Annexin I is a local mediator in neural-endocrine feedback control of inflammation.

Abstract:

:Annexin I is a local mediator in neural-endocrine feedback control of inflammation. J. Neurophysiol. 80: 3120-3126, 1998. Activation of primary afferent nociceptors induces a neural endocrine-mediated inhibition of the inflammatory response via a circuit that includes ascending spinal pathways and activation of the hypothalamic-pituitary adrenal (HPA) axis. This circuit inhibits sympathetic neuron-dependent plasma extravasation (PE) in the rat knee joint produced by bradykinin (BK), but not sympathetic neuron-independent PE produced by platelet activating factor (PAF). Noxious (25 mA) but not non-noxious (2.5 mA) electrical stimulation significantly increased plasma corticosterone concentrations, and intravenous infusion of corticosterone (5 micrograms/min) mimicked inhibition of BK-induced PE produced by noxious stimulation. However, perfusion of corticosterone locally through the knee joint, at doses that do not have a systemic action (i.e.,

journal_name

J Neurophysiol

authors

Green PG,Strausbaugh HJ,Levine JD

doi

10.1152/jn.1998.80.6.3120

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

3120-6

issue

6

eissn

0022-3077

issn

1522-1598

journal_volume

80

pub_type

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