Abstract:
:Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Despite the recommendation not to use antibiotics for the treatment of uncomplicated NTS-Salmonella infection, little treatment guidance is available. Clinical findings from a NTS-patient indicate that administration of synbiotics (probiotic bacteria plus prebiotic) might be considered as a treatment option. We report data of a patient who was treated with a synbiotic preparation containing nine different probiotic bacteria and the prebiotic fructooligosaccharides (FOS). Starting from day one of the treatment, the patient experienced an improvement of symptoms and was symptom-free at the end of a 10 days treatment course. After finishing the treatment, the stool proved to be Salmonella enterica serovar Typhimurium negative. In vitro pathogenic inhibition studies showed the inhibitory effects of the multistrain synbiotic mixture against S. Typhimurium. Growth of S. Typhimurium was also inhibited by individual bacterial strains making part of the composition of the mixture. However, he inhibitory effects of individual strains varied significantly, with those of Streptococcus thermophilus St-21 and Lactobacillus helveticus SP-27 exhibiting the strongest inhibitory effect. Persistent infections by S. Typhimurium are a severe concern for the affected patients. Besides the symptomatic burden, infected persons are banned from work in certain areas (e.g. food related service). In addition, patients with persistent S. Typhimurium infections are a threat for the public health in general, as they serve as a reservoir for NTS transmission. The findings indicate that treatment with a synbiotic preparation might provide a treatment option for persistent S. Typhimurium infections. More clinical data have to be gathered to confirm the relevance of this potential treatment approach.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Piatek J,Sommermeyer H,Bernatek M,Ciechelska-Rybarczyk A,Oleskow B,Mikkelsen LS,Barken KBdoi
10.3920/BM2018.0080subject
Has Abstractpub_date
2019-03-13 00:00:00pages
211-217issue
2eissn
1876-2883issn
1876-2891journal_volume
10pub_type
杂志文章abstract::Lactic acid bacteria, such as those of the Lactobacillus genus, naturally reside within the microbiota of the human body and have long been used as starter cultures and probiotic enhancers in fermented foods, such as fermented drinks, yoghurts and cheeses. Many of the beneficial qualities of these bacteria have tradit...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2014.0117
更新日期:2015-01-01 00:00:00
abstract::The effects of the probiotic, Propionibacterium jensenii 702 (PJ 702), supplementation on egg productivity, egg shell thickness, fatty acid profile of eggs, and body weight in early layer hens were investigated. Twenty eight twenty-week-old starter pullets were evenly divided into a treatment and a control group for a...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2009.0017
更新日期:2010-03-01 00:00:00
abstract::Gut bacteria influence host anatomy and physiology. It has been proposed that bacterial metabolites including polyamines are responsible for intestinal maturation and mucosal growth. We have hypothesised that bacterially produced polyamines act as trophic factors and thereby influence large intestinal crypt depth and ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0047
更新日期:2013-09-01 00:00:00
abstract::There are numerorus published and ongoing experimental/clinical studies about probiotics and prebiotics, intestinal microbiota and nutrition. Three years ago, at the first International Symposium of Probiotics Prebiotics in Paediatrics in Istanbul (2012) we highlighted the 'paediatric perspective' on these issues and ...
journal_title:Beneficial microbes
pub_type:
doi:10.3920/BM2014.x002
更新日期:2015-01-01 00:00:00
abstract::Previously, we demonstrated that Propionibacterium acnes, a human skin commensal bacterium, ferments glycerol into short-chain fatty acids, including propionic acid. Propionic acid suppressed the growth of Staphylococcus aureus USA300, a community-acquired methicillin-resistant bacterium, in vitro and in vivo. In this...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0031
更新日期:2014-06-01 00:00:00
abstract::Knee osteoarthritis (OA) treatment is challenging due to inefficacy and adverse effects of current medications. Probiotic treatment has been shown to promote bone metabolism, reduce pain and inflammatory responses of age-related musculoskeletal disorders, including OA. We aimed to investigate the effect of probiotic L...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2016.0207
更新日期:2017-10-13 00:00:00
abstract::The use of native microorganisms with probiotic capacity is an alternative tool for the treatment and prevention of several diseases that affect animals, such as neonatal calf diarrhoea. The selection of probiotic strains within a collection is based on different in vitro and in vivo assays, which predict their potent...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0131
更新日期:2018-06-15 00:00:00
abstract::We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep rhythms in mice. The present study evaluated the effect of consumption of heat-killed SBC8803 on sleep architecture in humans. A non-randomised, placebo-controlled, double blind, and crossover pilot study was conducted using vol...
journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2015.0118
更新日期:2016-09-01 00:00:00
abstract::The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assi...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2011.0021
更新日期:2012-03-01 00:00:00
abstract::The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2011.0020
更新日期:2011-12-01 00:00:00
abstract::The anaerobic gut bacterium Akkermansia muciniphila is a well-characterised member of the mucosal microbiota and has shown to be a gut symbiont in human. A. muciniphila has been negatively associated with obesity and its associated metabolic disorders in various human cohorts while treatment with A. muciniphila cells ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0096
更新日期:2017-04-26 00:00:00
abstract::The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut mi...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2013.0033
更新日期:2014-09-01 00:00:00
abstract::The yoghurt bacteria, Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus, are alleged to have beneficial effects on human health. The objective of this study was to characterise growth, biochemical activity and competitive behaviour of these two bacteria in vitro and in vivo. S. thermophilus LMD-...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0012
更新日期:2012-09-01 00:00:00
abstract::The gut microbiota plays a crucial role in gastrointestinal health. Current use of probiotics is aimed at modulating the bacterial gut composition to alleviate specific diseases. The safety and tolerance of three probiotic strains (Bifidobacterium longum subsp. infantis R0033, Lactobacillus helveticus R0052 and Bifido...
journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
doi:10.3920/BM2017.0132
更新日期:2018-06-15 00:00:00
abstract::The human body is exposed to many xenobiotic, potentially harmful compounds. The intestinal immune system is crucial in protecting the human body from these substances. Moreover, many microorganisms, residing in the gastrointestinal tract, play an important role in modulating immune responses. Pre- and probiotics may ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2018.0066
更新日期:2019-04-19 00:00:00
abstract::The metabolic end products of the large bowel microbiota contribute significantly to human health. After weaning to solid foods, some of the most important of these are the short chain fatty acids (SCFA) produced by the fermentation of undigested dietary components and endogenous secretions. The main SCFA are acetate,...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0041
更新日期:2010-11-01 00:00:00
abstract::Nutritional intervention studies, like those with pre- and probiotics, are often hampered by low effect sizes, reducing the power to demonstrate potential efficacy. Here, we perform computer simulations of a hypothetical clinical trial using such an intervention in order to elucidate determining factors that can be in...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0044
更新日期:2020-10-12 00:00:00
abstract::The probiotic strain Bifidobacterium bifidum YIT 10347 has been demonstrated to inhibit Helicobacter pylori activity, prevent injury to the gastric mucosa, and improve general gastric malaise symptoms in H. pylori positive patients. This study aimed to investigate the adhering activity and localisation of B. bifidum Y...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2015.0138
更新日期:2016-06-01 00:00:00
abstract::Vaccination is one of the most important prevention tools providing protection against infectious diseases especially in children below the age of five. According to estimates, more than 5 million lives are saved annually by the implementation of six standard vaccines, including diphtheria, hepatitis B, Haemophilus in...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2019.0121
更新日期:2020-05-11 00:00:00
abstract::Over the past decade it has become clear that probiotic and commensal interactions with mucosal dendritic cells in the lamina propria or epithelial cells lining the mucosa can modulate specific functions of the mucosal immune system. Innate pattern-recognition receptors such as TLRs, NLRs and CLRs play a crucial role ...
journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2010.0029
更新日期:2010-11-01 00:00:00
abstract::Vaginal lactobacilli offer protection against microbiota imbalance and genitourinary tract infections. We compared vaginal lactobacilli in 50 Estonian women of child-bearing age applying culture-based methods, quantitative PCR and next-generation sequencing (NGS). The culture-based methods found three different lactob...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0154
更新日期:2015-01-01 00:00:00
abstract::The current leading view is that functionality and not phylotype is the most important determinant for the services provided by the gut microbiota. Here we present an alternative opinion, advocating the importance of phylotype in addition to function. We believe the literature is misled by technical artifacts in defin...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2013.0016
更新日期:2013-09-01 00:00:00
abstract::Invasion of the gut by pathogenic Salmonella leads to production of IL-8 that initiates inflammatory reactions to combat the bacterium. However, its persistent production causes tissue damage and interventions that suppress IL-8 production prevent tissue damage. We hypothesised that probiotics could mediate their bene...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2009.0021
更新日期:2010-06-01 00:00:00
abstract::Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain, isolated recently from feta-type cheese. Its probiotic potential has been demonstrated in a series of established in vitro tests. Moreover, incorporation of L. paracasei K5 as starter culture offered organoleptic and technological advantages to novel f...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0183
更新日期:2018-12-07 00:00:00
abstract::Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of a patient with the aim to restore a disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on faecal microbial composition, its functional capacity, faecal metabolite profiles and th...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2020.0010
更新日期:2020-12-22 00:00:00
abstract::Evidence suggests that the gut microbiota might play an important role in fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). Our goal is to systematically review the reported effect of probiotic treatments in patients diagnosed with FMS or CFS. A systematic review was carried out using 14 databases (PubMe...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0125
更新日期:2018-06-15 00:00:00
abstract::A basic requirement for the prediction of the potential use of lactic acid bacteria (LAB) in the dairy industry is the identification of specific genes involved in flavour-forming pathways. The probiotic Lactobacillus delbrueckii UFV H2b20 was submitted to a genetic characterisation and phylogenetic analysis of genes ...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2011.0025
更新日期:2011-09-01 00:00:00
abstract::The present study investigated some in vitro properties for probiotic use of four strains of bifidobacteria isolated from faeces of healthy children (Bifidobacterium longum 51A, Bifidobacterium breve 1101A, Bifidobacterium pseudolongum 1191A and Bifidobacterium bifidum 1622A). In vitro tests were carried out to compar...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0052
更新日期:2013-06-01 00:00:00
abstract::Many studies have highlighted the immunomodulatory properties of the probiotic strain Lactobacillus casei BL23. Recently, we demonstrated the ability of this strain to modulate the Th2-oriented immune response in a mouse model of cow's milk allergy based on the induction of a Th17-biased immune response. The probiotic...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0174
更新日期:2017-05-30 00:00:00
abstract::In recent years, many authors have investigated the possible antidiabetic effect of lactic acid bacteria. Lactobacillus species constitute a major part of the lactic acid bacteria group and have been found to exhibit beneficial effects on the development of diabetes and its complications. In the current study, we inve...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2014.0012
更新日期:2015-01-01 00:00:00