Dynamic spatiotemporal synaptic integration in cortical neurons: neuronal gain, revisited.

abstract：:In rats, whisker trimming during development leads to persistent alterations in the function of cortical barrel circuits and to behavioral deficits later in life. Here we examined how whisker trimming begun either at birth (P0) or on postnatal day 12 (P12), around the onset of whisking behavior, affects receptive fiel...

journal_title：Journal of neurophysiology

authors： Shoykhet M,Land PW,Simons DJ

更新日期：2005-12-01 00:00:00

abstract：:Working memory (WM) for sensory-based information about individual objects and their locations appears to involve interactions between lateral prefrontal and sensory cortexes. The mechanisms and representations for maintenance of more abstract, nonsensory information in WM are unknown, particularly whether such active...

journal_title：Journal of neurophysiology

authors： Ikkai A,Blacker KJ,Lakshmanan BM,Ewen JB,Courtney SM

更新日期：2014-10-15 00:00:00

abstract：:Trimming all whiskers except two on one side of an adult rat's face results in cortical plasticity in which the spared whiskers, D2 and one D-row surround whisker (either D1 or D3), evoked responses containing more spikes than the response evoked by the cut whisker (called whisker pairing plasticity). Previously we ha...

journal_title：Journal of neurophysiology

authors： Sachdev RN,Egli M,Stonecypher M,Wiley RG,Ebner FF

更新日期：2000-10-01 00:00:00

abstract：:Membrane-permeable arachidonic acid (AA) is liberated in a Ca2+-dependent way inside cells. By using whole cell patch clamp we show that intracellular AA (1 pM) selectively reduces IA in rat hippocampal neurons, whereas extracellular application requires a 10(6)-fold concentration. The nonmetabolized AA analogue ETYA ...

journal_title：Journal of neurophysiology

authors： Bittner K,Müller W

更新日期：1999-07-01 00:00:00

abstract：:1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor antagonists bicuculline or picrotoxin. 2. The voltage-sensitive dye RH 41...

journal_title：Journal of neurophysiology

authors： Sutor B,Hablitz JJ,Rucker F,ten Bruggencate G

更新日期：1994-10-01 00:00:00

abstract：:The physiological basis of flexion spasms in individuals after spinal cord injury (SCI) may involve alterations in the properties of spinal neurons in the flexion reflex pathways. We hypothesize that these changes would be manifested as progressive increases in reflex response with repetitive stimulus application (i.e...

journal_title：Journal of neurophysiology

authors： Hornby TG,Rymer WZ,Benz EN,Schmit BD

更新日期：2003-01-01 00:00:00

abstract：:A voluntary contraction of muscles with one arm increases the excitability of corticospinal projections to the contralateral resting arm, a phenomenon known as crossed facilitation. Although many motor tasks engage simultaneous activation of the arm and trunk, interactions between corticospinal projections targeting t...

journal_title：Journal of neurophysiology

authors： Chiou SY,Strutton PH,Perez MA

更新日期：2018-11-01 00:00:00

abstract：:1. Two subtypes of astrocytes that expressed distinctly different ion channel complements were identified in primary cultures from rat spinal cord and hippocampus using whole cell patch-clamp techniques. One population of cells expressed voltage-activated Na+ currents and displayed outwardly rectifying I-V relationshi...

journal_title：Journal of neurophysiology

authors： Ransom CB,Sontheimer H,Janigro D

更新日期：1996-07-01 00:00:00

abstract：:Distinguishing which of the many proposed neural mechanisms of spatial attention actually underlies behavioral improvements in visually guided tasks has been difficult. One attractive hypothesis is that attention allows downstream neural circuits to selectively integrate responses from the most informative sensory neu...

journal_title：Journal of neurophysiology

authors： Masse NY,Herrington TM,Cook EP

更新日期：2012-09-01 00:00:00

abstract：:Certain hand-held tools alter the mapping between hand motion and motion of the tool end point that must be controlled in order to perform a task. For example, when using a pool cue, the motion of the cue tip is reversed relative to the hand. Previous studies have shown that the time required to initiate a reaching mo...

journal_title：Journal of neurophysiology

authors： Baugh LA,Hoe E,Flanagan JR

更新日期：2012-10-01 00:00:00

abstract：:Layer IV of rodent primary somatosensory cortex is characterized by an array of whisker-related groups of neurons, known as "barrels." Neurons within each barrel respond best to a particular whisker on the contralateral face, and, on deflection of adjacent whiskers, display relatively weak excitation followed by stron...

