Abstract:
:The goal of retinal prosthetic devices is to generate meaningful visual information in patients that have lost outer retinal function. To accomplish this, these devices should generate patterns of ganglion cell activity that closely resemble the spatial and temporal components of those patterns that are normally elicited by light. Here, we developed a stimulus paradigm that generates precise temporal patterns of activity in retinal ganglion cells, including those patterns normally generated by light. Electrical stimulus pulses (> or =1-ms duration) elicited activity in neurons distal to the ganglion cells; this resulted in ganglion cell spiking that could last as long as 100 ms. However, short pulses, <0.15 ms, elicited only a single spike within 0.7 ms of the leading edge of the pulse. Trains of these short pulses elicited one spike per pulse at frequencies < or =250 Hz. Patterns of short electrical pulses (derived from normal light elicited spike patterns) were delivered to ganglion cells and generated spike patterns that replicated the normal light patterns. Finally, we found that one spike per pulse was elicited over almost a 2.5:1 range of stimulus amplitudes. Thus a common stimulus amplitude could accommodate a 2.5:1 range of activation thresholds, e.g., caused by differences arising from cell biophysical properties or from variations in electrode-to-cell distance arising when a multielectrode array is placed on the retina. This stimulus paradigm can generate the temporal resolution required for a prosthetic device.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Fried SI,Hsueh HA,Werblin FSdoi
10.1152/jn.00849.2005subject
Has Abstractpub_date
2006-02-01 00:00:00pages
970-8issue
2eissn
0022-3077issn
1522-1598pii
00849.2005journal_volume
95pub_type
杂志文章abstract::1. The pteropod mollusk Clione limacina swims by rhythmical oscillations of two wings, and its spatial orientation during locomotion is determined by tail movements. The majority of neurons responsible for generation of the wing and tail movements are located in the pedal ganglia. On the other hand, the majority of se...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.5.1912
更新日期:1995-05-01 00:00:00
abstract::1. In chronically prepared, freely moving rats, electrical stimulation was applied to the angular bundle, and responses were recorded extracellularly at a variety of sites in the ipsilateral hippocampal formation. At each recording site the stimulus-response relationship was tested during four different behavioral sta...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1978.41.3.716
更新日期:1978-05-01 00:00:00
abstract::Humans quickly and sophisticatedly correct their movements in response to changes in the world, such as when reaching to a target that abruptly changes its location. The vigor of these movement corrections is time-dependent, increasing if the time left to make the correction decreases, which can be explained by optima...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00616.2018
更新日期:2019-09-01 00:00:00
abstract::Rod signals traverse several synapses en route to cone bipolar cells. In one pathway, rods communicate directly with cones via gap junctions. In a second pathway, signals flow rods-rod bipolars-AII amacrines-cone bipolars. The relative contribution of each pathway to retinal function is not well understood. Here we ha...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00597.2004
更新日期:2005-03-01 00:00:00
abstract::The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparations provide an unparalleled opportunity to observe and control neural circuits. To investigate how neural circuits produce behavior, these m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00669.2012
更新日期:2012-12-01 00:00:00
abstract::1. This paper examines the electrophysiological properties of cultured rat adrenal chromaffin cells at different stages of neuron-like morphological differentiation in response to nerve growth factor (NGF). 2. Chromaffin cells display a large variability in the morphological changes after exposure to NGF. However, a m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.4.1938
更新日期:1994-10-01 00:00:00
abstract::An inhibitory role for strychnine-sensitive glycine-gated chloride channels (GlyRs) in mature hippocampus is beginning to be appreciated. We have reported previously that CA1 pyramidal cells and GABAergic interneurons recorded in 3- to 4-wk-old rat hippocampal slices express functional GlyRs, dispelling previous misco...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00386.2005
更新日期:2006-04-01 00:00:00
abstract::The effect of peripheral lesions on cerebral somatosensory representations is well studied for experimentally induced amputations and deafferentations acquired later in life. However, few studies have investigated the brain's capacity for plastic changes in congenital malformations. We studied somatosensory-evoked fie...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00749.2004
更新日期:2005-02-01 00:00:00
abstract::Mutual inhibition between the GABAergic cells of the thalamic reticular nucleus (RTN) is important in regulating oscillations in the thalamocortical network, promoting those in the spindle range of frequencies over those at lower frequencies. Excitatory inputs to the RTN from the cerebral cortex are numerically large ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00624.2003
更新日期:2004-02-01 00:00:00
abstract::Subacute and chronic changes in tonic GABAergic inhibition occur in human and experimental epilepsy. Less is known about how tonic inhibition is modulated over shorter time frames (seconds). We measured endogenous tonic GABA currents from cultured rat hippocampal neurons to evaluate how they are affected by 1) transie...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00460.2012
更新日期:2013-02-01 00:00:00
abstract::Frequent gait modifications are often required to navigate our world. These can involve long or wide steps or changes in direction. People generally prefer to minimize the motor cost (or effort) of a movement, although with changes in gait this is not always possible. The decision of when and where to shift gaze is cr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00027.2019
更新日期:2019-07-01 00:00:00
abstract::1. Single-unit activity was recorded from 215 neurons in the medial bulbar reticular formation during the masticatory sequence, from intake to deglutition, of 3 kinds of food (cat food pellets, canned fish, and milk) in 8 chronically prepared, unanesthetized, spontaneously respiring cats with their head fixed to a ste...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.4.1333
更新日期:1988-10-01 00:00:00
abstract::1. Electrical stimulation applied within the dorsolateral funiculus of the spinal cord of an intact, unanesthetized turtle can elicit rhythmic limb movements similar to those observed during swimming. 2. A spontaneous display of hindlimb swimming movements is not observed in adult turtles whose spinal cord is transect...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1977.40.4.768
更新日期:1977-07-01 00:00:00
