Abstract:
:Gut microbiota and gut-associated lymphoid tissue have been increasingly appreciated as important players in pathogenesis of various autoimmune diseases, including multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis that can be induced with an injection of spinal cord homogenate emulsified in complete Freund's adjuvant in Dark Agouti (DA) rats, but not in Albino Oxford (AO) rats. In this study, mesenteric lymph nodes (MLN), Peyer's patches (PP) and gut microbiota were analysed in these two rat strains. There was higher proportion of CD4(+) T cells and regulatory T cells in non-immunised DA rats in comparison to AO rats. Also, DA rat MLN and PP cells were higher producers of pro-inflammatory cytokines interferon-γ and interleukin-17. Finally, microbial analyses showed that uncultivated species of Turicibacter and Atopostipes genus were exclusively present in AO rats, in faeces and intestinal tissue, respectively. Thus, it is clear that in comparison of an EAE-susceptible with an EAE-resistant strain of rats, various discrepancies at the level of gut associated lymphoid tissue, as well as at the level of gut microbiota can be observed. Future studies should determine if the differences have functional significance for EAE pathogenesis.
journal_name
Benef Microbesjournal_title
Beneficial microbesauthors
Stanisavljević S,Lukić J,Momčilović M,Miljković M,Jevtić B,Kojić M,Golić N,Mostarica Stojković M,Miljković Ddoi
10.3920/BM2015.0159subject
Has Abstractpub_date
2016-06-01 00:00:00pages
363-73issue
3eissn
1876-2883issn
1876-2891journal_volume
7pub_type
杂志文章abstract::In recent years, many authors have investigated the possible antidiabetic effect of lactic acid bacteria. Lactobacillus species constitute a major part of the lactic acid bacteria group and have been found to exhibit beneficial effects on the development of diabetes and its complications. In the current study, we inve...
journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
pub_type: 杂志文章,随机对照试验
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journal_title:Beneficial microbes
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doi:10.3920/BM2012.0050
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journal_title:Beneficial microbes
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journal_title:Beneficial microbes
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doi:10.3920/BM2013.0016
更新日期:2013-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3920/BM2016.0207
更新日期:2017-10-13 00:00:00
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journal_title:Beneficial microbes
pub_type:
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更新日期:2015-01-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
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更新日期:2020-10-12 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2011.0025
更新日期:2011-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2010.0019
更新日期:2010-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2019-03-13 00:00:00
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
doi:10.3920/BM2015.0118
更新日期:2016-09-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
doi:10.3920/BM2014.0117
更新日期:2015-01-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 临床试验,杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章
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journal_title:Beneficial microbes
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Beneficial microbes
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更新日期:2020-02-19 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0047
更新日期:2013-09-01 00:00:00
abstract::Hypercholesterolemia is a main risk factor of cardiovascular disease. Probiotics are a safe approach to reduce elevated cholesterol without any deleterious effect to human health. Saccharomyces boulardii CNCM I-745 probiotic properties are well documented in a context of intestinal dysbiosis. Recent in vitro and precl...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2018.0134
更新日期:2019-05-28 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0021
更新日期:2012-12-01 00:00:00
abstract::The past definitions of probiotics and prebiotics have been reviewed and updated recently. According to these concepts, probiotics comprise live microorganisms that confer a health benefit on the host when administered in adequate amounts, whereas a prebiotic is a substrate that is selectively utilised by host microor...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0015
更新日期:2019-10-14 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2012.0052
更新日期:2013-06-01 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2017.0056
更新日期:2018-04-25 00:00:00
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journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2016.0048
更新日期:2017-02-07 00:00:00
abstract::Intestinal and human milk microbiota studies during infancy have shown variations according to geographical location, delivery mode, gestational age, and mother-related factors during pregnancy. In this study, we performed metagenomic mycobiota analyses of 44 transient and mature human milk among five different groups...
journal_title:Beneficial microbes
pub_type: 杂志文章
doi:10.3920/BM2019.0158
更新日期:2020-03-27 00:00:00