Abstract:
:There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children. The obese group underwent diet and exercise therapy for 6 months and then were given an LcS beverage daily for another 6 months and the body weight and serological markers were monitored. Significant reductions in the faecal concentrations of Bifidobacterium (obese group, 7.9±1.5 vs non-obese group, 9.8±0.5 Log10cells/g; P<0.01) along with a significant decline in the Bacteroides fragilis group, Atopobium cluster and Lactobacillus gasseri subgroup, and acetic acid (obese group, 45.1±16.9 vs non-obese group, 57.9±17.6 μmol/g; P<0.05) were observed in the obese group at baseline. A significant decline in body weight (-2.9±4.6%; P<0.05) and an elevation in the high density lipoprotein cholesterol level (+11.1±17.6%; P<0.05) were observed 6 months after ingestion of the LcS beverage compared to baseline. Furthermore, a significant increase in the faecal concentration of Bifidobacterium (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) and an apparent increase in the acetic acid concentration (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) were observed 6 months after ingestion. LcS contributed to weight loss while also improving the lipid metabolism in obese children via a significant increase in the faecal Bifidobacterium numbers and the acetic acid concentration.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Nagata S,Chiba Y,Wang C,Yamashiro Ydoi
10.3920/BM2016.0170subject
Has Abstractpub_date
2017-08-24 00:00:00pages
535-543issue
4eissn
1876-2883issn
1876-2891journal_volume
8pub_type
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Beneficial microbes
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2018-01-29 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0015
更新日期:2013-12-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2019-03-13 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2018-06-15 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Beneficial microbes
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更新日期:2016-06-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2018-01-29 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
pub_type: 杂志文章
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