Ca2+-induced uncoupling of Aplysia bag cell neurons.

Abstract:

:Electrical transmission is a dynamically regulated form of communication and key to synchronizing neuronal activity. The bag cell neurons of Aplysia are a group of electrically coupled neuroendocrine cells that initiate ovulation by secreting egg-laying hormone during a prolonged period of synchronous firing called the afterdischarge. Accompanying the afterdischarge is an increase in intracellular Ca2+ and the activation of protein kinase C (PKC). We used whole cell recording from paired cultured bag cell neurons to demonstrate that electrical coupling is regulated by both Ca2+ and PKC. Elevating Ca2+ with a train of voltage steps, mimicking the onset of the afterdischarge, decreased junctional current for up to 30 min. Inhibition was most effective when Ca2+ entry occurred in both neurons. Depletion of Ca2+ from the mitochondria, but not the endoplasmic reticulum, also attenuated the electrical synapse. Buffering Ca2+ with high intracellular EGTA or inhibiting calmodulin kinase prevented uncoupling. Furthermore, activating PKC produced a small but clear decrease in junctional current, while triggering both Ca2+ influx and PKC inhibited the electrical synapse to a greater extent than Ca2+ alone. Finally, the amplitude and time course of the postsynaptic electrotonic response were attenuated after Ca2+ influx. A mathematical model of electrically connected neurons showed that excessive coupling reduced recruitment of the cells to fire, whereas less coupling led to spiking of essentially all neurons. Thus a decrease in electrical synapses could promote the afterdischarge by ensuring prompt recovery of electrotonic potentials or making the neurons more responsive to current spreading through the network.

journal_name

J Neurophysiol

authors

Dargaei Z,Standage D,Groten CJ,Blohm G,Magoski NS

doi

10.1152/jn.00603.2014

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

808-21

issue

3

eissn

0022-3077

issn

1522-1598

pii

jn.00603.2014

journal_volume

113

pub_type

杂志文章
  • Effects of leg pedaling on early latency cutaneous reflexes in upper limb muscles.

    abstract::The functional coupling of neural circuits between the upper and lower limbs involving rhythmic movements is of interest to both motor control research and rehabilitation science. This coupling can be detected by examining the effect of remote rhythmic limb movement on the modulation of reflex amplitude in stationary ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00774.2009

    authors: Sasada S,Tazoe T,Nakajima T,Zehr EP,Komiyama T

    更新日期:2010-07-01 00:00:00

  • Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons.

    abstract::The contributions of the hyperpolarization-activated current, I(h), to generation of rhythmic activities are well described for various central neurons, particularly in thalamocortical circuits. In the present study, we investigated effects of a general anesthetic, propofol, on native I(h) in neurons of thalamus and c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00389.2005

    authors: Chen X,Shu S,Bayliss DA

    更新日期:2005-12-01 00:00:00

  • Defensive peripersonal space: the blink reflex evoked by hand stimulation is increased when the hand is near the face.

    abstract::Electrical stimulation of the median nerve at the wrist may elicit a blink reflex [hand blink reflex (HBR)] mediated by a neural circuit at brain stem level. As, in a Sherringtonian sense, the blink reflex is a defensive response, in a series of experiments we tested, in healthy volunteers, whether and how the HBR is ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00731.2011

    authors: Sambo CF,Liang M,Cruccu G,Iannetti GD

    更新日期:2012-02-01 00:00:00

  • Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons.

    abstract::Pharmacological modulation of gamma-aminobutyric acid-A (GABAA) receptors can provide important information on the types of subunits composing these receptors. In recombinant studies, zinc more potently inhibits alphabeta subunits compared with the alphabetagamma combination, whereas modulation by nanomolar concentrat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.4.1670

    authors: Defazio T,Hablitz JJ

    更新日期:1998-10-01 00:00:00

  • Cyclic nucleotide-activated currents in cultured olfactory receptor neurons of the hawkmoth Manduca sexta.

