Distinct synaptic loci of Ca2+/calmodulin-dependent protein kinase II necessary for long-term potentiation and depression.

abstract：:The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in the epileptic brain and serves as a mechanism for synchronization of granule cell epileptiform activity. It has been suggested that this pathway also promotes epileptiform activity by inhibiting GABA(A) receptor function through release of ...

journal_title：Journal of neurophysiology

authors： Molnár P,Nadler JV

更新日期：2001-05-01 00:00:00

abstract：:Multimodal sensory integration facilitates the generation of a unified and coherent perception of the environment. It is now well established that unimodal sensory perceptions, such as vision, are improved in multisensory contexts. Whereas multimodal integration is primarily performed by dedicated multisensory brain r...

journal_title：Journal of neurophysiology

authors： McClure JP Jr,Polack PO

更新日期：2019-06-01 00:00:00

abstract：:Lateral protocerebral interneurons (LPIs) in the central olfactory pathway of the freshwater crayfish Procambarus clarkii reside within the lateral protocerebrum and receive direct input from projection neurons of the olfactory midbrain. The LPIs exhibit periodic (0.5 Hz) changes in membrane potential that are imposed...

journal_title：Journal of neurophysiology

authors： Mellon D Jr,Wheeler CJ

更新日期：1999-03-01 00:00:00

abstract：:The contribution of ascending afferents to the control of speech movement was evaluated by applying unanticipated loads to the lower lip during the generation of combined upper lip-lower lip speech gestures. To eliminate potential contamination due to anticipation or adaptation, loads were applied randomly on only 10-...

journal_title：Journal of neurophysiology

authors： Abbs JH,Gracco VL

更新日期：1984-04-01 00:00:00

abstract：:Operant conditioning was used to train cats with their heads immobilized to localize sound by directing their eyes to the location of the sources. The kinematics of those eye movements were studied and compared with eye movements to visual targets at the same locations. The main finding of this study is that eye movem...

journal_title：Journal of neurophysiology

authors： Populin LC,Yin TC

更新日期：1999-08-01 00:00:00

abstract：:Understanding neural responses with natural stimuli has increasingly become an essential part of characterizing neural coding. Neural responses are commonly characterized by a linear-nonlinear (LN) model, in which the output of a linear filter applied to the stimulus is transformed by a static nonlinearity to determin...

journal_title：Journal of neurophysiology

authors： Sharpee TO,Miller KD,Stryker MP

更新日期：2008-05-01 00:00:00

abstract：:A consistent feature of animal locomotion is the capacity to maintain stable movements in changing environments. Here we describe long-term modification of the swing movement of the hind leg in cats in response to repeatedly impeding the movement of the leg. While studying phase transitions in the hind legs, we discov...

journal_title：Journal of neurophysiology

authors： McVea DA,Pearson KG

更新日期：2007-01-01 00:00:00

abstract：:1. Cats were prepared for chronic recordings from the lumbar enlargement of the spinal dorsal horn. At the beginning of each recording session, a tungsten microelectrode was advanced through the dura in a physiologically intact, awake, drug-free animal, until amplitude discrimination provided a single neuron with a re...

journal_title：Journal of neurophysiology

authors： Kishikawa K,Uchida H,Yamamori Y,Collins JG

更新日期：1995-08-01 00:00:00

abstract：:1. GABAergic mechanisms in the midbrain periaqueductal gray (PAG) have been proposed to control the activity of descending antinociceptive systems and defensive behavior. Here, the effect of neuronal disinhibition by gamma-aminobutyric acid (GABAA) receptor blockade at midbrain sites on spinal neuronal responses to no...

journal_title：Journal of neurophysiology

authors： Sandkühler J,Willmann E,Fu QG

更新日期：1991-01-01 00:00:00

abstract：:We show that fast bimanual coordinative feedback responses can be reversed with changes in task goals. Participants moved a flexible virtual object across a finish line with an upward movement of both hands. In one condition, the middle of the object had to be aligned with a spatial goal at the end of the movement. In...

journal_title：Journal of neurophysiology

authors： Diedrichsen J,Gush S

更新日期：2009-01-01 00:00:00

abstract：:1. Study of memory traces in higher animals requires experimental models possessing well-localized and technically accessible memory traces--plasticity responsible for behavioral change, not dependent on control from elsewhere, and open to detailed investigation. Our purpose has been to develop such a model based on t...

