Abstract:
:The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assigned randomly into two groups to receive a standard antifungal treatment or a standard antifungal treatment plus pessary capsules containing 200 mg GMH (twice a week for thirty days). Patients were assessed on day zero, sixteen and thirty of the trial. Several parameters were determined including yeast and bacterial counts, the KOH test, pH, Gram staining and wet mount microscopic observations. The results showed that the counts of Candida were diminished completely with antifungal treatment for both groups. However, the total bacterial counts increased with time in the GMH pessary group unlike the control. The normalised average KOH scores were reduced sharply with time in both groups although in the control group scores started to increase after sixteen days. The normalised average white blood cell scores also decreased with time for both groups. Epithelial cell scores decreased only for the GMH pessary group while clue cells and yeast-like fungi decreased with time for both control and GMH pessary groups. These results indicate the improvement of vaginal health recovery (post antifungal treatment for Candida infection) and especially the presence of healthy microflora due to the introduction of GMH in the vagina. The data indicate that it would be worth examining further the health benefits of GMH in a vaginal health format with a view to employing the material as a prophylactic or therapeutic agent. It provides an alternative approach to reducing vaginal infections and promoting consumer health.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Tester R,Al-Ghazzewi F,Shen N,Chen Z,Chen F,Yang J,Zhang D,Tang Mdoi
10.3920/BM2011.0021subject
Has Abstractpub_date
2012-03-01 00:00:00pages
61-6issue
1eissn
1876-2883issn
1876-2891pii
V381761172326742journal_volume
3pub_type
杂志文章,随机对照试验abstract::The objective of the study was to isolate potential probiotic lactobacilli from Kimere, a pearl millet dough prepared in the Mbeere community of Kenya, East Africa, by fermentation for 18-24 hours. Kimere samples, collected from 11 different homesteads in Mbeere, showed average pH values of 3.63±0.29. Counts of presum...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2010.0019
更新日期:2010-09-01 00:00:00
abstract::Lactobacilli exhibit several health benefits in mammals, including humans. Our previous reports established that heat-killed Lactobacillus brevis SBC8803 (SBC8803) increased both efferent gastric vagal nerve activity and afferent intestinal vagal nerve activity in rats. We speculated that this strain could be useful f...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0031
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abstract::Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of a patient with the aim to restore a disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on faecal microbial composition, its functional capacity, faecal metabolite profiles and th...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0010
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abstract::Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0031
更新日期:2014-06-01 00:00:00
abstract::Ingestion of milks fermented by Lactobacillus strains showing probiotic properties is an important tool to maintain gastrointestinal health. In this study, Lactobacillus rhamnosus D1 and Lactobacillus plantarum B7, isolated from Brazilian artisanal cheese, were used as starters for the functional fermented milks to as...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0163
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abstract::Over the past decade it has become clear that probiotic and commensal interactions with mucosal dendritic cells in the lamina propria or epithelial cells lining the mucosa can modulate specific functions of the mucosal immune system. Innate pattern-recognition receptors such as TLRs, NLRs and CLRs play a crucial role ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0029
更新日期:2010-11-01 00:00:00
abstract::The mechanism of neurodegeneration in Parkinson's disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to the neurodegenerative processes. In PD patients as well as in animal models for PD, alpha-synuclein-positive enteric neurons in the col...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0202
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abstract::Obesity is highly correlated with the dysbiosis of intestinal microbiota, and bifidobacteria are one of the soft targets of this metabolic syndrome. The aim of this study is to evaluate the efficacy of Bifidobacterium sp. MKK4 and rice-based fermented foods on physical, haematological, gut microbiota and lypogenic-lyp...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0056
更新日期:2018-04-25 00:00:00
abstract::The metabolic end products of the large bowel microbiota contribute significantly to human health. After weaning to solid foods, some of the most important of these are the short chain fatty acids (SCFA) produced by the fermentation of undigested dietary components and endogenous secretions. The main SCFA are acetate,...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0041
更新日期:2010-11-01 00:00:00
abstract::There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and orga...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2016.0170
更新日期:2017-08-24 00:00:00
abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0044
更新日期:2020-10-12 00:00:00
abstract::The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut mi...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2013.0033
更新日期:2014-09-01 00:00:00
abstract::In concern to the continuously rising global prevalence of obesity, diabetes and associated diseases, novel preventive and therapeutic approaches are urgently required. However, to explore and develop such innovative strategies, a meticulous comprehension of the biological basis of these diseases is extremely importan...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/bm2015.0062