abstract::Nervous systems are thought to encode information as patterns of electrical activity distributed sparsely through networks of neurons. These networks then process information by transforming one pattern of electrical activity into another. To store information as a pattern, a neural network must strengthen synapses be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00533.2013
更新日期:2013-12-01 00:00:00
abstract::The transient potassium current (I(A)) plays an important role in shaping the firing properties of pyloric neurons in the stomatogastric ganglion (STG) of the spiny lobster, Panulirus interruptus. The shal gene encodes I(A) in pyloric neurons. However, when we over-expressed the lobster Shal protein by shal RNA inject...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00837.2002
更新日期:2003-04-01 00:00:00
abstract::It is an essential feature for the visual system to keep track of self-motion to maintain space constancy. Therefore the saccadic system uses extraretinal information about previous saccades to update the internal representation of memorized targets, an ability that has been identified in behavioral and electrophysiol...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00543.2004
更新日期:2005-03-01 00:00:00
abstract::Frequency facilitation is a process whereby neurosecretion increases as a function of stimulation frequency during repetitive synaptic activity. To examine the physiological basis underlying facilitation, we have estimated the frequency dependence of the synaptic parameters n (number of units capable of responding to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.1.417
更新日期:1997-07-01 00:00:00
abstract::We recorded local field potentials (LFPs) and single-unit activity simultaneously in the macaque primary visual cortex (V1) and studied their responses to drifting sinusoidal gratings that were chosen to be "optimal" for the single units. Over all stimulus conditions, the LFP spectra have much greater power in the low...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00919.2004
更新日期:2005-07-01 00:00:00
abstract::Extraretinal information, such as corollary discharge (CD), is hypothesized to help compensate for saccade-induced visual input disruptions. However, support for this hypothesis is largely for one-dimensional transsaccadic visual changes, with little comprehensive information on the spatial characteristics. Here we sy...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00657.2015
更新日期:2016-03-01 00:00:00
abstract::Prominent arginine-vasopressin (AVP) binding and AVP V(1) type receptors are expressed early in the developing rat spinal cord. We sought to characterize their influence on neural excitability by using patch-clamp techniques to record AVP-induced responses from a population of motoneurons and interneurons in neonatal ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.3.1202
更新日期:2001-09-01 00:00:00
abstract::1. We recorded single cell activities in the caudate nucleus of the monkeys trained to perform a series of visuomotor tasks. In the first part of this paper, we summarize the types and locations of neurons in the monkey caudate nucleus. In the second part, we report the characteristics of neurons related to saccadic e...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.61.4.780
更新日期:1989-04-01 00:00:00
abstract::1. Membrane currents of normal and TEA-injected cat lumbar motoneurons were investigated using the technique of somatic voltage clamp. 2. The current-voltage (I-V) relation of healthy motoneurons contains a region of negative slope conductance caused by a persistent inward current component (Ii). In the most striking ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1980.43.6.1700
更新日期:1980-06-01 00:00:00
abstract::Membrane retrieval following exocytosis in synaptic terminals is fast and compensatory, however, little is known about the factors that regulate or contribute to this special form of endocytosis. We used whole-terminal capacitance measurements to examine the effect of hydrostatic pressure on compensatory endocytosis i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00267.2002
更新日期:2002-11-01 00:00:00
abstract::The goal of this study was to characterize the dynamics and functional connectivity of brain networks associated with fast (short-term) learning of handwriting using functional magnetic resonance imaging. Participants (n = 12) performed a graphomotor sequence learning task (naïve subjects learning to draw simple, 3-st...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00449.2009
更新日期:2010-06-01 00:00:00
abstract::Microsleeps are brief episodes of arousal level decrease manifested through behavioral signs. Brain activity during microsleep in the presence of external stimulus remains poorly understood. In this study, we sought to understand neural responses to auditory stimulation during microsleep. We gave participants the simp...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00825.2018
更新日期:2019-12-01 00:00:00
abstract::The effect of stimulation of the laterodorsal tegmental nucleus (LDT) on the activity of single neurons in the dorsal lateral geniculate nucleus was studied in rats anesthetized with urethan. The LDT is the largest aggregation of cholinergic neurons in the brain stem that project to the thalamus, and in the rat is suf...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.56.5.1297
更新日期:1986-11-01 00:00:00
abstract::The brain stem nucleus locus coeruleus (LC) is thought to modulate cortical excitability by norepinephrine (NE) release in LC forebrain targets. The effects of LC burst discharge, typically evoked by a strong excitatory input, on cortical ongoing activity are poorly understood. To address this question, we combined di...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00920.2013
更新日期:2014-06-15 00:00:00
abstract::1. We studied the organization of motor units in the tenuissimus (TEN) muscle of pentobarbital-anesthetized cats. The cat TEN is a long, delicate straplike muscle that spans hip and knee, which has a very flat length-tension curve through 22 mm of length change. 2. The TEN motor nucleus, labeled by retrograde transpor...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.59.4.1128
更新日期:1988-04-01 00:00:00
abstract::The responses of spinothalamic tract neurons were studied by extra- and intracellular recordings from the lumbosacral spinal cord in anesthetized rhesus monkeys (Macaca mulatta). The neurons were identified by antidromic activation from the contralateral diencephalon. They were then classified by the mildest form of m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.1.132
更新日期:1975-01-01 00:00:00
abstract::The mechanisms and impact of correlated, or synchronous, firing among pairs and groups of neurons are under intense investigation throughout the nervous system. A ubiquitous circuit feature that can give rise to such correlations consists of overlapping, or common, inputs to pairs and populations of cells, leading to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00928.2011
更新日期:2012-09-01 00:00:00