journal_title：Journal of neurophysiology

authors： Goldreich D,Kyriazi HT,Simons DJ

更新日期：1999-09-01 00:00:00

abstract：:Substance P initiates locomotion when injected in the brain stem of mammals. This study examined the possible role of this peptide on the supraspinal locomotor command system in lampreys. Substance P was bath applied or locally injected into an in vitro isolated brain stem, and the effects of the drug were examined on...

journal_title：Journal of neurophysiology

authors： Brocard F,Bardy C,Dubuc R

更新日期：2005-04-01 00:00:00

abstract：:Mutual inhibition between the GABAergic cells of the thalamic reticular nucleus (RTN) is important in regulating oscillations in the thalamocortical network, promoting those in the spindle range of frequencies over those at lower frequencies. Excitatory inputs to the RTN from the cerebral cortex are numerically large ...

journal_title：Journal of neurophysiology

authors： Zhang L,Jones EG

更新日期：2004-02-01 00:00:00

abstract：:Paired-pulse transcranial magnetic stimulation (TMS) and peripheral stimulation combined with TMS can be used to study cortical interneuronal circuitry. By combining these procedures with concurrent transcranial alternating current stimulation (tACS), Guerra and colleagues recently showed that different cortical inter...

journal_title：Journal of neurophysiology

authors： Hussain SJ,Thirugnanasambandam N

更新日期：2017-06-01 00:00:00

abstract：:Trimming all but two whiskers in adult rats produces a predictable change in cortical cell-evoked responses characterized by increased responsiveness to the two intact whiskers and decreased responsiveness to the trimmed whiskers. This type of synaptic plasticity in rat somatic sensory cortex, called "whisker pairing ...

journal_title：Journal of neurophysiology

authors： Sachdev RN,Lu SM,Wiley RG,Ebner FF

更新日期：1998-06-01 00:00:00

abstract：:The potassium-chloride cotransporter 2 (KCC2) plays a role in epileptiform synchronization, but it remains unclear how it influences such a process. Here, we used tetrode recordings in the in vitro rat entorhinal cortex (EC) to analyze the effects of the KCC2 antagonist VU0463271 on 4-aminopyridine (4AP)-induced ictal...

journal_title：Journal of neurophysiology

authors： Chen LY,Lévesque M,Avoli M

更新日期：2019-09-01 00:00:00

abstract：:Voice onset time (VOT) is an important parameter of speech that denotes the time interval between consonant onset and the onset of low-frequency periodicity generated by rhythmic vocal cord vibration. Voiced stop consonants (/b/, /g/, and /d/) in syllable initial position are characterized by short VOTs, whereas unvoi...

journal_title：Journal of neurophysiology

authors： Steinschneider M,Volkov IO,Noh MD,Garell PC,Howard MA 3rd

更新日期：1999-11-01 00:00:00

abstract：:Our understanding of how we learn and retain motor behaviors is still limited. For instance, there is conflicting evidence as to whether the memory of a learned visuomotor perturbation consolidates; i.e., the motor memory becomes resistant to interference from learning a competing perturbation over time. Here, we soug...

journal_title：Journal of neurophysiology

authors： Maeda RS,McGee SE,Marigold DS

更新日期：2017-01-01 00:00:00

abstract：:Following peripheral nerve injury, moderate daily exercise conducted on a level treadmill results in enhanced axon regeneration and modest improvements in functional recovery. If the exercise is conducted on an upwardly inclined treadmill, even more motor axons regenerate successfully and reinnervate muscle targets. W...

journal_title：Journal of neurophysiology

authors： Cannoy J,Crowley S,Jarratt A,Werts KL,Osborne K,Park S,English AW

更新日期：2016-09-01 00:00:00

abstract：:For the first time in any vertebrate, in vivo responses of single olfactory receptor neurons to odorant mixtures were studied quantitatively. Extracellular electrophysiological response of 54 single olfactory receptor neurons from 23 channel catfish, Ictalurus punctatus, to binary mixtures of amino acids and to their ...

journal_title：Journal of neurophysiology

authors： Kang J,Caprio J

更新日期：1997-01-01 00:00:00

abstract：:Receptive fields of neurons in somatosensory area 3b of monkeys are typically described as restricted to part of a single digit or palm pad. However, such neurons are likely involved in integrating stimulus information from across the hand. To evaluate this possibility, we recorded from area 3b neurons in anesthetized...

