Synapsin regulates Basal synaptic strength, synaptic depression, and serotonin-induced facilitation of sensorimotor synapses in Aplysia.

abstract：:Optogenetics combines optics and genetics to control neuronal activity with cell-type specificity and millisecond temporal precision. Its use in model organisms such as rodents, Drosophila, and Caenorhabditis elegans is now well-established. However, application of this technology in nonhuman primates (NHPs) has been ...

journal_title：Journal of neurophysiology

authors： Ruiz O,Lustig BR,Nassi JJ,Cetin A,Reynolds JH,Albright TD,Callaway EM,Stoner GR,Roe AW

更新日期：2013-09-01 00:00:00

abstract：:Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor (GABABR...

journal_title：Journal of neurophysiology

authors： Pennock RL,Hentges ST

更新日期：2016-06-01 00:00:00

abstract：:Reaching movements are subject to noise associated with planning and execution, but precisely how these noise sources interact to determine patterns of endpoint variability in three-dimensional space is not well understood. For frontal plane movements, variability is largest along the depth axis (the axis along which ...

journal_title：Journal of neurophysiology

authors： Apker GA,Buneo CA

更新日期：2012-01-01 00:00:00

abstract：:The human ventral visual pathway is implicated in higher order form processing, but the organizational principles within this region are not yet well understood. Recently, Lafer-Sousa, Conway, and Kanwisher (J Neurosci 36: 1682-1697, 2016) used functional magnetic resonance imaging to demonstrate that functional respo...

journal_title：Journal of neurophysiology

authors： Goddard E

更新日期：2017-03-01 00:00:00

abstract：:1. Single- and multiunit recordings were obtained from neurons in the auditory cortex of the echolocating bat Myotis lucifugus, while trains of stimuli designed to simulate the bat's frequency-modulated (FM) orientation pulse and its returning echo were delivered. It was found that many neurons in the cortex responded...

journal_title：Journal of neurophysiology

authors： Sullivan WE 3rd

更新日期：1982-10-01 00:00:00

abstract：:Cross-orientation suppression was measured in human primary visual cortex (V1) to test the normalization model. Subjects viewed vertical target gratings (of varying contrasts) with or without a superimposed horizontal mask grating (fixed contrast). We used functional magnetic resonance imaging (fMRI) to measure the ac...

journal_title：Journal of neurophysiology

authors： Brouwer GJ,Heeger DJ

更新日期：2011-11-01 00:00:00

abstract：:The intrinsic properties of tonically firing neurons in the cochlear nucleus contribute to representing average sound intensity by favoring synaptic integration across auditory nerve inputs, reducing phase locking to fine temporal acoustic structure and enhancing envelope locking. To determine whether tonically firing...

journal_title：Journal of neurophysiology

authors： Kreeger LJ,Arshed A,MacLeod KM

更新日期：2012-11-01 00:00:00

abstract：:Odorants induce specific modulation of mitral/tufted (MT) cells' firing rate in the mammalian olfactory bulb (OB), inducing temporal patterns of neuronal discharge embedded in an oscillatory local field potential (LFP). While most studies have examined anesthetized animals, little is known about the firing rate and te...

journal_title：Journal of neurophysiology

authors： Fuentes RA,Aguilar MI,Aylwin ML,Maldonado PE

更新日期：2008-07-01 00:00:00

abstract：:The role of potassium channels in regulating spontaneous firing and sound-evoked responses in the central nucleus of the inferior colliculus was studied by recording single-unit activity before and during iontophoretic application of a nonspecific potassium channel blocker, tetraethylammonium (TEA). Tone bursts and si...

journal_title：Journal of neurophysiology

authors： Zhang H,Wu SH,Kelly JB

更新日期：2004-05-01 00:00:00

abstract：:Searching for items that are useful given current goals, or "target" recognition, requires observers to flexibly attend to certain object properties at the expense of others. This could involve focusing on the identity of an object while ignoring identity-preserving transformations such as changes in viewpoint or focu...

journal_title：Journal of neurophysiology

authors： Henderson M,Serences JT

更新日期：2019-04-01 00:00:00

abstract：:Single-unit activity of the motor cortex (area 4gamma) was studied in cats performing reaching with the contra- versus ipsilateral forelimb. Reaching was initiated by a tone burst (Go cue), different limbs were used in separate blocks of trials. During reaching performed with the contralateral limb, three types of neu...

