Abstract:
:One-hertz repetitive transcranial magnetic stimulation (1Hz-rTMS) over ipsilateral motor cortex is able to modify up to 30 min the motor performance of repetitive finger opposition movements paced with a metronome at 2 Hz. We investigated whether the long-lasting rTMS effect on motor behavior can be modulated by subsequent engagement of the contralateral sensorimotor system. Motor task was performed in different experimental conditions: immediately after rTMS, 30 min after rTMS, or when real rTMS was substituted with sham rTMS. Subjects performing the motor task immediately after rTMS showed modifications in motor behavior < or =30 min after rTMS. On the other hand, when real rTMS was substituted with sham stimulation or when subjects performed the motor task 30 min after the rTMS session, the effect was no longer present. These findings suggest that the combination of ipsilateral 1Hz-rTMS and voluntary movement is crucial to endure the effect of rTMS on the movement itself, probably acting on synaptic plasticity-like mechanism. This finding might provide some useful hints for neurorehabilitation protocols.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Avanzino L,Bove M,Tacchino A,Trompetto C,Ogliastro C,Abbruzzese Gdoi
10.1152/jn.90428.2008subject
Has Abstractpub_date
2009-03-01 00:00:00pages
1690-4issue
3eissn
0022-3077issn
1522-1598pii
90428.2008journal_volume
101pub_type
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