Abstract:
:The effect of L-glutamate on muscle fibers of the anterior aorta of the marine gastropod Aplysia are characterized. Iontophoretically applied L-glutamate depolarized anterior aorta muscle fibers in 14% of the applications; no response was detected in the other applications. Responses to iontophoretically applied L-glutamate desensitize rapidly and are antagonized by 2-amino-4-phosphonobutyric acid (2-APB). 2-APB also blocked excitatory junctional potentials (EJPs) in the anterior aorta. No significant response to D-glutamate was observed. These characteristics match those of L-glutamate at the arthropod neuromuscular junction. Bath-applied L-glutamate also depolarizes anterior aorta muscle fibers, by a mechanism clearly different from that of iontophoretically applied L-glutamate. Present results make L-glutamate a candidate neurotransmitter to molluscan circulatory muscles.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Sawada M,Gibson D,McAdoo DJdoi
10.1152/jn.1984.51.2.375subject
Has Abstractpub_date
1984-02-01 00:00:00pages
375-86issue
2eissn
0022-3077issn
1522-1598journal_volume
51pub_type
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