Abstract:
:Gut bacteria influence host anatomy and physiology. It has been proposed that bacterial metabolites including polyamines are responsible for intestinal maturation and mucosal growth. We have hypothesised that bacterially produced polyamines act as trophic factors and thereby influence large intestinal crypt depth and thickness of the different gut layers. For that purpose, germ-free mice were associated with two different microbial consortia. One group was colonised with a simplified human microbiota (SIHUMI). The second group was associated with SIHUMI + Fusobacterium varium (SIHUMI + Fv), which is known to produce high amounts of polyamines. Polyamine concentrations were measured by HPLC and morphological parameters were determined microscopically. Germ-free and conventional mice served as controls. The caecal putrescine concentration of the SIHUMI + Fv was 61.8 μM (47.6-75.5 μM), whereas that of conventional and SIHUMI mice was 28.8 μM (1.3-41.7 μM) and 24.5 μM (16.8-29.1 μM), respectively. The caecal putrescine concentration of germ-free mice was only 0.6 μM (0-1.0 μM). Caecal crypt depth and thickness of the different caecal layers revealed no significant differences between SIHUMI and SIHUMI + Fv mice. However, the crypt depth in the caeca of conventional, SIHUMI and SIHUMI + Fv mice was increased by 48.6% (P<0.001), 39.7% (P<0.001) and 28.5% (P<0.05), respectively, compared to germ-free mice. These findings indicate that increased intestinal putrescine concentrations do not influence gut morphology in our gnotobiotic adolescent mice.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Slezak K,Hanske L,Loh G,Blaut Mdoi
10.3920/BM2012.0047subject
Has Abstractpub_date
2013-09-01 00:00:00pages
253-66issue
3eissn
1876-2883issn
1876-2891pii
P7607VR80865X2U9journal_volume
4pub_type
杂志文章abstract::The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assi...
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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journal_title:Beneficial microbes
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pub_type: 杂志文章,随机对照试验
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