Isolation and structural identification of glycopolymers of Bifidobacterium bifidum BIM B-733D as putative players in pathogenesis of autoimmune thyroid diseases.

Abstract:

:Bifidobacterium bifidum 791 (commercially available as B. bifidum BIM B-733D) cell-surface biopolymers (BPs) interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti TPO and anti Tg, respectively). BPanti-TPO and BPanti-Tg were isolated from the soluble fraction of B. bifidum BIM B-733D by affinity chromatography with anti-TPO or anti-Tg, respectively. Homogeneity of affinity eluates (AEanti-TPO and AEanti-Tg) was tested by size exclusion chromatography. For each AE, the elution profiles generated on the basis of absorbance at 280 nm do not conform to ELISA data for functional activity characteristic of BPs. Moreover, high functional activity was detected in chromatographic fractions that had significantly different molecular weights and no absorbance at 280 nm, which suggests a non-protein (carbohydrate) nature of BPanti-TPO and BPanti-Tg. The semi-preparative size exclusion chromatography of AEanti-TPO and AEanti-Tg with detection by refractometer gave 5,000-7,000 Da fractions containing substances that interact selectively with either anti TPO (BPanti-TPO) or anti-Tg (BPanti-Tg) according to ELISA data. Analysis by two-dimensional NMR spectroscopy including a 1H, 13C-heteronuclear single-quantum coherence experiment indicated that both substances are linear α-1,6-glucans. For the first time, an immunological similarity (molecular mimicry) of glycopolymers of B. bifidum BIM B-733D and human thyroid proteins, TPO and Tg, was shown. On the whole, our data point to a possible role of bifidobacteria in the pathogenesis of autoimmune thyroid diseases (ATD). The main requirements for triggering/acceleration or prevention/abrogation of ATD by bifidobacteria through molecular mimicry mechanism are hypothesised to be (1) genetic predisposition to ATD and (2) intestinal epithelium penetration by α-1,6-glucan.

journal_name

Benef Microbes

journal_title

Beneficial microbes

authors

Kiseleva EP,Mikhailopulo KI,Novik GI,Szwajcer Dey E,Zdorovenko EL,Shashkov AS,Knirel YA

doi

10.3920/BM2013.0015

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

375-91

issue

4

eissn

1876-2883

issn

1876-2891

pii

616315M86K7P2136

journal_volume

4

pub_type

杂志文章
  • Bacteriocins of Gram-positive bacteria having activity spectra extending beyond closely-related species.

    abstract::Bacteriocins are bacterially-produced antimicrobial peptides that have killing activity principally against other relatively closely-related bacteria. Some bacteriocins of the lactic acid bacteria (LAB) have for many years been extensively applied in food biopreservation. However, especially during the last decade, a ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审

    doi:10.3920/BM2018.0126

    authors: Todorov SD,de Melo Franco BDG,Tagg JR

    更新日期:2019-04-19 00:00:00

  • Influence of Lactobacillus brevis 15 and Lactobacillus plantarum 13 on blood glucose and body weight in rats after high-fructose diet.

    abstract::In recent years, many authors have investigated the possible antidiabetic effect of lactic acid bacteria. Lactobacillus species constitute a major part of the lactic acid bacteria group and have been found to exhibit beneficial effects on the development of diabetes and its complications. In the current study, we inve...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2014.0012

    authors: Yakovlieva M,Tacheva T,Mihaylova S,Tropcheva R,Trifonova K,Toleкova A,Danova S,Vlaykova T

    更新日期:2015-01-01 00:00:00

  • Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults.

    abstract::The gut microbiota contributes to host energy metabolism, and altered gut microbiota has been associated with obesity-related metabolic disorders. We previously reported that a probiotic alone or together with a prebiotic controls body fat mass in healthy overweight or obese individuals in a randomised, double-blind, ...

    journal_title:Beneficial microbes

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3920/BM2018.0028

    authors: Hibberd AA,Yde CC,Ziegler ML,Honoré AH,Saarinen MT,Lahtinen S,Stahl B,Jensen HM,Stenman LK

    更新日期:2019-03-13 00:00:00

  • Genes involved in protein metabolism of the probiotic lactic acid bacterium Lactobacillus delbrueckii UFV H2b20.

