Abstract:
:Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be influenced in order to optimise the statistical power. Our simulations demonstrate that steering the study population towards a low intraindividual variation dramatically improves statistical power. A more than 10-fold decrease of number-to-treat could be reached. Also, a careful balancing between the number of subjects and measurements per subject, in combination with possible stratification of the subjects into responders and non-responders, based on inherent intraindividual variation, improves the likelihood to reach statistically significant results. Our results also show that traditional dogmas, with respect to clinical trials, i.e. aiming at low interindividual variation and a high number (n) of study participants, should be re-evaluated in favour of reducing intraindividual variation. This reduction in intraindividual variation could be achieved by maintaining a steady lifestyle, including dietary habits among others, within the timeframe of the intervention study.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Larsen OFA,Claassen E,Brummer RJdoi
10.3920/BM2020.0044subject
Has Abstractpub_date
2020-10-12 00:00:00pages
511-517issue
6eissn
1876-2883issn
1876-2891journal_volume
11pub_type
杂志文章abstract::Bacteriocins are bacterially-produced antimicrobial peptides that have killing activity principally against other relatively closely-related bacteria. Some bacteriocins of the lactic acid bacteria (LAB) have for many years been extensively applied in food biopreservation. However, especially during the last decade, a ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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更新日期:2019-04-19 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0041
更新日期:2010-11-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2010.0031
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0012
更新日期:2012-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2019-03-13 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2011.0020
更新日期:2011-12-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0012
更新日期:2015-01-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2011.0025
更新日期:2011-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2014.0117
更新日期:2015-01-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2019-12-09 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2020-03-27 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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