Shrinkage of somatosensory hand area in subjects with upper extremity dysmelia revealed by magnetoencephalography.

Abstract:

:The effect of peripheral lesions on cerebral somatosensory representations is well studied for experimentally induced amputations and deafferentations acquired later in life. However, few studies have investigated the brain's capacity for plastic changes in congenital malformations. We studied somatosensory-evoked fields to electrical stimulation of the bordering fingers in 10 subjects with upper extremity dysmelia in comparison with 10 control subjects using a 122-channel whole-head magnetometer. The number of developed fingers varied between two and four in the affected subjects. We localized finger representations in the primary somatosensory cortex and calculated Euclidian distances to estimate the size of the somatosensory hand area. Euclidian distances were significantly smaller in dysmelic subjects (5.7 mm) than in control subjects (11.6 mm) and were related to the number of the developed fingers on the contralateral hand. In contrast, individual finger representations were not found to be reduced. We suggest that the shrinkage of the somatosensory hand area might be related to the congenital nature of the malformation, to the smaller anatomical hand size in the affected subjects, and/or to use-dependent effects due to impaired hand function.

journal_name

J Neurophysiol

authors

Stoeckel MC,Pollok B,Witte OW,Seitz RJ,Schnitzler A

doi

10.1152/jn.00749.2004

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

813-8

issue

2

eissn

0022-3077

issn

1522-1598

pii

00749.2004

journal_volume

93

pub_type

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