    abstract::Moth pheromones cause rises in intracellular Ca(2+) concentrations that activate Ca(2+)-dependent cation channels in antennal olfactory receptor neurons. In addition, mechanisms of adaptation and sensitization depend on changes in cyclic nucleotide concentrations. Here, cyclic nucleotide-activated currents in cultured...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01400.2007

    authors: Krannich S,Stengl M

    更新日期:2008-11-01 00:00:00

  • Differences in time course of ACh and GABA modulation of excitatory synaptic potentials in slices of rat hippocampus.

    abstract::Activation of muscarinic receptors and GABA(B) receptors causes presynaptic inhibition of glutamatergic synaptic potentials at excitatory feedback connections in cortical structures. These effects may regulate dynamics in cortical structures, with presynaptic inhibition allowing extrinsic afferent input to dominate du...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.4.1792

    authors: Hasselmo ME,Fehlau BP

    更新日期:2001-10-01 00:00:00

  • Transfer of motor performance in an obstacle avoidance task to different walking conditions.

    abstract::The aim of this study was to examine whether subjects who have learned a skilled locomotor task can transfer the acquired performance to conditions involving either a change in the external coordinates or in the sensory input from one leg. Subjects were trained to step over an obstacle with minimal foot clearance with...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00397.2004

    authors: Lam T,Dietz V

    更新日期:2004-10-01 00:00:00

  • Swimming rhythm generation in the caudal hindbrain of the lamprey.

    abstract::The spinal cord has been well established as the site of generation of the locomotor rhythm in vertebrates, but studies have suggested that the caudal hindbrain in larval fish and amphibians can also generate locomotor rhythms. Here, we investigated whether the caudal hindbrain of the adult lamprey ( Petromyzon marinu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00851.2017

    authors: Buchanan JT

    更新日期:2018-05-01 00:00:00

  • Histidine-rich basic peptide: a cardioactive neuropeptide from Aplysia neurons R3-14.

    abstract::We have previously demonstrated that neurons R3-14 of the Aplysia abdominal ganglia specifically express a gene encoding a 108-amino acid neuropeptide precursor. This precursor is postranslationally processed by cleavage of a signal sequence and two internal dibasic residues resulting in three peptides. The peptide pr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.4.1201

    authors: Campanelli JT,Scheller RH

    更新日期:1987-04-01 00:00:00

  • The development of transmission at an identified molluscan synapse. II. A quantal analysis of transmission.

    abstract::1. A quantal analysis of transmission at the identified molluscan synapse, V2-RPr1, was performed during development. The study was intended to determine the pre- and postsynaptic contributions to the marked changes in transmitter release described in the previous report. 2. The success of the quantal analysis was pre...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.6.2211

    authors: Pawson PA,Chase R

    更新日期:1988-12-01 00:00:00

  • Cortical mechanisms underlying tactile discrimination in the monkey. I. Role of primary somatosensory cortex in passive texture discrimination.

    abstract::1. The discharge patterns of 359 single neurons in the hand representation of primary somatosensory cortex (SI) of two monkeys (Macaca mulatta) were recorded during the performance of a passive texture discrimination task with the contralateral hand (104 in area 3b, 149 in area 1, and 106 in area 2). Three nyloprint s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.5.3382

    authors: Tremblay F,Ageranioti-Bélanger SA,Chapman CE

    更新日期:1996-11-01 00:00:00

  • Attention and memory-related responses of neurons in the lateral intraparietal area during spatial and shape-delayed match-to-sample tasks.

    abstract::When a monkey attends to, remembers, and looks toward targets, the activity of some neurons in the lateral intraparietal area (LIP) changes. We recorded from isolated neurons during both a spatial and a shape match-to-sample task to examine and characterize voluntary active processes in LIP. Many LIP neurons show spat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00431.2005

    authors: Sereno AB,Amador SC

    更新日期:2006-02-01 00:00:00

  • Spatially selective enhancement of proprioceptive acuity following motor learning.

    abstract::It is well recognized that the brain uses sensory information to accurately produce motor commands. Indeed, most research into the relationship between sensory and motor systems has focused on how sensory information modulates motor function. In contrast, recent studies have begun to investigate the reverse: how senso...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00949.2010

    authors: Wong JD,Wilson ET,Gribble PL

    更新日期:2011-05-01 00:00:00

  • Regulation of the crab heartbeat by FMRFamide-like peptides: multiple interacting effects on center and periphery.

