Abstract:
:The mechanism of neurodegeneration in Parkinson's disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to the neurodegenerative processes. In PD patients as well as in animal models for PD, alpha-synuclein-positive enteric neurons in the colon and evidence of colonic inflammation have been demonstrated. Moreover, several studies reported pro-inflammatory bacterial dysbiosis in PD patients. Here, we report for the first time significant changes in the composition of caecum mucosal associated and luminal microbiota and the associated metabolic pathways in a rotenone-induced mouse model for PD. The mouse model for PD, induced by the pesticide rotenone, is associated with an imbalance in the gut microbiota, characterised by a significant decrease in the relative abundance of the beneficial commensal bacteria genus Bifidobacterium. Overall, intestinal bacterial dysbiosis might play an important role in both the disruption of intestinal epithelial integrity and intestinal inflammation, which could lead or contribute to the observed alpha-synuclein aggregation and PD pathology in the intestine and central nervous system in the oral rotenone mouse model of PD.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Perez-Pardo P,Dodiya HB,Engen PA,Naqib A,Forsyth CB,Green SJ,Garssen J,Keshavarzian A,Kraneveld ADdoi
10.3920/BM2017.0202subject
Has Abstractpub_date
2018-09-18 00:00:00pages
799-814issue
5eissn
1876-2883issn
1876-2891journal_volume
9pub_type
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