Abstract:
:The purpose of these studies was to determine the role of gracile nucleus and the effects of l-arginine-derived nitric oxide (NO) synthesis in the nucleus on the cardiovascular responses to electroacupuncture (EA) stimulation of "Zusanli" (ST36). Arterial blood pressure and heart rate were monitored during EA stimulation of ST36 following microinjections of agents into gracile nucleus. EA ST36 produced depressor and bradycardiac responses in anesthetized Sprague-Dawley rats. The cardiovascular responses to EA ST36 were blocked by bilateral microinjection of lidocaine into gracile nucleus. Microinjection of L-arginine into gracile nucleus facilitated the hypotensive and bradycardiac responses to EA ST36. The cardiovascular responses to EA ST36 were attenuated by bilateral microinjection of neuronal NO synthase (nNOS) antisense oligos into gracile nucleus. Microinjection of nNOS sense oligos into gracile nucleus did not alter the cardiovascular response to EA ST36. The results demonstrate that a blockade of neuronal conduction in the gracile nucleus inhibits the cardiovascular responses to EA ST36. The hypotensive and bradycardiac responses to EA ST36 are modified by influences of L-arginine-derived NO synthesis in the gracile nucleus. We conclude that NO plays an important role in mediating the cardiovascular responses to EA ST36 through gracile nucleus.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Chen S,Ma SXdoi
10.1152/jn.00170.2003subject
Has Abstractpub_date
2003-08-01 00:00:00pages
780-5issue
2eissn
0022-3077issn
1522-1598pii
00170.2003journal_volume
90pub_type
杂志文章abstract::1. In four human subjects, we measured the latency of saccadic eye movements made to a second, eccentric target after an initial, foveated target was extinguished. In separate interleaved trails, the targets were either both stationary ("fixation") or both moving with the same velocity ("pursuit"). For both fixation a...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1152/jn.1996.76.6.4175
更新日期:1996-12-01 00:00:00
abstract::1. Reflex responses were elicited in muscles that act at the ankle by electrical stimulation of low-threshold afferents from the foot in human subjects who were reclining supine. During steady voluntary contractions, stimulus trains (5 pulses at 300 Hz) were delivered at two intensities to the sural nerve (1.2-4.0 tim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.67.5.1375
更新日期:1992-05-01 00:00:00
abstract::Single pulses of transcranial magnetic stimulation (TMS) result in distal and long-lasting oscillations, a finding directly challenging the virtual lesion hypothesis. Previous research supporting this finding has primarily come from stimulation of the motor cortex. We have used single-pulse TMS with simultaneous EEG t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00739.2010
更新日期:2011-10-01 00:00:00
abstract::Spatial and temporal properties of LGN receptive fields were studied by flashing a small bar of light across the field in 28 discrete steps. The flashes at each of the spatial positions were used to produce 28 PST histograms. These histograms were in turn displayed as a plane, with space on the chi axis, time on the p...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.2.213
更新日期:1976-03-01 00:00:00
abstract::The contribution of ascending afferents to the control of speech movement was evaluated by applying unanticipated loads to the lower lip during the generation of combined upper lip-lower lip speech gestures. To eliminate potential contamination due to anticipation or adaptation, loads were applied randomly on only 10-...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.51.4.705
更新日期:1984-04-01 00:00:00
abstract::Clinical and experimental research has demonstrated that the emotional experience of fear and anxiety impairs postural stability in humans. The current study investigated whether changes in fear and anxiety can also modulate spinal stretch reflexes and the gain of afferent inputs to the primary somatosensory cortex. T...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01030.2010
更新日期:2011-12-01 00:00:00
abstract::It is well established that patterns of sensory input can affect neuroplastic changes during early development. The scope and consequences of experience-dependent plasticity in the adult are less well understood. We studied the possibility that repeated exposure to trains of stroboscopic stimuli could induce a sensiti...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00724.2005
更新日期:2005-12-01 00:00:00
abstract::We studied adjustments in digit forces and moments during holding a vertically oriented handle under slow, externally imposed changes in the width of the grasp. Subjects (n = 8) grasped a customized motorized handle with five digits and held it statically in the air. The handle width either increased (expanded) or dec...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00839.2005
更新日期:2006-04-01 00:00:00
abstract::Three nonspiking interneurons are described in this paper that influence the activity of the motor neurons of three muscles of the proximal leg joints of the stick insect. Interneurons were recorded and stained intracellularly by glass microelectrodes; motor neurons were recorded extracellularly with oil-hook electrod...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.6.2964
更新日期:1998-06-01 00:00:00
abstract::1. The shared inputs to cat retinal ganglion cells have been investigated by studying correlations in the maintained firing of neighboring ganglion cells. The firing of one cell was recorded from its axon in the optic tract, while that of a neighboring cell was simultaneously recorded with a second electrode in the re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.49.2.303
更新日期:1983-02-01 00:00:00
abstract::The physiological basis of flexion spasms in individuals after spinal cord injury (SCI) may involve alterations in the properties of spinal neurons in the flexion reflex pathways. We hypothesize that these changes would be manifested as progressive increases in reflex response with repetitive stimulus application (i.e...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00979.2001
更新日期:2003-01-01 00:00:00
abstract::Humans with spinal cord injury (SCI) modulate locomotor output in response to limb load. Understanding the neural control mechanisms responsible for locomotor adaptation could provide a framework for selecting effective interventions. We quantified feedback and feedforward locomotor adaptations to limb load modulation...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00604.2009
更新日期:2010-09-01 00:00:00
abstract::Second-order vestibular neurons (2 degrees VN) were identified in the isolated frog brain by the presence of monosynaptic excitatory postsynaptic potentials (EPSPs) after separate electrical stimulation of individual vestibular nerve branches. Combinations of one macular and the three semicircular canal nerve branches...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00370.2002
