Abstract:
:Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Despite the recommendation not to use antibiotics for the treatment of uncomplicated NTS-Salmonella infection, little treatment guidance is available. Clinical findings from a NTS-patient indicate that administration of synbiotics (probiotic bacteria plus prebiotic) might be considered as a treatment option. We report data of a patient who was treated with a synbiotic preparation containing nine different probiotic bacteria and the prebiotic fructooligosaccharides (FOS). Starting from day one of the treatment, the patient experienced an improvement of symptoms and was symptom-free at the end of a 10 days treatment course. After finishing the treatment, the stool proved to be Salmonella enterica serovar Typhimurium negative. In vitro pathogenic inhibition studies showed the inhibitory effects of the multistrain synbiotic mixture against S. Typhimurium. Growth of S. Typhimurium was also inhibited by individual bacterial strains making part of the composition of the mixture. However, he inhibitory effects of individual strains varied significantly, with those of Streptococcus thermophilus St-21 and Lactobacillus helveticus SP-27 exhibiting the strongest inhibitory effect. Persistent infections by S. Typhimurium are a severe concern for the affected patients. Besides the symptomatic burden, infected persons are banned from work in certain areas (e.g. food related service). In addition, patients with persistent S. Typhimurium infections are a threat for the public health in general, as they serve as a reservoir for NTS transmission. The findings indicate that treatment with a synbiotic preparation might provide a treatment option for persistent S. Typhimurium infections. More clinical data have to be gathered to confirm the relevance of this potential treatment approach.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Piatek J,Sommermeyer H,Bernatek M,Ciechelska-Rybarczyk A,Oleskow B,Mikkelsen LS,Barken KBdoi
10.3920/BM2018.0080subject
Has Abstractpub_date
2019-03-13 00:00:00pages
211-217issue
2eissn
1876-2883issn
1876-2891journal_volume
10pub_type
杂志文章abstract::We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep rhythms in mice. The present study evaluated the effect of consumption of heat-killed SBC8803 on sleep architecture in humans. A non-randomised, placebo-controlled, double blind, and crossover pilot study was conducted using vol...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2015.0118
更新日期:2016-09-01 00:00:00
abstract::The gut microbiota contributes to host energy metabolism, and altered gut microbiota has been associated with obesity-related metabolic disorders. We previously reported that a probiotic alone or together with a prebiotic controls body fat mass in healthy overweight or obese individuals in a randomised, double-blind, ...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2018.0028
更新日期:2019-03-13 00:00:00
abstract::The use of native microorganisms with probiotic capacity is an alternative tool for the treatment and prevention of several diseases that affect animals, such as neonatal calf diarrhoea. The selection of probiotic strains within a collection is based on different in vitro and in vivo assays, which predict their potent...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0131
更新日期:2018-06-15 00:00:00
abstract::The probiotic strain Bifidobacterium bifidum YIT 10347 has been demonstrated to inhibit Helicobacter pylori activity, prevent injury to the gastric mucosa, and improve general gastric malaise symptoms in H. pylori positive patients. This study aimed to investigate the adhering activity and localisation of B. bifidum Y...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0138
更新日期:2016-06-01 00:00:00
abstract::Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0031
更新日期:2014-06-01 00:00:00
abstract::This study aimed to systematically evaluate safety of probiotics and synbiotics in immune compromised adults (≥18 years). Safety was analysed using the Common Terminology Clinical Adverse Events (CTCAE version 4.0) classification, thereby providing an update on previous reports using the most recent available clinical...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0079
更新日期:2015-03-01 00:00:00
abstract::Evidence suggests that the gut microbiota might play an important role in fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). Our goal is to systematically review the reported effect of probiotic treatments in patients diagnosed with FMS or CFS. A systematic review was carried out using 14 databases (PubMe...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0125
更新日期:2018-06-15 00:00:00
abstract::The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defin...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0016
更新日期:2013-09-01 00:00:00
abstract::The establishment of the gut microbiota immediately after birth is a dynamic process that may impact lifelong health. At this important developmental stage in early life, human milk oligosaccharides (HMOs) serve as specific substrates to shape the gut microbiota of the nursling. The well-orchestrated transition is imp...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0005
更新日期:2020-11-16 00:00:00
abstract::The metabolic end products of the large bowel microbiota contribute significantly to human health. After weaning to solid foods, some of the most important of these are the short chain fatty acids (SCFA) produced by the fermentation of undigested dietary components and endogenous secretions. The main SCFA are acetate,...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0041
更新日期:2010-11-01 00:00:00
