KCC2 antagonism increases neuronal network excitability but disrupts ictogenesis in vitro.

abstract：:Electrophysiological analysis has revealed much about the broad coding and neural ensemble dynamics that characterize gustatory cortical (GC) taste processing in awake rats and about how these dynamics relate to behavior. With regard to mice, however, data concerning cortical taste coding have largely been restricted ...

journal_title：Journal of neurophysiology

authors： Levitan D,Lin JY,Wachutka J,Mukherjee N,Nelson SB,Katz DB

更新日期：2019-10-01 00:00:00

abstract：:The human visual system is remarkably sensitive to environmental regularities, which can facilitate behavioral performance when sensory events conform to past experience. The point at which prior knowledge is integrated during visual perception is unclear, particularly for incidentally learned associations. One possib...

journal_title：Journal of neurophysiology

authors： Hall MG,Mattingley JB,Dux PE

更新日期：2018-04-01 00:00:00

abstract：:The excitatory and inhibitory conductances driving the light-evoked currents (LECs) of cat and ferret ON- and OFF-center X ganglion cells were examined in sliced and isolated retina preparations using center spot stimulation in tetrodotoxin (TTX)-containing Ringer. ON-center X ganglion cells showed an increase in an e...

journal_title：Journal of neurophysiology

authors： Cohen ED

更新日期：1998-12-01 00:00:00

abstract：:The mechanisms behind the therapeutic effects of electrical stimulation of the brain in epilepsy and other disorders are poorly understood. Previous studies in vitro have shown that uniform electric fields can suppress epileptiform activity through a direct polarizing effect on neuronal membranes. Such an effect depen...

journal_title：Journal of neurophysiology

authors： Mikkelsen R,Andreasen M,Nedergaard S

更新日期：2013-06-01 00:00:00

abstract：:Across the entire human body, postural tone might play its most critical role in the body's axis because the axis joins the four limbs and head into a single functioning unit during complex motor tasks as well as in static postures. Although postural tone is commonly viewed as low-level, tonic motor activity, we hypot...

journal_title：Journal of neurophysiology

authors： Gurfinkel V,Cacciatore TW,Cordo P,Horak F,Nutt J,Skoss R

更新日期：2006-11-01 00:00:00

abstract：:Tetanus toxin reduces monosynaptic inhibitory and excitatory synaptic transmission in mouse spinal cord neurons in culture. Inhibitory transmission is preferentially reduced by the toxin; however, excitatory transmission is also ultimately reduced and blocked by the concentrations of toxin used in these studies. Recor...

journal_title：Journal of neurophysiology

authors： Bergey GK,Bigalke H,Nelson PG

更新日期：1987-01-01 00:00:00

abstract：:Whole cell membrane currents induced by the inflammatory mediators, bradykinin, 5-hydroxytryptamine (5-HT) and prostaglandin E2, were investigated in capsaicin-sensitive dorsal root ganglion (DRG) neurons from newborn rats grown on a monolayer of hippocampal glia without nerve growth factor (NGF). When firmly attached...

journal_title：Journal of neurophysiology

authors： Vyklický L,Knotková-Urbancová H,Vitásková Z,Vlachová V,Kress M,Reeh PW

更新日期：1998-02-01 00:00:00

abstract：:1. The neurophysiological basis for the sensation of prickle evoked by contact of some fabrics with the skin is reported. 2. Single-unit sensory nerve recordings from the rabbit saphenous nerve were used to identify the receptors responsible for fabric-evoked prickle. These recordings showed that all low-threshold mec...

journal_title：Journal of neurophysiology

authors： Garnsworthy RK,Gully RL,Kenins P,Mayfield RJ,Westerman RA

更新日期：1988-04-01 00:00:00

abstract：:To probe the mechanism of visual suppression, we have raised macaques with strabismus by disinserting the medial rectus muscle in each eye at 1 mo of age. Typically, this operation produces a comitant, alternating exotropia with normal acuity in each eye. Here we describe an unusual occurrence: the development of seve...

journal_title：Journal of neurophysiology

authors： Adams DL,Economides JR,Horton JC

更新日期：2015-05-01 00:00:00

abstract：:Microelectrode arrays (MEAs) are appealing tools to probe large neural ensembles and build neural prostheses. Microelectronics microfabrication technologies now allow building high-density MEAs containing several hundreds of microelectrodes. However, several major problems become limiting factors when the size of the ...

