Abstract:
:The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defining operational taxonomic units (OTUs), which are binned groups of bacteria based on sequence homology. Furthermore, the current metagenomic approaches where the total DNA in a sample is mixed prior to sequencing and subsequently resolved by a bioinformatics approach, are highly error prone with respect to both functional and phylotype assignments. We argue that the directions of the OTU and metagenome errors are such that stable phylotypes are overlooked, while functional stability is overestimated. Taking these errors into account, we propose that phylotype represents an interface for functionality, and is for this reason an important determinant for the services provided by the gut microbiota to the host.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Avershina E,Rudi Kdoi
10.3920/BM2013.0016subject
Has Abstractpub_date
2013-09-01 00:00:00pages
219-22issue
3eissn
1876-2883issn
1876-2891pii
936670137172U013journal_volume
4pub_type
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-12-22 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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