abstract::The past definitions of probiotics and prebiotics have been reviewed and updated recently. According to these concepts, probiotics comprise live microorganisms that confer a health benefit on the host when administered in adequate amounts, whereas a prebiotic is a substrate that is selectively utilised by host microor...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0015
更新日期:2019-10-14 00:00:00
abstract::Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of a patient with the aim to restore a disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on faecal microbial composition, its functional capacity, faecal metabolite profiles and th...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0010
更新日期:2020-12-22 00:00:00
abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0044
更新日期:2020-10-12 00:00:00
abstract::Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been is...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2017.0018
更新日期:2018-01-29 00:00:00
abstract::Alterations of the gut microbiota and mucosal barrier are linked with metabolic diseases. Our aim was to investigate the potential benefit of the potential probiotic Bifidobacterium animalis ssp. lactis 420 in reducing high-fat diet-induced body weight gain and diabetes in mice. In the obesity model, C57Bl/6J mice wer...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0014
更新日期:2014-12-01 00:00:00
abstract::Bifidobacterium bifidum 791 (commercially available as B. bifidum BIM B-733D) cell-surface biopolymers (BPs) interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti TPO and anti Tg, respectively). BPanti-TPO and BPanti-Tg were isolated from the soluble fraction of B. ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0015
更新日期:2013-12-01 00:00:00
abstract::The human body is exposed to many xenobiotic, potentially harmful compounds. The intestinal immune system is crucial in protecting the human body from these substances. Moreover, many microorganisms, residing in the gastrointestinal tract, play an important role in modulating immune responses. Pre- and probiotics may ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2018.0066
更新日期:2019-04-19 00:00:00
abstract::There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and orga...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2016.0170
更新日期:2017-08-24 00:00:00
abstract::The oral administration of Enterococcus faecium EF1 to new-born suckling and weaning piglets along with their growth performances and intestinal microbiota was investigated in this study. Twenty-four new-born piglets were initially divided into 2 groups. The probiotics group received 2 ml of 10% sterilised skimmed mil...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2015.0099
更新日期:2016-09-01 00:00:00
abstract::Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in a series of established in vitro tests. Moreover, incorporation of L. paracasei K5 as starter culture offered organoleptic and technological advantages to novel f...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0183
更新日期:2018-12-07 00:00:00
abstract::Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic L...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2016.0207
更新日期:2017-10-13 00:00:00
abstract::Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spina...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0159
更新日期:2016-06-01 00:00:00
abstract::Necrotising enterocolitis (NEC) is associated with inflammatory responses and barrier dysfunction in the gut. In this study, we investigated the effect of Bifidobacterium breve M-16V on factors related to NEC development using an experimental rat model. Caesarean-sectioned rats were given formula milk with or without ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0035
更新日期:2016-02-01 00:00:00
abstract::The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assi...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2011.0021
更新日期:2012-03-01 00:00:00
abstract::In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used: not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-9...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0018
更新日期:2015-01-01 00:00:00
abstract::The present study investigated some in vitro properties for probiotic use of four strains of bifidobacteria isolated from faeces of healthy children (Bifidobacterium longum 51A, Bifidobacterium breve 1101A, Bifidobacterium pseudolongum 1191A and Bifidobacterium bifidum 1622A). In vitro tests were carried out to compar...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0052
更新日期:2013-06-01 00:00:00
abstract::Clinical studies have shown that probiotics positively affect oral health by decreasing gum bleeding and/or reducing salivary counts of certain oral pathogens. Our aim was to investigate the inhibitory effect of six probiotic lactobacilli against opportunistic oral Candida species. Sugar utilisation by both lactobacil...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0054
更新日期:2015-01-01 00:00:00
abstract::The gut intestinal tract harbours a complex microbiota. Disturbances in the microbiota composition have been associated with several immune dysfunctions such as inflammatory diseases. Specific strains of probiotics have shown to beneficially influence the composition and/or metabolic activity of the endogenous microbi...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2013.0014
更新日期:2014-06-01 00:00:00
abstract::This study evaluated the effects of Bifidobacterium longum 51A on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received Bi...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0098
更新日期:2020-02-19 00:00:00
abstract::Over the past decade it has become clear that probiotic and commensal interactions with mucosal dendritic cells in the lamina propria or epithelial cells lining the mucosa can modulate specific functions of the mucosal immune system. Innate pattern-recognition receptors such as TLRs, NLRs and CLRs play a crucial role ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0029
更新日期:2010-11-01 00:00:00