journal_title：Journal of neurophysiology

authors： Perfiliev S

更新日期：2005-05-01 00:00:00

abstract：:Overestimation of roll tilt in hypergravity ("G-excess" illusion) has been demonstrated, but corresponding sustained hypogravic conditions are impossible to create in ground laboratories. In this article we describe the first systematic experimental evidence that in a hypogravity analog, humans underestimate roll tilt...

journal_title：Journal of neurophysiology

authors： Galvan-Garza RC,Clark TK,Sherwood D,Diaz-Artiles A,Rosenberg M,Natapoff A,Karmali F,Oman CM,Young LR

更新日期：2018-12-01 00:00:00

abstract：:The cerebellum has long been recognized to play an important role in motor adaptation. Individuals with cerebellar ataxia exhibit impaired learning in visuomotor adaptation tasks such as prism adaptation and force field learning. Both types of tasks involve the adjustment of an internal model to compensate for an exte...

journal_title：Journal of neurophysiology

authors： Schlerf JE,Xu J,Klemfuss NM,Griffiths TL,Ivry RB

更新日期：2013-02-01 00:00:00

abstract：:Sensory areas should be adapted to the properties of their natural stimuli. What are the underlying rules that match the properties of complex cells in primary visual cortex to their natural stimuli? To address this issue, we sampled movies from a camera carried by a freely moving cat, capturing the dynamics of image ...

journal_title：Journal of neurophysiology

authors： Körding KP,Kayser C,Einhäuser W,König P

更新日期：2004-01-01 00:00:00

abstract：:In contrast to hand movements, the existence of a neural representation of saccade kinematics is unclear. Saccade kinematics is typically thought to be specified by motor error/desired displacement and generated by brain stem circuits that are not penetrable to voluntary control. We studied the influence of instructed...

journal_title：Journal of neurophysiology

authors： Gopal A,Jana S,Murthy A

更新日期：2017-09-01 00:00:00

abstract：:Generalizing newly learned movement patterns beyond the training context is challenging for most motor learning situations. Here we tested whether learning of a new physical property of the arm during self-initiated reaching generalizes to new arm configurations. Human participants performed a single-joint elbow reach...

journal_title：Journal of neurophysiology

authors： Maeda RS,Zdybal JM,Gribble PL,Pruszynski JA

更新日期：2020-03-01 00:00:00

abstract：:1. We studied the blocking properties of a spider (Nephila clavata) toxin (JSTX) purified from venom on the spiny lobster neuromuscular junction. 2. When a small amount of JSTX was applied to the neuromuscular junction, the excitatory postsynaptic potential (EPSP) was partially suppressed. The amplitude of EPSPs remai...

journal_title：Journal of neurophysiology

authors： Miwa A,Kawai N,Saito M,Pan-Hou H,Yoshioka M

更新日期：1987-08-01 00:00:00

abstract：:1. The simplicity of the jellyfish nervous system makes it an ideal preparation to assess the contributions of different ion channels to behavior. In the giant motor axons of the jellyfish Aglantha digitale, low-threshold spikes elicit slow swimming, whereas escape swimming depends on a higher-threshold, overshooting ...

journal_title：Journal of neurophysiology

authors： Meech RW,Mackie GO

更新日期：1993-03-01 00:00:00

abstract：:The objectives of this study were to probe the contribution of spinal neuron persistent sodium conductances to reflex hyperexcitability in human chronic spinal cord injury. The intrinsic excitability of spinal neurons provides a novel target for medical intervention. Studies in animal models have shown that persistent...

journal_title：Journal of neurophysiology

authors： Theiss RD,Hornby TG,Rymer WZ,Schmit BD

更新日期：2011-06-01 00:00:00

abstract：:Pain signals threat and initiates motor responses to avoid harm. The transformation of pain into a motor response is thus an essential part of pain. Here, we investigated the neural mechanisms subserving the sensorimotor transformation of pain at the cortical level by using electroencephalography. In a simple reaction...

journal_title：Journal of neurophysiology

authors： Schulz E,Tiemann L,Witkovsky V,Schmidt P,Ploner M

更新日期：2012-08-01 00:00:00

abstract：:Voltage-activated currents in blue cones of the retinal slice of zebrafish were characterized using whole cell recording techniques. Depolarizing-elicited currents were recorded: an outward tetraethylammonium (TEA)-sensitive K+ current (IKx), an outward Ca(2+)-activated Cl- current (ICl(Ca)), from which we inferred an...