更新日期:2016-01-01 00:00:00
abstract::Bifidobacterium bifidum 791 (commercially available as B. bifidum BIM B-733D) cell-surface biopolymers (BPs) interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti TPO and anti Tg, respectively). BPanti-TPO and BPanti-Tg were isolated from the soluble fraction of B. ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0015
更新日期:2013-12-01 00:00:00
abstract::Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been is...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2017.0018
更新日期:2018-01-29 00:00:00
abstract::The past definitions of probiotics and prebiotics have been reviewed and updated recently. According to these concepts, probiotics comprise live microorganisms that confer a health benefit on the host when administered in adequate amounts, whereas a prebiotic is a substrate that is selectively utilised by host microor...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0015
更新日期:2019-10-14 00:00:00
abstract::Alterations of the gut microbiota and mucosal barrier are linked with metabolic diseases. Our aim was to investigate the potential benefit of the potential probiotic Bifidobacterium animalis ssp. lactis 420 in reducing high-fat diet-induced body weight gain and diabetes in mice. In the obesity model, C57Bl/6J mice wer...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0014
更新日期:2014-12-01 00:00:00
abstract::The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2011.0020
更新日期:2011-12-01 00:00:00
abstract::This study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bi...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0098
更新日期:2020-02-19 00:00:00
abstract::The present study investigated some in vitro properties for probiotic use of four strains of bifidobacteria isolated from faeces of healthy children (Bifidobacterium longum 51A, Bifidobacterium breve 1101A, Bifidobacterium pseudolongum 1191A and Bifidobacterium bifidum 1622A). In vitro tests were carried out to compar...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0052
更新日期:2013-06-01 00:00:00
abstract::Vaccination is one of the most important prevention tools providing protection against infectious diseases especially in children below the age of five. According to estimates, more than 5 million lives are saved annually by the implementation of six standard vaccines, including diphtheria, hepatitis B, Haemophilus in...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2019.0121
更新日期:2020-05-11 00:00:00
abstract::The gut microbiota plays a crucial role in gastrointestinal health. Current use of probiotics is aimed at modulating the bacterial gut composition to alleviate specific diseases. The safety and tolerance of three probiotic strains (Bifidobacterium longum subsp. infantis R0033, Lactobacillus helveticus R0052 and Bifido...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2017.0132
更新日期:2018-06-15 00:00:00
abstract::Evidence suggests that the gut microbiota might play an important role in fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). Our goal is to systematically review the reported effect of probiotic treatments in patients diagnosed with FMS or CFS. A systematic review was carried out using 14 databases (PubMe...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0125
更新日期:2018-06-15 00:00:00
abstract::There are numerorus published and ongoing experimental/clinical studies about probiotics and prebiotics, intestinal microbiota and nutrition. Three years ago, at the first International Symposium of Probiotics Prebiotics in Paediatrics in Istanbul (2012) we highlighted the 'paediatric perspective' on these issues and ...
journal_title:Beneficial microbes
pub_type:
doi:10.3920/BM2014.x002
更新日期:2015-01-01 00:00:00
abstract::During the last years, the application of probiotics in gynaecological clinical practice has gained increasing relevance regarding therapy and prevention. This trend has also provoked the need for having tailored pharmaceutical preparations containing powerful microbial strains with defined properties. For the develop...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0069
更新日期:2014-09-01 00:00:00
abstract::The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defin...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0016
更新日期:2013-09-01 00:00:00
abstract::Few studies have examined the effects of smoking habit, the frequency of alcohol drinking, exercise, and fermented milk consumption on defecatory symptoms and gut microbiota composition, and particularly their interactive effects. We examined the effect of these lifestyle factors on bowel movements and gut microbiota ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0057
更新日期:2019-12-09 00:00:00
abstract::Necrotising enterocolitis (NEC) is associated with inflammatory responses and barrier dysfunction in the gut. In this study, we investigated the effect of Bifidobacterium breve M-16V on factors related to NEC development using an experimental rat model. Caesarean-sectioned rats were given formula milk with or without ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0035
更新日期:2016-02-01 00:00:00
abstract::Vaginal lactobacilli offer protection against microbiota imbalance and genitourinary tract infections. We compared vaginal lactobacilli in 50 Estonian women of child-bearing age applying culture-based methods, quantitative PCR and next-generation sequencing (NGS). The culture-based methods found three different lactob...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0154
更新日期:2015-01-01 00:00:00
abstract::The probiotic strain Bifidobacterium bifidum YIT 10347 has been demonstrated to inhibit Helicobacter pylori activity, prevent injury to the gastric mucosa, and improve general gastric malaise symptoms in H. pylori positive patients. This study aimed to investigate the adhering activity and localisation of B. bifidum Y...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0138
更新日期:2016-06-01 00:00:00