    abstract::A basic requirement for the prediction of the potential use of lactic acid bacteria (LAB) in the dairy industry is the identification of specific genes involved in flavour-forming pathways. The probiotic Lactobacillus delbrueckii UFV H2b20 was submitted to a genetic characterisation and phylogenetic analysis of genes ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2011.0025

    authors: Do Carmo AP,da Silva DF,De Oliveira MN,Borges AC,De Carvalho AF,De Moraes CA

    更新日期:2011-09-01 00:00:00

  • On the importance of intraindividual variation in nutritional research.

    abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2020.0044

    authors: Larsen OFA,Claassen E,Brummer RJ

    更新日期:2020-10-12 00:00:00

  • Bifidobacterium breve prevents necrotising enterocolitis by suppressing inflammatory responses in a preterm rat model.

    abstract::Necrotising enterocolitis (NEC) is associated with inflammatory responses and barrier dysfunction in the gut. In this study, we investigated the effect of Bifidobacterium breve M-16V on factors related to NEC development using an experimental rat model. Caesarean-sectioned rats were given formula milk with or without ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2015.0035

    authors: Satoh T,Izumi H,Iwabuchi N,Odamaki T,Namba K,Abe F,Xiao JZ

    更新日期:2016-02-01 00:00:00

  • Strategies for the evaluation and selection of potential vaginal probiotics from human sources: an exemplary study.

    abstract::During the last years, the application of probiotics in gynaecological clinical practice has gained increasing relevance regarding therapy and prevention. This trend has also provoked the need for having tailored pharmaceutical preparations containing powerful microbial strains with defined properties. For the develop...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2013.0069

    authors: Domig KJ,Kiss H,Petricevic L,Viernstein H,Unger F,Kneifel W

    更新日期:2014-09-01 00:00:00

  • Effect of Saccharomyces cerevisiae strain UFMG A-905 in experimental model of inflammatory bowel disease.

    abstract::In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-9...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2015.0018

    authors: Tiago FC,Porto BA,Ribeiro NS,Moreira LM,Arantes RM,Vieira AT,Teixeira MM,Generoso SV,Nascimento VN,Martins FS,Nicoli JR

    更新日期:2015-01-01 00:00:00

  • Gut bacterial composition in a mouse model of Parkinson's disease.

    abstract::The mechanism of neurodegeneration in Parkinson's disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to the neurodegenerative processes. In PD patients as well as in animal models for PD, alpha-synuclein-positive enteric neurons in the col...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2017.0202

    authors: Perez-Pardo P,Dodiya HB,Engen PA,Naqib A,Forsyth CB,Green SJ,Garssen J,Keshavarzian A,Kraneveld AD

    更新日期:2018-09-18 00:00:00

  • Screening for lactic acid bacteria capable of inhibiting Campylobacter jejuni in in vitro simulations of the broiler chicken caecal environment.

    abstract::Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim o...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2012.0021

    authors: Robyn J,Rasschaert G,Messens W,Pasmans F,Heyndrickx M

    更新日期:2012-12-01 00:00:00

  • Persistent infection by Salmonella enterica servovar Typhimurium: are synbiotics a therapeutic option? - a case report.

    abstract::Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Despite the recommendation not to use ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2018.0080

    authors: Piatek J,Sommermeyer H,Bernatek M,Ciechelska-Rybarczyk A,Oleskow B,Mikkelsen LS,Barken KB

    更新日期:2019-03-13 00:00:00

  • In vitro evaluation of Bifidobacterium strains of human origin for potential use in probiotic functional foods.

    abstract::The present study investigated some in vitro properties for probiotic use of four strains of bifidobacteria isolated from faeces of healthy children (Bifidobacterium longum 51A, Bifidobacterium breve 1101A, Bifidobacterium pseudolongum 1191A and Bifidobacterium bifidum 1622A). In vitro tests were carried out to compar...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2012.0052

    authors: Souza TC,Silva AM,Drews JR,Gomes DA,Vinderola CG,Nicoli JR

    更新日期:2013-06-01 00:00:00

  • Probiotic properties of native Lactobacillus spp. strains for dairy calves.