journal_title：Journal of neurophysiology

authors： Fan SF,Yazulla S

更新日期：1997-03-01 00:00:00

abstract：:The effect of HCO(3)(-)/CO(2) on membrane properties of isolated hippocampal CA1 neurons was studied with the use of the whole cell configuration of the patch-clamp technique. Neurons were acutely dissociated from 21- to 30-day-old mice. In the current-clamp mode, HCO(3)(-)/CO(2) significantly hyperpolarized CA1 neuro...

journal_title：Journal of neurophysiology

authors： Gu XQ,Yao H,Haddad GG

更新日期：2000-11-01 00:00:00

abstract：:We studied two human subjects with total deafferentation of one upper limb secondary to traumatic multiple cervical root avulsions. Both subjects developed a phantom limb and underwent elective amputation of the paralyzed, deafferentated limb. Psychophysical study revealed in each subject an area of skin in the pector...

journal_title：Journal of neurophysiology

authors： Kew JJ,Halligan PW,Marshall JC,Passingham RE,Rothwell JC,Ridding MC,Marsden CD,Brooks DJ

更新日期：1997-05-01 00:00:00

abstract：:Increasing evidence demonstrates that modulating the cGMP-dependent protein kinase G (PKG) pathway produces an array of behavioral phenotypes in the fruit fly, Drosophila melanogaster. Altering PKG activity, either genetically via the foraging (for) gene or using pharmacology modifies tolerance to acute abiotic stress...

journal_title：Journal of neurophysiology

authors： Caplan SL,Milton SL,Dawson-Scully K

更新日期：2013-02-01 00:00:00

abstract：:1. In alpha-chloralose-anesthetized cats the region surrounding the ventral posterolateral nucleus (VPL) of the thalamus was investigated to locate foci with input from the urinary bladder stimulated by application of intravesical pressure. The locations of the recording sites were verified in Nissl-stained histologic...

journal_title：Journal of neurophysiology

authors： Brüggemann J,Vahle-Hinz C,Kniffki KD

更新日期：1993-08-01 00:00:00

abstract：:1. The aim of this study was to characterize the signals transmitted by neurons of the medial vestibular nucleus (MVN) to the middle zone of the flocculus in alert cats. 2. Bipolar stimulating electrodes were implanted into the middle zone of each flocculus, because this zone is known to be involved in the control of ...

journal_title：Journal of neurophysiology

authors： Cheron G,Escudero M,Godaux E

更新日期：1996-09-01 00:00:00

abstract：:Electrical transmission is a dynamically regulated form of communication and key to synchronizing neuronal activity. The bag cell neurons of Aplysia are a group of electrically coupled neuroendocrine cells that initiate ovulation by secreting egg-laying hormone during a prolonged period of synchronous firing called th...

journal_title：Journal of neurophysiology

authors： Dargaei Z,Standage D,Groten CJ,Blohm G,Magoski NS

更新日期：2015-02-01 00:00:00

abstract：:There are at least two respiration-related rhythm generators in the medulla: the pre-Bötzinger complex, which produces inspiratory (Insp) neuron bursts, and the parafacial respiratory group (pFRG), which produces predominantly preinspiratory (Pre-I) neuron bursts. The pFRG Pre-I neuron activity has not been correlated...

journal_title：Journal of neurophysiology

authors： Onimaru H,Kumagawa Y,Homma I

更新日期：2006-07-01 00:00:00

abstract：:Electrical stimulation of the median nerve at the wrist may elicit a blink reflex [hand blink reflex (HBR)] mediated by a neural circuit at brain stem level. As, in a Sherringtonian sense, the blink reflex is a defensive response, in a series of experiments we tested, in healthy volunteers, whether and how the HBR is ...

journal_title：Journal of neurophysiology

authors： Sambo CF,Liang M,Cruccu G,Iannetti GD

更新日期：2012-02-01 00:00:00

abstract：:The discovery that spontaneous fluctuations in blood oxygen level-dependent (BOLD) signals contain information about the functional organization of the brain has caused a paradigm shift in neuroimaging. It is now well established that intrinsic brain activity is organized into spatially segregated resting-state networ...

journal_title：Journal of neurophysiology

authors： Mitra A,Snyder AZ,Hacker CD,Raichle ME

更新日期：2014-06-01 00:00:00