadowska-Bartosz I

    更新日期:2020-10-13 00:00:00

  • An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia.

    abstract::In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole webs...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/9162074

    authors: Liu M,Tang L,Liu X,Fang J,Zhan H,Wu H,Yang H

    更新日期:2016-01-01 00:00:00

  • Oxidized LDL Disrupts Metabolism and Inhibits Macrophage Survival by Activating a miR-9/Drp1/Mitochondrial Fission Signaling Pathway.

    abstract::Mitochondrial dysfunction is associated with macrophage damage, but the role of mitochondrial fission in macrophage cholesterol metabolism is not fully understood. In this study, we explored the influences of miR-9 and mitochondrial fission on macrophage viability and cholesterol metabolism. Macrophages were incubated...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/8848930

    authors: Xin T,Lu C,Zhang J,Wen J,Yan S,Li C,Zhang F,Zhang J

    更新日期:2020-11-01 00:00:00

  • Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy.

    abstract::Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9028435

    authors: Tan S,Wong E

    更新日期:2017-01-01 00:00:00

  • Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke.

    abstract::We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS). 82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B)...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/9761697

    authors: Žitňanová I,Šiarnik P,Kollár B,Chomová M,Pazderová P,Andrezálová L,Ježovičová M,Koňariková K,Laubertová L,Krivošíková Z,Slezáková L,Turčáni P

    更新日期:2016-01-01 00:00:00

  • Antioxidants from Plants Protect against Skin Photoaging.

    abstract::Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2018/1454936

    authors: Petruk G,Del Giudice R,Rigano MM,Monti DM

    更新日期:2018-08-02 00:00:00

  • Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments.

    abstract::2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascu...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/4973239

    authors: Ling S,Xu JW

    更新日期:2016-01-01 00:00:00

  • Deleterious effects of reactive metabolites.

    abstract::A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected toxicities that become apparent only after the launch of new drug entities. Circumstantial evidence suggests that, in most cases, reactive metabolites are responsible for these unexpected toxicities. In this...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.4161/oxim.3.4.13246

    authors: Attia SM

    更新日期:2010-07-01 00:00:00

  • Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta.

    abstract::The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/3939540

    authors: Palacios J,Cifuentes F,Valderrama JA,Benites J,Ríos D,González C,Chiong M,Cartes-Saavedra B,Lafourcade C,Wyneken U,González P,Owen GI,Pardo F,Sobrevia L,Buc Calderon P

    更新日期:2016-01-01 00:00:00

  • Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.

    abstract::Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign lipid storage to so-called second hit of inflammation activation. Isoquercitrin (IQ) is widely present flavonoid but its effects on hepatic lipid metabolism remain unknown. We used free fatty acids (FFA) induced lipid overl...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2014/313602

    authors: Hassan W,Rongyin G,Daoud A,Ding L,Wang L,Liu J,Shang J

    更新日期:2014-01-01 00:00:00

  • Thiol redox sensitivity of two key enzymes of heme biosynthesis and pentose phosphate pathways: uroporphyrinogen decarboxylase and transketolase.

    abstract::Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP). The redox properties of both Hem12p and Tkl1p from Saccharomyces cerevisiae were investigated using proteom...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/932472

    authors: McDonagh B,Pedrajas JR,Padilla CA,Bárcena JA

    更新日期:2013-01-01 00:00:00

  • PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model.

    abstract::The clinical and experimental postcardiac arrest treatment has not reached therapeutic success. The present study investigated the effect of PD98059 (PD) in rats subjected to cardiac arrest (CA)/cardiopulmonary resuscitation (CPR). Experimental rats were divided randomly into 3 groups: sham, CA, and PD. The rats excep...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/3723762

    authors: Nguyen Thi PA,Chen MH,Li N,Zhuo XJ,Xie L

    更新日期:2016-01-01 00:00:00

  • Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles.

    abstract:Objective:Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated in...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9736047

    authors: Gericke A,Mann C,Zadeh JK,Musayeva A,Wolff I,Wang M,Pfeiffer N,Daiber A,Li H,Xia N,Prokosch V

    更新日期:2019-12-29 00:00:00

  • Protective Function of Novel Fungal Immunomodulatory Proteins Fip-lti1 and Fip-lti2 from Lentinus tigrinus in Concanavalin A-Induced Liver Oxidative Injury.

    abstract::Fungal immunomodulatory proteins (FIPs) are a class of small proteins that have been extensively studied for their immunomodulatory activities. In this study, two novel FIPs from Lentinus tigrinus were identified and named Fip-lti1 and Fip-lti2. The bioactive characteristics of Fip-lti1 and Fip-lti2 were compared to a...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/3139689

    authors: Gao Y,Wáng Y,Wāng Y,Wu Y,Chen H,Yang R,Bao D

    更新日期:2019-05-06 00:00:00

  • Interaction of TPPP3 with VDAC1 Promotes Endothelial Injury through Activation of Reactive Oxygen Species.

    abstract::Endothelial injury plays a critical role in the pathogenesis of cardiovascular disorders and metabolic-associated vascular complications which are the leading cause of death worldwide. However, the mechanism underlying endothelial dysfunction is not completely understood. The study is aimed at investigating the role o...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/5950195

    authors: Liu N,Li Y,Nan W,Zhou W,Huang J,Li R,Zhou L,Hu R

    更新日期:2020-10-02 00:00:00

  • The Degree of Helicobacter pylori Infection Affects the State of Macrophage Polarization through Crosstalk between ROS and HIF-1α.