    abstract::The use of native microorganisms with probiotic capacity is an alternative tool for the treatment and prevention of several diseases that affect animals, such as neonatal calf diarrhoea. The selection of probiotic strains within a collection is based on different in vitro and in vivo assays, which predict their potent...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2017.0131

    authors: Fernández S,Fraga M,Silveyra E,Trombert AN,Rabaza A,Pla M,Zunino P

    更新日期:2018-06-15 00:00:00

  • Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 assimilate cholesterol and modulate ABCA1, CD36, NPC1L1 and SCARB1 in vitro.

    abstract::There is growing interest in the use of probiotic lactic acid bacteria (LAB) for prevention of hypercholesterolaemia. This study assessed the cholesterol lowering ability of Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in growth media. Both LAB yielded >98% (39.2 μg/ml) cholesterol lowering in growt...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2016.0048

    authors: Lim FT,Lim SM,Ramasamy K

    更新日期:2017-02-07 00:00:00

  • Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome.

    abstract::The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut mi...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审

    doi:10.3920/BM2013.0033

    authors: König J,Brummer RJ

    更新日期:2014-09-01 00:00:00

  • Growth advantage of Streptococcus thermophilus over Lactobacillus bulgaricus in vitro and in the gastrointestinal tract of gnotobiotic rats.

    abstract::The yoghurt bacteria, Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus, are alleged to have beneficial effects on human health. The objective of this study was to characterise growth, biochemical activity and competitive behaviour of these two bacteria in vitro and in vivo. S. thermophilus LMD-...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2012.0012

    authors: Ben-Yahia L,Mayeur C,Rul F,Thomas M

    更新日期:2012-09-01 00:00:00

  • Are probiotic treatments useful on fibromyalgia syndrome or chronic fatigue syndrome patients? A systematic review.

    abstract::Evidence suggests that the gut microbiota might play an important role in fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). Our goal is to systematically review the reported effect of probiotic treatments in patients diagnosed with FMS or CFS. A systematic review was carried out using 14 databases (PubMe...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2017.0125

    authors: Roman P,Carrillo-Trabalón F,Sánchez-Labraca N,Cañadas F,Estévez AF,Cardona D

    更新日期:2018-06-15 00:00:00

  • Phytate-degrading Pediococcus pentosaceus CFR R123 for application in functional foods.

    abstract::The present work looks at the role of phytate-degrading Pediococcus pentosaceus CFR R123 application in functional foods to evaluate the fate of phytate and calcium solubility during fermentation. Under standard conditions, CFR R123 grown in modified MRS containing sodium phytate CFR R123 showed 43% degradation of sod...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2010.0031

    authors: Raghavendra P,Ushakumari SR,Halami PM

    更新日期:2011-03-01 00:00:00

  • Prebiotics to manage the microbial control of energy homeostasis.

    abstract::The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial ...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审

    doi:10.3920/BM2011.0020

    authors: Grootaert C,Marzorati M,Van den Abbeele P,Van de Wiele T,Possemiers S

    更新日期:2011-12-01 00:00:00

  • Effect of a yoghurt drink containing Lactobacillus strains on bacterial vaginosis in women - a double-blind, randomised, controlled clinical pilot trial.

    abstract::Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been is...

    journal_title:Beneficial microbes

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3920/BM2017.0018

    authors: Laue C,Papazova E,Liesegang A,Pannenbeckers A,Arendarski P,Linnerth B,Domig KJ,Kneifel W,Petricevic L,Schrezenmeir J

    更新日期:2018-01-29 00:00:00

  • Intestinal microbiota and oral administration of Enterococcus faecium associated with the growth performance of new-born piglets.

    abstract::The oral administration of Enterococcus faecium EF1 to new-born suckling and weaning piglets along with their growth performances and intestinal microbiota was investigated in this study. Twenty-four new-born piglets were initially divided into 2 groups. The probiotics group received 2 ml of 10% sterilised skimmed mil...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,随机对照试验

    doi:10.3920/BM2015.0099

    authors: Wang YB,Du W,Fu AK,Zhang XP,Huang Y,Lee KH,Yu K,Li WF,Li YL

    更新日期:2016-09-01 00:00:00

  • Is it who you are or what you do that is important in the human gut?