journal_title：Journal of neurophysiology

authors： Wolpaw JR,Lee CL

更新日期：1989-03-01 00:00:00

abstract：:1. Many cells in the superior temporal sulcus (STS) of the monkey that represent the foveal region of the visual field discharge during pursuit eye movements. Damage to these areas produces a deficit in the maintenance of pursuit eye movements when the target towards the side of the brain with the lesion. In the prese...

journal_title：Journal of neurophysiology

authors： Komatsu H,Wurtz RH

更新日期：1989-07-01 00:00:00

abstract：:1. Using an optical method for measuring membrane potential, we have been able to monitor action-potential activity simultaneously in 14 neurons of the supraesophageal ganglion of the barnacle. 2. Under favorable conditions, 4-mV synaptic potentials could also be detected optically. ...

journal_title：Journal of neurophysiology

authors： Salzberg BM,Grinvald A,Cohen LB,Davila HV,Ross WN

更新日期：1977-11-01 00:00:00

abstract：:Robust auditory perception plays a pivotal function for processing behaviorally relevant sounds, particularly with distractions from the environment. The neuronal coding enabling this ability, however, is still not well understood. In this study, we recorded single-unit activity from the primary auditory cortex (A1) o...

journal_title：Journal of neurophysiology

authors： Ni R,Bender DA,Shanechi AM,Gamble JR,Barbour DL

更新日期：2017-02-01 00:00:00

abstract：:Nigrostriatal dopamine denervation plays a major role in basal ganglia circuitry disarray and motor abnormalities of Parkinson's disease (PD). Studies in rodent and primate models have revealed that striatal projection neurons, namely, medium spiny neurons (MSNs), increase the firing frequency. However, their activity...

journal_title：Journal of neurophysiology

authors： Singh A,Liang L,Kaneoke Y,Cao X,Papa SM

更新日期：2015-03-01 00:00:00

abstract：:The operculoinsular cortical region has a major role in the representation of noxious stimuli, based on functional imaging observations, clinical lesion studies, and EEG recordings of specifically pain-related laser-evoked potentials (LEPs) in humans. The source of LEPs has not been identified, and several somatic rep...

journal_title：Journal of neurophysiology

authors： Baumgärtner U,Tiede W,Treede RD,Craig AD

更新日期：2006-11-01 00:00:00

abstract：:We have demonstrated that 4-aminopyridine-3-methanol (4-AP-3-MeOH), a 4-aminopyridine derivative, significantly restores axonal conduction in stretched spinal cord white-matter strips and shows no preference in restoring large and small axons. This compound is 10 times more potent when compared with 4-AP and other der...

journal_title：Journal of neurophysiology

authors： Sun W,Smith D,Fu Y,Cheng JX,Bryn S,Borgens R,Shi R

更新日期：2010-01-01 00:00:00

abstract：:This study was prompted by recent evidence for the existence of positive force feedback in feline locomotor control. Our aim was to establish some basic properties of positive force feedback in relation to load compensation, stability, intrinsic muscle properties, and interaction with displacement feedback. In human s...

journal_title：Journal of neurophysiology

authors： Prochazka A,Gillard D,Bennett DJ

更新日期：1997-06-01 00:00:00

abstract：:The horizontal angular vestibuloocular reflex (VOR) evoked by high-frequency, high-acceleration rotations was studied in four squirrel monkeys after unilateral labyrinthectomy. Spontaneous nystagmus was measured at the beginning and end of each testing session. During the period that animals were kept in darkness (4 d...

journal_title：Journal of neurophysiology

authors： Lasker DM,Hullar TE,Minor LB

更新日期：2000-05-01 00:00:00

abstract：:Internally generated, spontaneous activity is ubiquitous in the cortex, yet it does not appear to have a significant negative impact on sensory processing. Various studies have found that stimulus onset reduces the variability of cortical responses, but the characteristics of this suppression remained unexplored. By r...

journal_title：Journal of neurophysiology

authors： White B,Abbott LF,Fiser J

更新日期：2012-11-01 00:00:00

abstract：:Action potential firing rates are generally limited by the refractory period, which depends on the recovery from inactivation of voltage-gated Na channels. In cerebellar Purkinje neurons, the kinetics of Na channels appear specialized for rapid firing. Upon depolarization, an endogenous open-channel blocker rapidly te...