    abstract::We are studying the functional "logic" of neuromodulatory actions in a simple central pattern generator (CPG)-effector system, the heart of the blue crab Callinectes sapidus. The rhythmic contractions of this heart are neurogenic, driven by rhythmic motor patterns generated by the cardiac ganglion (CG). Here we used a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00558.2007

    authors: Fort TJ,Brezina V,Miller MW

    更新日期:2007-11-01 00:00:00

  • Annexin I is a local mediator in neural-endocrine feedback control of inflammation.

    abstract::Annexin I is a local mediator in neural-endocrine feedback control of inflammation. J. Neurophysiol. 80: 3120-3126, 1998. Activation of primary afferent nociceptors induces a neural endocrine-mediated inhibition of the inflammatory response via a circuit that includes ascending spinal pathways and activation of the hy...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.6.3120

    authors: Green PG,Strausbaugh HJ,Levine JD

    更新日期:1998-12-01 00:00:00

  • Preserved high-centrality hubs but efficient network reorganization during eyes-open state compared with eyes-closed resting state: an MEG study.

    abstract::A question to be addressed in the present study is how different the eyes-closed (EC) and eyes-open (EO) resting states are across frequency bands in terms of efficiency and centrality of the brain functional network. We investigated both the global and nodal efficiency and betweenness centrality in the EC and EO rest...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00585.2013

    authors: Jin SH,Jeong W,Lee DS,Jeon BS,Chung CK

    更新日期:2014-04-01 00:00:00

  • Rapid visuomotor feedback gains are tuned to the task dynamics.

    abstract::Adaptation to novel dynamics requires learning a motor memory, or a new pattern of predictive feedforward motor commands. Recently, we demonstrated the upregulation of rapid visuomotor feedback gains early in curl force field learning, which decrease once a predictive motor memory is learned. However, even after learn...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00748.2016

    authors: Franklin S,Wolpert DM,Franklin DW

    更新日期:2017-11-01 00:00:00

  • Correlated firing of cat retinal ganglion cells. I. Spontaneously active inputs to X- and Y-cells.

    abstract::1. The shared inputs to cat retinal ganglion cells have been investigated by studying correlations in the maintained firing of neighboring ganglion cells. The firing of one cell was recorded from its axon in the optic tract, while that of a neighboring cell was simultaneously recorded with a second electrode in the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.49.2.303

    authors: Mastronarde DN

    更新日期:1983-02-01 00:00:00

  • The spread of attention across features of a surface.

    abstract::Contrasting theories of visual attention have emphasized selection by spatial location, individual features, and whole objects. We used functional magnetic resonance imaging to ask whether and how attention to one feature of an object spreads to other features of the same object. Subjects viewed two spatially superimp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00828.2012

    authors: Ernst ZR,Boynton GM,Jazayeri M

    更新日期:2013-11-01 00:00:00

  • Cerebellar control of saccade dynamics: contribution of the fastigial oculomotor region.

    abstract::The fastigial oculomotor region is the output by which the medioposterior cerebellum influences the generation of saccades. Recent inactivation studies reported observations suggesting an involvement in their dynamics (velocity and duration). In this work, we tested this hypothesis in the head-restrained monkey with t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01021.2014

    authors: Quinet J,Goffart L

    更新日期:2015-05-01 00:00:00

  • Optical recording of neuronal activity in an invertebrate central nervous system: simultaneous monitoring of several neurons.

    abstract::1. Using an optical method for measuring membrane potential, we have been able to monitor action-potential activity simultaneously in 14 neurons of the supraesophageal ganglion of the barnacle. 2. Under favorable conditions, 4-mV synaptic potentials could also be detected optically. ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1977.40.6.1281

    authors: Salzberg BM,Grinvald A,Cohen LB,Davila HV,Ross WN

    更新日期:1977-11-01 00:00:00

  • Substance P depresses excitatory synaptic transmission in the nucleus accumbens through dopaminergic and purinergic mechanisms.