journal_title：Journal of neurophysiology

authors： Reed JL,Qi HX,Zhou Z,Bernard MR,Burish MJ,Bonds AB,Kaas JH

更新日期：2010-04-01 00:00:00

abstract：:Previous behavioral work has shown the existence of both anticipatory and reactive grip force responses to predictable load perturbations, but how the brain implements anticipatory control remains unclear. Here we recorded electroencephalographs while participants were subjected to predictable and unpredictable extern...

journal_title：Journal of neurophysiology

authors： Kourtis D,Kwok HF,Roach N,Wing AM,Praamstra P

更新日期：2008-02-01 00:00:00

abstract：:This study of chronic incomplete spinal cord injury (SCI) subjects investigated patterns of central motor drive (i.e., central activation) of the plantar flexors using interpolated twitches, and modulation of soleus H-reflexes during lengthening, isometric, and shortening muscle actions. In a recent study of the knee ...

journal_title：Journal of neurophysiology

authors： Kim HE,Corcos DM,Hornby TG

更新日期：2015-07-01 00:00:00

abstract：:The mechanism(s) of olfactory transduction in invertebrates remains to be fully understood. In lobster olfactory receptor neurons (ORNs), a nonselective sodium-gated cation (SGC) channel, a presumptive transient receptor potential (TRP)C channel homolog, plays a crucial role in olfactory transduction, at least in part...

journal_title：Journal of neurophysiology

authors： Pezier A,Bobkov YV,Ache BW

更新日期：2009-03-01 00:00:00

abstract：:Cholinergic signaling coupled to sensory-driven neuronal depolarization is essential for modulating lasting changes in deep-layer neural excitability and experience-dependent plasticity in the primary auditory cortex. However, the underlying cellular mechanism(s) associated with coincident cholinergic receptor activat...

journal_title：Journal of neurophysiology

authors： Fu X,Ye H,Jia H,Wang X,Chomiak T,Luo F

更新日期：2019-12-01 00:00:00

abstract：:A large array of neuroscientific techniques, including in vivo electrophysiology, two-photon imaging, optogenetics, lesions, and microdialysis, require access to the brain through the skull. Ideally, the necessary craniotomies could be performed in a repeatable and automated fashion, without damaging the underlying br...

journal_title：Journal of neurophysiology

authors： Pak N,Siegle JH,Kinney JP,Denman DJ,Blanche TJ,Boyden ES

更新日期：2015-06-01 00:00:00

abstract：:We have investigated potential mechanisms by which exercise can promote changes in neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (BDNF), ...

journal_title：Journal of neurophysiology

authors： Gómez-Pinilla F,Ying Z,Roy RR,Molteni R,Edgerton VR

更新日期：2002-11-01 00:00:00

abstract：:Autoinhibitory serotonin 1A receptors (5-HT(1A)) in dorsal raphé nucleus (DRN) have been implicated in chronic depression and in actions of selective serotonin reuptake inhibitors (SSRI). Due to experimental limitations, it was never studied at single-cell level whether changes in 5-HT(1A) receptor functionality occur...

journal_title：Journal of neurophysiology

authors： Cornelisse LN,Van der Harst JE,Lodder JC,Baarendse PJ,Timmerman AJ,Mansvelder HD,Spruijt BM,Brussaard AB

更新日期：2007-07-01 00:00:00

abstract：:During walking, maintenance and coordination of activity in leg motoneurons requires intersegmental signal transfer. In a semi-intact preparation of the stick insect, we studied membrane potential modulations in mesothoracic (middle leg) motoneurons and local premotor nonspiking interneurons that were induced by stepp...

journal_title：Journal of neurophysiology

authors： Ludwar BCh,Westmark S,Büschges A,Schmidt J

更新日期：2005-10-01 00:00:00

abstract：:The purpose of this study was to examine changes in motor unit activity in the biceps brachii muscle after an initial (Bout 1) and repeated (Bout 2) session of eccentric exercise separated by 1 wk. Eight subjects (aged 22 ± 2 yr) participated in experimental assessments of neuromuscular function obtained before, immed...

journal_title：Journal of neurophysiology

authors： Dartnall TJ,Nordstrom MA,Semmler JG

更新日期：2011-03-01 00:00:00