journal_title：Journal of neurophysiology

authors： Afshari FS,Ptak K,Khaliq ZM,Grieco TM,Slater NT,McCrimmon DR,Raman IM

更新日期：2004-11-01 00:00:00

abstract：:Unitary pallido-nigral synaptic currents were measured using optogenetic stimulation, which activated up to three unitary synaptic inputs to each substantia nigra pars reticulata (SNr) cell. Episodic barrages of synaptic conductances were generated based on in vivo firing patterns of globus pallidus pars externa (GPe)...

journal_title：Journal of neurophysiology

authors： Simmons DV,Higgs MH,Lebby S,Wilson CJ

更新日期：2020-02-01 00:00:00

abstract：:The continuous perception of motion-through-depth is critical for both navigation and interacting with objects in a dynamic three-dimensional (3D) world. Here we used 3D tracking to simultaneously assess the perception of motion in all directions, facilitating comparisons of responses to motion-through-depth to fronto...

journal_title：Journal of neurophysiology

authors： Bonnen K,Huk AC,Cormack LK

更新日期：2017-09-01 00:00:00

abstract：:Interneuron precursors transplanted into visual cortex induce network plasticity during their heterochronic maturation. Such plasticity can have a significant impact on the function of the animal and is normally present only during a brief critical period in early postnatal development. Elucidating the synaptic and ph...

journal_title：Journal of neurophysiology

authors： Larimer P,Spatazza J,Stryker MP,Alvarez-Buylla A,Hasenstaub AR

更新日期：2017-07-01 00:00:00

abstract：:The nucleus of the solitary tract (NST) and the parabrachial nuclei (PbN) are the first and second relays in the rodent central taste pathway. A series of electrophysiological experiments revealed that spontaneous and taste-evoked activities of brain stem gustatory neurons are altered by descending input from multiple...

journal_title：Journal of neurophysiology

authors： Li CS,Lu DP,Cho YK

更新日期：2015-06-01 00:00:00

abstract：:1. Spontaneous synaptic activity in networks formed by dissociated neurons from embryonic rat midbrain was analyzed in tight seal whole cell recordings. 2. Application of furosemide (0.5 mM) to the cell and its surrounding area increased the frequency of spontaneous synaptic currents. Incubation of the culture with fu...

journal_title：Journal of neurophysiology

authors： Jarolimek W,Brunner H,Lewen A,Misgeld U

更新日期：1996-06-01 00:00:00

abstract：:1. Evidence from single-unit recordings suggests that neurons in the medial superior temporal visual area (MST) carry directional signals that influence psychophysical judgements of motion direction. We tested this hypothesis by electrically stimulating clusters of directionally selective neurons in MST (the dorsomedi...

journal_title：Journal of neurophysiology

authors： Celebrini S,Newsome WT

更新日期：1995-02-01 00:00:00

abstract：:1. Biventer cervicis (BC) is an anatomically complex muscle that is divided by tendinous inscriptions into five in-series compartments of motor units. We have analyzed the fiber architecture and fiber-type composition of these different compartments using microdissection and histochemical methods. 2. BC narrows as it ...

journal_title：Journal of neurophysiology

authors： Richmond FJ,Armstrong JB

更新日期：1988-07-01 00:00:00

abstract：:1. In chronically prepared, freely moving rats, electrical stimulation was applied to the angular bundle, and responses were recorded extracellularly at a variety of sites in the ipsilateral hippocampal formation. At each recording site the stimulus-response relationship was tested during four different behavioral sta...

journal_title：Journal of neurophysiology

authors： Winson J,Abzug C

更新日期：1978-05-01 00:00:00

abstract：:The lateral hypothalamus (LH) and the central nucleus of the amygdala (CeA) exert an influence on ingestive behavior and are reciprocally connected to gustatory and viscerosensory areas, including the nucleus of the solitary tract (NST) and the parabrachial nuclei (PbN). We investigated the effects of LH and CeA stimu...

journal_title：Journal of neurophysiology

authors： Li CS,Cho YK,Smith DV

更新日期：2005-03-01 00:00:00