更新日期:2002-11-01 00:00:00
abstract::Our continuous perception of the world could be the result of discrete sampling, where individual snapshots are seamlessly fused into a coherent stream. It has been argued that endogenous oscillatory brain activity could provide the functional substrate of cortical rhythmic sampling. A new study demonstrates that cort...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00810.2017
更新日期:2018-04-01 00:00:00
abstract::Using near-infrared spectroscopy (NIRS) and multichannel probes, we studied hemoglobin (Hb) concentration changes when single-pulse transcranial magnetic stimulation (TMS) was applied over the left hemisphere primary motor cortex (M1). Seventeen measurement probes were centered over left M1. Subjects were studied in b...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00980.2011
更新日期:2013-03-01 00:00:00
abstract::Most of what we know about the neural control of gaze comes from experiments in head-fixed animals, but several "head-free" studies have suggested that fixing the head dramatically alters the apparent gaze command. We directly investigated this issue by quantitatively comparing head-fixed and head-free gaze trajectori...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00330.2003
更新日期:2003-10-01 00:00:00
abstract::The ability to adjust the amplitude of gaze shifts in response to persistent visual errors ("gaze adaptation") has been investigated primarily by introducing visual errors at the end of saccades produced by head-restrained primates. Very little is known about the behavior and neural mechanisms underlying gaze adaptati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90735.2008
更新日期:2009-01-01 00:00:00
abstract::1. Responses to pure tones were recorded from single neurons in the anteroventral cochlear nucleus (AVCN) in kittens ranging in age from 4 to 45 days. Different response properties mature at different times after birth. 2. The shapes of response areas of AVCN neurons after the 1st postnatal week resemble those recorde...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1978.41.6.1557
更新日期:1978-11-01 00:00:00
abstract::Here we report on the development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMmicroEs) that practically provide intracellular recordings and stimulation of many individual neurons, while the electrodes maintain an extracellular position. The develo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00265.2010
更新日期:2010-07-01 00:00:00
abstract::Across the rostrocaudal (RC) axis of the Xenopus tadpole optic tectum exists a developmental gradient. This gradient has served as a useful model to study many aspects of synapse and dendrite maturation. To compliment these studies, we characterized how the intrinsic excitability, the ease in which a neuron can fire a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00068.2014
更新日期:2014-10-01 00:00:00
abstract::Many critically ill patients in intensive care units suffer from an infection-induced whole body inflammatory state known as sepsis, which causes severe weakness in patients who survive. The mechanisms by which sepsis triggers intensive care unit-acquired weakness (ICUAW) remain unclear. Currently, research into ICUAW...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00936.2012
更新日期:2013-04-01 00:00:00
abstract::The effects of deep brain stimulation (DBS) on balance in people with Parkinson's disease (PD) are not well established. This study examined whether DBS randomized to the subthalamic nucleus (STN; n = 11) or globus pallidus interna (GPi; n = 10) improved compensatory stepping to recover balance after a perturbation. T...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,随机对照试验
doi:10.1152/jn.01052.2014
更新日期:2015-09-01 00:00:00
abstract::The aim of this study is to assess brain activity measured during continuous performance of design tracing tasks. Three issues were addressed: identification of brain areas involved in performing maze and square tracing tasks, investigation of differences and similarities in these areas related to dominant and nondomi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.4.2177
更新日期:1998-10-01 00:00:00
abstract::Head rotation, translation, and tilt with respect to a gravitational field elicit reflexive eye movements that partially stabilize images of Earth-fixed objects on the retinas of humans and other vertebrates. Compared with the angular vestibulo-ocular reflex, responses to translation and tilt, collectively called the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00882.2018
更新日期:2020-01-01 00:00:00
abstract::Rectification of surface EMG before spectral analysis is a well-established preprocessing method used in the detection of motor unit firing patterns. A number of recent studies have called into question the need for rectification before spectral analysis, pointing out that there is no supporting experimental evidence ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00296.2013
更新日期:2013-10-01 00:00:00
abstract::1. Outward currents in identified cell types from the pyloric system of the stomatogastric ganglion (STG) of the spiny lobster, Panulirus marginatus, were studied under two-microelectrode voltage clamp. A comparison was made between data from intact cells and somata isolated by ligation of the primary neurite of these...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.6.2056
更新日期:1993-06-01 00:00:00
abstract::1. We used period/amplitude (PA) analysis to survey electroencephalography (EEG) across vigilance states in the Sprague-Dawley rat. We found a fast cortical EEG frequency band, which we designate rho, whose wave amplitude in rapid eye movement (REM) was elevated above the levels in both waking and nonrapid eye movemen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.4.1368
更新日期:1993-04-01 00:00:00
abstract::Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement seque...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00054.2020
更新日期:2020-05-01 00:00:00
abstract::To study the possible role of the cerebellum in the vestibular-ocular reflex, extracellular responses of cerebellar nuclear neurons were recorded in awake monkeys during natural vestibular stimulation; 115 neurons in the fastigial nucleus responded to horizontal sinusoidal accelerations applied to the head by means of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.3.627
更新日期:1975-05-01 00:00:00
abstract::A quantitative analysis of activity-related calcium dynamics was performed in motoneurons of the nucleus hypoglossus in the brain stem slice preparation from mouse by simultaneous patch-clamp and microfluorometric calcium measurements. Motoneurons were analyzed under in vitro conditions that kept them in a functionall...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.6.2936
更新日期:1999-12-01 00:00:00