Risky business: disambiguating ambiguity-related responses in the brain.

abstract：:1. Mouse hippocampal neurons in dissociated culture were grown at low density on previously plated hippocampal glial cell cultures and voltage clamped using the tight seal whole-cell patch-clamp technique. Flow pipes were used to rapidly exchange the extracellular solution, and to apply N-methyl-D-aspartic acid (NMDA)...

journal_title：Journal of neurophysiology

authors： Mayer ML,Westbrook GL,Vyklický L Jr

更新日期：1988-08-01 00:00:00

abstract：:AMPA-type glutamate receptors are normally Ca(2+) impermeable due to the expression of the GluR2 receptor subunit. By using GluR2 null mice we were able to detect miniature synaptic Ca(2+) transients (MSCTs) associated with AMPA-type receptor-mediated miniature synaptic currents at single synapses in primary cortical ...

journal_title：Journal of neurophysiology

authors： Wang S,Jia Z,Roder J,Murphy TH

更新日期：2002-07-01 00:00:00

abstract：:Whole cell and cell-attached patch-clamp techniques characterized the neurosteroid anesthetic alphaxalone's (5alpha-pregnane-3alpha-ol-11,20-dione) effects on GABAA receptors and on Cl- currents in cultured embryonic (5- to 8-wk old) human dorsal root ganglion neurons. Alphaxalone applied by pressure pulses from close...

journal_title：Journal of neurophysiology

authors： Valeyev AY,Hackman JC,Holohean AM,Wood PM,Katz JL,Davidoff RA

更新日期：1999-07-01 00:00:00

abstract：:Seizures may cause brain damage due to mechanisms initiated by excessive excitatory synaptic transmission. One such mechanism is the activation of death-promoting intracellular cascades by the influx and the perturbed homeostasis of Ca2+. The neuroprotective effects of preventing the entry of Ca2+ from voltage-depende...

journal_title：Journal of neurophysiology

authors： Pelletier MR,Wadia JS,Mills LR,Carlen PL

更新日期：1999-06-01 00:00:00

abstract：:The pacemaker current of a bursting neuron of Helix pomatia was investigated using voltage-clamp and pressure-injection techniques. In the steady state the net membrane current was zero near threshold of the action potential at -45 mV. Negative to this potential the membrane current was inward and steady. During burst...

journal_title：Journal of neurophysiology

authors： Swandulla D,Lux HD

更新日期：1985-12-01 00:00:00

abstract：:Muscle spindles provide exquisitely sensitive proprioceptive information regarding joint position and movement. Through passively driven length changes in the muscle-tendon unit (MTU), muscle spindles detect joint rotations because of their in-parallel mechanical linkage to muscle fascicles. In human microneurography ...

journal_title：Journal of neurophysiology

authors： Day J,Bent LR,Birznieks I,Macefield VG,Cresswell AG

更新日期：2017-04-01 00:00:00

abstract：:1. A quantitative analysis of facilitation during the kindling stimulation to the amygdala was conducted by measuring the area between the excitatory potential and the baseline in the averaged tetanic response recorded at the entorhinal cortex. The changes in facilitation were then compared with the development of ele...

journal_title：Journal of neurophysiology

authors： Matsuura S,Hirayama K,Murata R

更新日期：1993-08-01 00:00:00

abstract：:During seizure-like events (SLEs), intracellular Ca2+ concentration ([Ca2+]i) increases causing depolarization of the mitochondrial membrane and subsequent intramitochondrial accumulation of Ca2+. Mitochondrial depolarization results in an interruption of oxidative phosphorylation and increase in reactive oxygen speci...

journal_title：Journal of neurophysiology

authors： Schuchmann S,Buchheim K,Meierkord H,Heinemann U

更新日期：1999-01-01 00:00:00

abstract：:Several previous studies have shown the existence of Up and Down states and have linked their magnitude (e.g., depolarization level) to the size of sensory-evoked responses. Here, we studied how the temporal dynamics of such states influence the sensory-evoked response to vibrissa deflection. Under alpha-chloralose an...

journal_title：Journal of neurophysiology

authors： Haslinger R,Ulbert I,Moore CI,Brown EN,Devor A

更新日期：2006-09-01 00:00:00

abstract：:The discovery that neuroligin is a key protein involved in synapse formation offers the unprecedented opportunity to induce functional synapses between neurons and heterologous cells. We took this opportunity recording for the first-time synaptic currents in human embryonic kidney 293 (HEK293) cells transfected with n...

journal_title：Journal of neurophysiology

authors： Fu Z,Washbourne P,Ortinski P,Vicini S

更新日期：2003-12-01 00:00:00

abstract：:While it has been well established that optostatic and optokinetic cues contribute to the perception of vertical, it is unclear how the brain processes their combined presence with the nonvisual vestibular cues. Using a psychometric approach, we examined the percept of vertical in human participants (n = 17) with thei...

journal_title：Journal of neurophysiology

authors： Niehof N,Perdreau F,Koppen M,Medendorp WP

更新日期：2019-08-01 00:00:00

abstract：:We studied the properties of voltage-activated outward currents in two types of spider cuticular mechanoreceptor neurons to learn if these currents contribute to the differences in their adaptation properties. Both types of neurons adapt rapidly to sustained stimuli, but type A neurons usually only fire one or two act...

