Abstract:
:Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in a series of established in vitro tests. Moreover, incorporation of L. paracasei K5 as starter culture offered organoleptic and technological advantages to novel fermented food products. In the present study, further investigation of the potential probiotic activity of L. paracasei K5 was performed and its mechanisms of action were investigated. Employing quantitative analysis and confocal, fluorescent microscopy the adhesion properties of the above strain were studied. L. paracasei K5 displayed efficient adherence capacity to Caco-2 colon cancer cells, similarly to the reference strains Lactobacillus casei ATCC 393 and Lactobacillus rhamnosus GG. Moreover, treatment of Caco-2 cells with L. paracasei K5 inhibited cell proliferation in a time-and dose-dependent manner. The anti-proliferative effects appear to be mediated through induction of apoptosis via modulation of expression of specific Bcl-2 family proteins. These results elucidate the mechanisms of action of L. paracasei K5 and enhance its potential probiotic activity.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Chondrou P,Karapetsas A,Kiousi DE,Tsela D,Tiptiri-Kourpeti A,Anestopoulos I,Kotsianidis I,Bezirtzoglou E,Pappa A,Galanis Adoi
10.3920/BM2017.0183subject
Has Abstractpub_date
2018-12-07 00:00:00pages
975-983issue
6eissn
1876-2883issn
1876-2891journal_volume
9pub_type
杂志文章abstract::The objective of the study was to isolate potential probiotic lactobacilli from Kimere, a pearl millet dough prepared in the Mbeere community of Kenya, East Africa, by fermentation for 18-24 hours. Kimere samples, collected from 11 different homesteads in Mbeere, showed average pH values of 3.63±0.29. Counts of presum...
journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
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journal_title:Beneficial microbes
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pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0029
更新日期:2010-11-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2010.0031
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0044
更新日期:2020-10-12 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
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更新日期:2018-06-15 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0154
更新日期:2015-01-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0021
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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abstract::The gut intestinal tract harbours a complex microbiota. Disturbances in the microbiota composition have been associated with several immune dysfunctions such as inflammatory diseases. Specific strains of probiotics have shown to beneficially influence the composition and/or metabolic activity of the endogenous microbi...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
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