Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome.

Abstract:

:The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut microbiota. IBS is a multifactorial chronic disorder characterised by various abdominal complaints and a worldwide prevalence of 10-20%. Even though its aetiology and pathophysiology are complex and not well understood, it is widely accepted that aberrations along the microbe-gut-brain axis are involved. In this review, it will be discussed how exogenous factors, e.g. antibiotics, can cause disbalance in the intestinal microbiota and thereby contribute to the development of IBS. In addition, several new IBS treatment options that aim at re-establishing a healthy, beneficial ecosystem will be described. These include antibiotics, probiotics, prebiotics and faecal transplantation.

journal_name

Benef Microbes

journal_title

Beneficial microbes

authors

König J,Brummer RJ

doi

10.3920/BM2013.0033

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

247-61

issue

3

eissn

1876-2883

issn

1876-2891

pii

V4L563K37365L664

journal_volume

5

pub_type

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