    abstract::The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defin...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2013.0016

    authors: Avershina E,Rudi K

    更新日期:2013-09-01 00:00:00

  • Lactobacillus-produced exopolysaccharides and their potential health benefits: a review.

    abstract::Lactic acid bacteria, such as those of the Lactobacillus genus, naturally reside within the microbiota of the human body and have long been used as starter cultures and probiotic enhancers in fermented foods, such as fermented drinks, yoghurts and cheeses. Many of the beneficial qualities of these bacteria have tradit...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,评审

    doi:10.3920/BM2014.0117

    authors: Patten DA,Laws AP

    更新日期:2015-01-01 00:00:00

  • Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation.

    abstract::Dysbiosis may contribute to constipation and its symptoms, therefore probiotic administration could improve significantly gut health and functions. The aim of the study was to investigate the effects of a long-lasting administration of Lactobacillus reuteri DSM 17938 (LR DSM 17938) on symptoms and quality of life (QoL...

    journal_title:Beneficial microbes

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3920/BM2017.0049

    authors: Riezzo G,Orlando A,D'Attoma B,Linsalata M,Martulli M,Russo F

    更新日期:2018-01-29 00:00:00

  • Identification and characterisation of lactobacilli isolated from Kimere, a spontaneously fermented pearl millet dough from Mbeere, Kenya (East Africa).

    abstract::The objective of the study was to isolate potential probiotic lactobacilli from Kimere, a pearl millet dough prepared in the Mbeere community of Kenya, East Africa, by fermentation for 18-24 hours. Kimere samples, collected from 11 different homesteads in Mbeere, showed average pH values of 3.63±0.29. Counts of presum...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2010.0019

    authors: Njeru PN,Rösch N,Ghadimi D,Geis A,Bockelmann W,de Vrese M,Schrezenmeir J,Heller KJ

    更新日期:2010-09-01 00:00:00

  • Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions.

    abstract::Obesity is highly correlated with the dysbiosis of intestinal microbiota, and bifidobacteria are one of the soft targets of this metabolic syndrome. The aim of this study is to evaluate the efficacy of Bifidobacterium sp. MKK4 and rice-based fermented foods on physical, haematological, gut microbiota and lypogenic-lyp...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2017.0056

    authors: Ray M,Hor PK,Ojha D,Soren JP,Singh SN,Mondal KC

    更新日期:2018-04-25 00:00:00

  • The use of konjac glucomannan hydrolysates to recover healthy microbiota in infected vaginas treated with an antifungal agent.

    abstract::The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assi...

    journal_title:Beneficial microbes

    pub_type: 杂志文章,随机对照试验

    doi:10.3920/BM2011.0021

    authors: Tester R,Al-Ghazzewi F,Shen N,Chen Z,Chen F,Yang J,Zhang D,Tang M

    更新日期:2012-03-01 00:00:00

  • The effects of the Lactobacillus casei strain on obesity in children: a pilot study.

    abstract::There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and orga...

    journal_title:Beneficial microbes

    pub_type: 临床试验,杂志文章

    doi:10.3920/BM2016.0170

    authors: Nagata S,Chiba Y,Wang C,Yamashiro Y

    更新日期:2017-08-24 00:00:00

  • The serotonin receptor mediates changes in autonomic neurotransmission and gastrointestinal transit induced by heat-killed Lactobacillus brevis SBC8803.

    abstract::Lactobacilli exhibit several health benefits in mammals, including humans. Our previous reports established that heat-killed Lactobacillus brevis SBC8803 (SBC8803) increased both efferent gastric vagal nerve activity and afferent intestinal vagal nerve activity in rats. We speculated that this strain could be useful f...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2015.0031

    authors: Horii Y,Nakakita Y,Misonou Y,Nakamura T,Nagai K

    更新日期:2015-01-01 00:00:00

  • Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis.

    abstract::Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spina...

    journal_title:Beneficial microbes

    pub_type: 杂志文章

    doi:10.3920/BM2015.0159

    authors: Stanisavljević S,Lukić J,Momčilović M,Miljković M,Jevtić B,Kojić M,Golić N,Mostarica Stojković M,Miljković D

    更新日期:2016-06-01 00:00:00