journal_title：Journal of neurophysiology

authors： Heim M,Rousseau L,Reculusa S,Urbanova V,Mazzocco C,Joucla S,Bouffier L,Vytras K,Bartlett P,Kuhn A,Yvert B

更新日期：2012-09-01 00:00:00

abstract：:1. The vibratory response to two-tone stimuli was measured in the basilar membrane of the chinchilla cochlea by means of the Mössbauer technique or laser velocimetry. Measurements were made at sites with characteristic frequency (CF, the frequency at which an auditory structure is most sensitive) of 7-10 kHz, located ...

journal_title：Journal of neurophysiology

authors： Ruggero MA,Robles L,Rich NC

更新日期：1992-10-01 00:00:00

abstract：:Microelectrode studies in monkeys performing short-term memory tasks show the sustained elevated discharge of cortical neurons during the retention of recalled sensory information. Cortical cells that are part of memory networks are assumed to receive numerous inputs of excitatory as well as inhibitory nature and loca...

journal_title：Journal of neurophysiology

authors： Bodner M,Zhou YD,Fuster JM

更新日期：1997-04-01 00:00:00

abstract：:1. In four human subjects, we measured the latency of saccadic eye movements made to a second, eccentric target after an initial, foveated target was extinguished. In separate interleaved trails, the targets were either both stationary ("fixation") or both moving with the same velocity ("pursuit"). For both fixation a...

journal_title：Journal of neurophysiology

authors： Krauzlis RJ,Miles FA

更新日期：1996-12-01 00:00:00

abstract：:Synapsin is a synaptic vesicle-associated protein implicated in the regulation of vesicle trafficking and transmitter release, but its role in heterosynaptic plasticity remains elusive. Moreover, contradictory results have obscured the contribution of synapsin to homosynaptic plasticity. We previously reported that th...

journal_title：Journal of neurophysiology

authors： Fioravante D,Liu RY,Netek AK,Cleary LJ,Byrne JH

更新日期：2007-12-01 00:00:00

abstract：:Gain modulation is a ubiquitous phenomenon in cortical neurons, providing flexibility to operate under changing conditions. The prevailing view is that this modulation reflects a change in the relationship between mean input and output firing rate brought about by variation in neuronal membrane characteristics. An alt...

journal_title：Journal of neurophysiology

authors： Azouz R

更新日期：2005-10-01 00:00:00

abstract：:The marine mollusk Clione limacina, when swimming, can stabilize different body orientations in the gravitational field. The stabilization is based on the reflexes initiated by activation of the statocyst receptor cells and mediated by the cerebro-pedal interneurons that produce excitation of the motoneurons of the ef...

journal_title：Journal of neurophysiology

authors： Deliagina TG,Orlovsky GN,Selverston AI,Arshavsky YI

更新日期：2000-01-01 00:00:00

abstract：:The purpose of these studies was to determine the role of gracile nucleus and the effects of l-arginine-derived nitric oxide (NO) synthesis in the nucleus on the cardiovascular responses to electroacupuncture (EA) stimulation of "Zusanli" (ST36). Arterial blood pressure and heart rate were monitored during EA stimulat...

journal_title：Journal of neurophysiology

authors： Chen S,Ma SX

更新日期：2003-08-01 00:00:00

abstract：:Paw-shake responses (PSRs) were evoked by wrapping masking tape around the hind-paw in nine cats spinalized at the T12 level either at 2 or 12 wk of age or as young adults (10-12 mo). Electromyographic responses of ankle extensors (LG and SOL) and one ankle flexor (TA) were recorded through the 6th mo after cord trans...

journal_title：Journal of neurophysiology

authors： Sabin C,Smith JL

更新日期：1984-04-01 00:00:00

abstract：:1. The response to an optimally oriented stimulus of both simple and complex cells in the cat's striate visual cortex (area 17) can be suppressed by the superposition of an orthogonally oriented drifting grating. This effect is referred to as cross-orientation suppression. We have examined the spatial organization and...

journal_title：Journal of neurophysiology

authors： DeAngelis GC,Robson JG,Ohzawa I,Freeman RD

更新日期：1992-07-01 00:00:00

abstract：:The hearing ability of five Japanese macaques (Macaca fuscata) was assessed following two-stage bilateral auditory cortex lesions. The animals were tested using a shock-avoidance procedure with a conditioned-suppression procedure used for comparison in two cases. The animals initially were unable to respond to sound, ...

