Abstract:
:This study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bifidobacterium only during disease induction (7 days); total treatment (TT) group, mice received Bifidobacterium for 10 days before and during disease induction. The probiotic effects on intestinal permeability, inflammatory infiltrate, histological analysis, cytokines, chemokines and sIgA were evaluated. Bifidobacterium administration in the T group showed reduction in intestinal permeability and lower IL-1β, myeloperoxidase, and eosinophil peroxidase levels compared to those in the colitis group (P<0.05). Bifidobacterium administration in the TT group attenuated severe lesions in the colon and reduced eosinophil peroxidase level (P<0.05). B. longum 51A treatment modality was more effective than total treatment and reduced the inflammatory response and its consequences on intestinal epithelium.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Abrantes FA,Nascimento BB,Andrade MER,de Barros PAV,Cartelle CT,Martins FS,Nicoli JR,Arantes RME,Generoso SV,Fernandes SOA,Cardoso VNdoi
10.3920/BM2019.0098subject
Has Abstractpub_date
2020-02-19 00:00:00pages
47-57issue
1eissn
1876-2883issn
1876-2891journal_volume
11pub_type
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