L-glutamic acid, a possible neurotransmitter to anterior aorta of Aplysia.

Abstract:

:The effect of L-glutamate on muscle fibers of the anterior aorta of the marine gastropod Aplysia are characterized. Iontophoretically applied L-glutamate depolarized anterior aorta muscle fibers in 14% of the applications; no response was detected in the other applications. Responses to iontophoretically applied L-glutamate desensitize rapidly and are antagonized by 2-amino-4-phosphonobutyric acid (2-APB). 2-APB also blocked excitatory junctional potentials (EJPs) in the anterior aorta. No significant response to D-glutamate was observed. These characteristics match those of L-glutamate at the arthropod neuromuscular junction. Bath-applied L-glutamate also depolarizes anterior aorta muscle fibers, by a mechanism clearly different from that of iontophoretically applied L-glutamate. Present results make L-glutamate a candidate neurotransmitter to molluscan circulatory muscles.

journal_name

J Neurophysiol

authors

Sawada M,Gibson D,McAdoo DJ

doi

10.1152/jn.1984.51.2.375

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

375-86

issue

2

eissn

0022-3077

issn

1522-1598

journal_volume

51

pub_type

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