journal_title：Journal of neurophysiology

authors： Heffner HE,Heffner RS

更新日期：1986-02-01 00:00:00

abstract：:1. There is a long-standing debate about whether the large spiny cells in the hilar region of the hippocampus should be classified as pyramidal cells of Ammon's horn or as a distinct cell type of the dentate gyrus. The rationale for grouping these hilar neurons (termed "mossy cells") with pyramidal cells of Ammon's ho...

journal_title：Journal of neurophysiology

authors： Buckmaster PS,Strowbridge BW,Schwartzkroin PA

更新日期：1993-10-01 00:00:00

abstract：:Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists block...

journal_title：Journal of neurophysiology

authors： Wang P,Slaughter MM

更新日期：2005-06-01 00:00:00

abstract：:The relationship between neck muscle electromyography (EMG) and torsional head rotation (about the nasooccipital axis) is difficult to assess during normal gaze behaviors with the head upright. Here, we induced acute head tilts similar to cervical dystonia (torticollis) in two monkeys by electrically stimulating 20 in...

journal_title：Journal of neurophysiology

authors： Farshadmanesh F,Byrne P,Wang H,Corneil BD,Crawford JD

更新日期：2012-12-01 00:00:00

abstract：:1. Extracellular bath application of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-62 to hippocampal slices in vitro blocked the induction of long-term depression (LTD) by low-frequency Schaffer collateral stimulation (1 Hz/15 min) of the same concentration as has been shown previously to pre...

journal_title：Journal of neurophysiology

authors： Stanton PK,Gage AT

更新日期：1996-09-01 00:00:00

abstract：:Many neurons in the dorsal region of the medial superior temporal area (MSTd) of monkey cerebral cortex respond to optic flow stimuli in which the center of motion is shifted off the center of the visual field. Each shifted-center-of-motion stimulus presents both different directions of planar motion throughout the vi...

journal_title：Journal of neurophysiology

authors： Duffy CJ,Wurtz RH

更新日期：1997-02-01 00:00:00

abstract：:Recording simultaneous activity of a large number of neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the in vivo performance of a recently developed electrophysiological recording system comprising a two-dimensional, multi-shank, high-density silicon probe...

journal_title：Journal of neurophysiology

authors： Fiáth R,Beregszászi P,Horváth D,Wittner L,Aarts AA,Ruther P,Neves HP,Bokor H,Acsády L,Ulbert I

更新日期：2016-11-01 00:00:00

abstract：:Histamine is a known secretagogue in adrenal chromaffin cells. Activation of G-protein linked H(1) receptors stimulates phospholipase C, which generates inositol trisphosphate leading to release of intracellular calcium stores and stimulation of calcium influx through store operated and other channels. This calcium le...

journal_title：Journal of neurophysiology

authors： Currie KP,Fox AP

更新日期：2000-03-01 00:00:00

abstract：:Using whole cell recordings, I analyzed the intrinsic discharge properties for 285 neurons in Rexed's laminae III-V of isolated hamster spinal cord preparations. Neurons were characterized by their responses to step-wise and ramp-hold depolarizing current applied through the recording pipettes. Tonic cells (133/285; 4...

journal_title：Journal of neurophysiology

authors： Schneider SP

更新日期：2003-07-01 00:00:00

abstract：:Certain hand-held tools alter the mapping between hand motion and motion of the tool end point that must be controlled in order to perform a task. For example, when using a pool cue, the motion of the cue tip is reversed relative to the hand. Previous studies have shown that the time required to initiate a reaching mo...

journal_title：Journal of neurophysiology

authors： Baugh LA,Hoe E,Flanagan JR

更新日期：2012-10-01 00:00:00

abstract：:A pair of antagonistic thermoreceptive cells is associated with each of two peg-in-pit sensilla located on the antennal tip of Aedes aegypti. One, the warm cell, responds to rapid warming with a sudden increase in the rate of discharge. The other, a cold cell, responds to rapid cooling with a sudden increase in the di...

journal_title：Journal of neurophysiology

authors： Gingl E,Hinterwirth A,Tichy H

更新日期：2005-07-01 00:00:00