Abstract:
:Annexin I is a local mediator in neural-endocrine feedback control of inflammation. J. Neurophysiol. 80: 3120-3126, 1998. Activation of primary afferent nociceptors induces a neural endocrine-mediated inhibition of the inflammatory response via a circuit that includes ascending spinal pathways and activation of the hypothalamic-pituitary adrenal (HPA) axis. This circuit inhibits sympathetic neuron-dependent plasma extravasation (PE) in the rat knee joint produced by bradykinin (BK), but not sympathetic neuron-independent PE produced by platelet activating factor (PAF). Noxious (25 mA) but not non-noxious (2.5 mA) electrical stimulation significantly increased plasma corticosterone concentrations, and intravenous infusion of corticosterone (5 micrograms/min) mimicked inhibition of BK-induced PE produced by noxious stimulation. However, perfusion of corticosterone locally through the knee joint, at doses that do not have a systemic action (i.e., =1 microM), did not inhibit BK-induced PE. Annexin I (lipocortin-1), a 37-kDa member of a family of phospholipid and calcium binding proteins, can mediate local anti-inflammatory effects of glucocorticoids via a mechanism that is partially dependent on inhibition of phospholipase A2 activity and adhesion and transmigration of polymorphonuclear leukocytes. Because BK-induced PE is dependent on both polymorphonuclear leukocytes and phospholipase A2 activity, we tested the hypothesis that the action of corticosterone to inhibit BK-induced PE is mediated by stimulating the production and release of annexin I. Perfusion of BK (150 nM) through the rat knee joint induces a rapid and sustained increase in PE. Co-perfusion of BK with annexin I (100 ng/ml) through the knee joint mimics the inhibition of BK-induced PE produced by noxious electrical stimulation or by intravenous corticosterone. Co-perfusion of BK with annexin I antibody (LCPS1, 1:60 dilution) prevented the inhibition of BK-induced PE produced by noxious electrical stimulation or intravenous corticosterone adminstration. PAF-induced PE, which is not dependent on polymorphonuclear leukocytes, was not inhibited by local perfusion of annexin I. These data suggest that the inhibitory effect of C-fiber activity on BK-induced PE, acting via an HPA circuit, is mediated by annexin I in the knee joint.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Green PG,Strausbaugh HJ,Levine JDdoi
10.1152/jn.1998.80.6.3120subject
Has Abstractpub_date
1998-12-01 00:00:00pages
3120-6issue
6eissn
0022-3077issn
1522-1598journal_volume
80pub_type
杂志文章abstract::The macaque middle temporal area (MT) is exquisitely sensitive to visual motion and there is a large amount of evidence that neural activity in MT is tightly correlated with the perception of motion. The mechanisms by which MT neurons achieve their directional selectivity, however, have received considerably less atte...
journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
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doi:10.1152/jn.1997.78.5.2811
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pub_type: 杂志文章
doi:10.1152/jn.1991.65.6.1528
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.55.4.678
更新日期:1986-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1152/jn.2001.86.1.86
更新日期:2001-07-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00796.2011
更新日期:2012-07-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.4.1611
更新日期:1994-10-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.2.1003
更新日期:1997-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1152/jn.1996.75.3.967
更新日期:1996-03-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of neurophysiology
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pub_type: 杂志文章
doi:10.1152/jn.1997.77.6.3226
更新日期:1997-06-01 00:00:00
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更新日期:2007-08-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.4.2208
更新日期:1998-04-01 00:00:00
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更新日期:2002-10-01 00:00:00
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journal_title:Journal of neurophysiology
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更新日期:1984-02-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1989-02-01 00:00:00
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journal_title:Journal of neurophysiology
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更新日期:1997-10-01 00:00:00
abstract::1. The fast extensor tibiae motor neuron makes direct excitatory central connections with the posterior group of flexor tibiae motor neurons in the locust metathoracic ganglion. The flexor group has a slow, a fast, and an intermediate motor neuron. The motor neurons are involved in the motor program for kicking and ju...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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