    abstract:Methods:The expression of CD86, CD206, and HIF-1α in the gastric mucosa was evaluated through immunohistochemistry. RAW 264.7 cells were cocultured with H. pylori at various multiplicities of infection (MOIs), and iNOS, CD86, Arg-1, CD206, and HIF-1α expression was detected by Western blot, PCR, and ELISA analyses. ROS...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/5281795

    authors: Lu Y,Rong J,Lai Y,Tao L,Yuan X,Shu X

    更新日期:2020-12-08 00:00:00

  • The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids.

    abstract::Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated w...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/3789856

    authors: Baldim JL,de Alcântara BGV,Domingos ODS,Soares MG,Caldas IS,Novaes RD,Oliveira TB,Lago JHG,Chagas-Paula DA

    更新日期:2017-01-01 00:00:00

  • 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.

    abstract::Ulcerative colitis (UC) is a common inflammatory bowel disease that can destroy the integrity of the colon and increase the risk of colorectal cancer. Oxidative stress is one of the critical pathogenic factors for UC, further impairing the entire affected colon. The Nrf2-ARE signaling pathway plays an important role i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/3271617

    authors: Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

    更新日期:2018-05-20 00:00:00

  • The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism.

    abstract:Objectives:Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery. Method...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/3076131

    authors: Li CX,Wang HW,Jiang WJ,Li GC,Zhang YD,Luo CH,Li XC

    更新日期:2020-02-27 00:00:00

  • Neuroprotective Effects of dl-3-n-Butylphthalide against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes.

    abstract::Doxorubicin (DOX) is a broad-spectrum antitumor drug while its use is limited due to its neurobiological side effects associated with depression. We investigated the neuroprotective efficacy of dl-3-n-butylphthalide (dl-NBP) against DOX-induced anxiety- and depression-like behaviors in rats. dl-NBP was given (30 mg/kg...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/9125601

    authors: Liao D,Xiang D,Dang R,Xu P,Wang J,Han W,Fu Y,Yao D,Cao L,Jiang P

    更新日期:2018-08-16 00:00:00

  • Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury.

    abstract::Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial. To explore these issues, we created an SCIR injury rat model via aortic a...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/8640284

    authors: Xie L,Yu S,Yang K,Li C,Liang Y

    更新日期:2017-01-01 00:00:00

  • Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation.

    abstract::We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either plac...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/2840643

    authors: Sakelliou A,Fatouros IG,Athanailidis I,Tsoukas D,Chatzinikolaou A,Draganidis D,Jamurtas AZ,Liacos C,Papassotiriou I,Mandalidis D,Stamatelopoulos K,Dimopoulos MA,Mitrakou A

    更新日期:2016-01-01 00:00:00

  • Use of Carnosine for Oxidative Stress Reduction in Different Pathologies.

    abstract::The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies are presented. Special attention is paid to issues of use of carnosine in neurologic and mental diseases, in alcoholism as...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2939087

    authors: Prokopieva VD,Yarygina EG,Bokhan NA,Ivanova SA

    更新日期:2016-01-01 00:00:00

  • Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury.

    abstract::Ischemia-reperfusion (I/R) injury caused by acute myocardial infarction (AMI) can initiate a strong inflammatory response. Polymorphonuclear cells (PMNs) are the most important inflammatory cells. Our previous studies found that the calcium-sensing receptor (CaSR) regulates the proinflammatory effects of PMNs. However...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2021/3010548

    authors: Zhai TY,Cui BH,Zhou Y,Xu XY,Zou L,Lin X,Zhu XS,Zhang SW,Xie WL,Cheng YY,Sun YH

    更新日期:2021-01-12 00:00:00

  • Oxidative Stress and Microvascular Alterations in Diabetic Retinopathy: Future Therapies.

    abstract::Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin. However, patients' metabolic control is inadequate in a high percentage of them and a major cause of chronic diseases like diabetic retinopathy. Approximately 15% of patients have some degree of diabetic retinopathy when diabetes i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2019/4940825

    authors: Rodríguez ML,Pérez S,Mena-Mollá S,Desco MC,Ortega ÁL

    更新日期:2019-11-11 00:00:00

  • Moderate Mechanical Stimulation Protects Rats against Osteoarthritis through the Regulation of TRAIL via the NF-κB/NLRP3 Pathway.

    abstract::The aim of this study was to examine exercise-related genes in articular cartilage identified through bioinformatics analysis to dissect the potential signaling pathway involved in mechanical stimulation in osteoarthritis (OA). To this end, we evaluated the GSE74898 dataset from the Gene Expression Omnibus database fo...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/6196398

    authors: Yang Y,Wang Y,Kong Y,Zhang X,Zhang H,Feng X,Wang Z,Gao P,Yan M,Bai L,Li F

    更新日期:2020-05-23 00:00:00

  • Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease.

    abstract::The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2015/842108

    authors: Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

    更新日期:2015-01-01 00:00:00

  • Polyphenols in exercise performance and prevention of exercise-induced muscle damage.

    abstract::Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/825928

    authors: Malaguti M,Angeloni C,Hrelia S

    更新日期:2013-01-01 00:00:00

  • The potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female rats.

    abstract::Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randoml...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/741817

    authors: Dkhil MA,Al-Quraishy S,Aref AM,Othman MS,El-Deib KM,Abdel Moneim AE

    更新日期:2013-01-01 00:00:00

  • Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme.

    abstract::Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated mole...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/8753063

    authors: Fawzy MS,Badran DI,Al Ageeli E,Al-Qahtani SAM,Alghamdi SA,Helal GM,Toraih EA

    更新日期:2018-03-21 00:00:00