    abstract::Substance P (SP) is an undecapeptide that is co-localized with conventional transmitters in the nucleus accumbens (NAc). Its neurochemical and behavioral effects resemble those of cocaine and amphetamine. How SP accomplishes these effects is not known, partly because its cellular and synaptic effects are not well char...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00854.2002

    authors: Kombian SB,Ananthalakshmi KV,Parvathy SS,Matowe WC

    更新日期:2003-02-01 00:00:00

  • Risky business: disambiguating ambiguity-related responses in the brain.

    abstract::Previous functional MRI studies reported neural correlates of risk and ambiguity based on behavioral economic theories. A recent study controlled for uncertainty by adding noise to information of an impending aversive event and demonstrated brain areas that did not track the degree of uncertainty: the activation peake...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00406.2009

    authors: O'Neill M,Kobayashi S

    更新日期:2009-08-01 00:00:00

  • Humans sacrifice decision-making for action execution when a demanding control of movement is required.

    abstract::A growing body of evidence suggests that decision-making and action execution are governed by partly overlapping operating principles. Especially, previous work proposed that a shared decision urgency/movement vigor signal, possibly computed in the basal ganglia, coordinates both deliberation and movement durations in...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00220.2020

    authors: Reynaud AJ,Saleri Lunazzi C,Thura D

    更新日期:2020-08-01 00:00:00

  • NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus.

    abstract::1. We have examined the effects of iontophoresing specific antagonists to excitatory amino acid receptors on the visual responses of cells in lamina A or A1 of the cat's lateral geniculate nucleus (LGN). 2. Cells were classified as On- or Off-center, X or Y, and lagged or nonlagged. The effects of antagonists were stu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.2.414

    authors: Kwon YH,Esguerra M,Sur M

    更新日期:1991-08-01 00:00:00

  • Effect of cerebellar inactivation by lidocaine microdialysis on the vestibuloocular reflex in goldfish.

    abstract::Vestibuloocular reflex performance and adaptation were examined during vestibulocerebellar inactivation by localized lidocaine microdialysis or injection in goldfish. In the light, eye velocity perfectly compensated for head velocity (Vis-VOR) during sinusoidal yaw rotation (1/8 Hz +/- 20 degrees). In the dark, the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.3.1286

    authors: McElligott JG,Beeton P,Polk J

    更新日期:1998-03-01 00:00:00

  • Propagation of spindle waves in a thalamic slice model.

    abstract::1. We study the propagation and dynamics of spindle waves in thalamic slices by developing and analyzing a model of reciprocally coupled populations of excitatory thalamocortical (TC) neurons and inhibitory thalamic reticular (RE) neurons. 2. Each TC neuron has three intrinsic ionic currents: a low-threshold T-type Ca...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.2.750

    authors: Golomb D,Wang XJ,Rinzel J

    更新日期:1996-02-01 00:00:00

  • Encoder adaptation modulates the visual responses of crayfish interneurons.

    abstract::The responses of sustaining and dimming fibers were characterized by the time varying firing rates elicited by extrinsic current and flashes of light. These data were simulated by an adaptive integrate-and-fire model. A postimpulse shunt conductance simulated spike-frequency adaptation. The correlation between observe...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00035.2004

    authors: Glantz RM,Schroeter JP

    更新日期:2004-07-01 00:00:00

  • The parabrachial area: electrophysiological evidence for an involvement in visceral nociceptive processes.

    abstract::1. Neurons (n = 142) were recorded with extracellular micropipettes in the parabrachial (PB) area, in the anesthetized rat, some of them being antidromically driven from the centralis nucleus of the amygdala (Ce). The spontaneous activity of these neurons was low, (10th percentile < median frequency < 90th percentile;...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.5.1646

    authors: Bernard JF,Huang GF,Besson JM

    更新日期:1994-05-01 00:00:00

  • The quality of visual information about the lower extremities influences visuomotor coordination during virtual obstacle negotiation.

    abstract::Successful negotiation of obstacles during walking relies on the integration of visual information about the environment with ongoing locomotor commands. When information about the body and the environment is removed through occlusion of the lower visual field, individuals increase downward head pitch angle, reduce fo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00931.2017

    authors: Kim A,Kretch KS,Zhou Z,Finley JM

    更新日期:2018-08-01 00:00:00