journal_title：Journal of neurophysiology

authors： Sekizawa SI,French AS,Höger U,Torkkeli PH

更新日期：1999-06-01 00:00:00

abstract：:The operculoinsular cortical region has a major role in the representation of noxious stimuli, based on functional imaging observations, clinical lesion studies, and EEG recordings of specifically pain-related laser-evoked potentials (LEPs) in humans. The source of LEPs has not been identified, and several somatic rep...

journal_title：Journal of neurophysiology

authors： Baumgärtner U,Tiede W,Treede RD,Craig AD

更新日期：2006-11-01 00:00:00

abstract：:1. Extracellular bath application of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-62 to hippocampal slices in vitro blocked the induction of long-term depression (LTD) by low-frequency Schaffer collateral stimulation (1 Hz/15 min) of the same concentration as has been shown previously to pre...

journal_title：Journal of neurophysiology

authors： Stanton PK,Gage AT

更新日期：1996-09-01 00:00:00

abstract：:Long-term depression (LTD) was induced in neocortical layer 5 pyramidal connections by pairing presynaptic firing with subthreshold postsynaptic depolarization (dLTD) or via a spike-timing protocol (tLTD). Like tLTD, dLTD reduced short-term depression and increased the coefficient of variation consistent with a presyn...

journal_title：Journal of neurophysiology

authors： Sjöström PJ,Turrigiano GG,Nelson SB

更新日期：2004-12-01 00:00:00

abstract：:We investigated whether heptanol and other long-chain alcohols that are known to block gap junctions interfere with the generation or the propagation of spreading depression (SD). Waves of SD were triggered by micro-injection of concentrated KCl solution in stratum (s.) radiatum of CA1 of rat hippocampal tissue slices...

journal_title：Journal of neurophysiology

authors： Largo C,Tombaugh GC,Aitken PG,Herreras O,Somjen GG

更新日期：1997-01-01 00:00:00

abstract：:Inactivation permits direct assessment of the functional contribution of a given brain area to behavior. Previous inactivation studies of the frontal eye field (FEF) have either used large permanent ablations or reversible pharmacological techniques that only inactivate a small volume of tissue. Here we evaluated the ...

journal_title：Journal of neurophysiology

authors： Peel TR,Johnston K,Lomber SG,Corneil BD

更新日期：2014-01-01 00:00:00

abstract：:Neural activity was recorded in the parietooccipital cortex while monkeys performed different tasks aimed at investigating visuomotor interactions of retinal, eye, and arm-related signals on neural activity. The tasks were arm reaching 1) to foveated targets; 2) to extrafoveal targets, with constant eye position; 3) w...

journal_title：Journal of neurophysiology

authors： Battaglia-Mayer A,Ferraina S,Mitsuda T,Marconi B,Genovesio A,Onorati P,Lacquaniti F,Caminiti R

更新日期：2000-04-01 00:00:00

abstract：:1. High-voltage-activated Ca2+ currents [ICa(HVA)] were studied in immunolabeled mouse retinal ganglion neurons (RGNs) to elucidate channel-specific components and their developmental changes in vitro. 2. Neurons were dissociated at postnatal day 5. RGNs were selected for electrophysiological measurements by vital lab...

journal_title：Journal of neurophysiology

authors： Rothe T,Grantyn R

更新日期：1994-11-01 00:00:00

abstract：:The capabilities of any sensory system are ultimately constrained by the properties of the sensory neurons: the ability to detect and represent stimuli is limited by noise due to spontaneous activity, and optimal decoding in downstream circuitry must be matched to the nature of the encoding performed at the input. Her...

journal_title：Journal of neurophysiology

authors： Arnson HA,Holy TE

更新日期：2011-07-01 00:00:00

abstract：:1. Whole cell current-clamp recordings show that odors not only depolarize but may also hyperpolarize lobster olfactory receptor cells. Odor-evoked hyperpolarizations occurred in 36% of 178 receptor cells examined. Cell-attached recordings of action potentials followed by current-clamp recordings in the same cell indi...

journal_title：Journal of neurophysiology

authors： Michel WC,McClintock TS,Ache BW

更新日期：1991-03-01 00:00:00

abstract：:The turtle posterior crista consists of two hemicristae. Each hemicrista extends from the planum semilunatum to the nonsensory torus and includes a central zone (CZ) surrounded by a peripheral zone (PZ). Type I and type II hair cells are found in the CZ and are innervated by calyx, dimorphic and bouton afferents. Only...

journal_title：Journal of neurophysiology

authors： Brichta AM,Goldberg JM

更新日期：2000-03-01 00:00:00

abstract：:Fragile X syndrome is produced by a defect in a single X-linked gene, called Fmr1, and is characterized by abnormal dendritic spine morphologies with spines that are longer and thinner in neocortex than those from age-matched controls. Studies using Fmr1 knockout mice indicate that spine abnormalities are especially p...

journal_title：Journal of neurophysiology

authors： Desai NS,Casimiro TM,Gruber SM,Vanderklish PW

更新日期：2006-10-01 00:00:00

abstract：:In this article, we review a recent paper by Stevenson et al. (J Neurosci 34: 691-697, 2014). This paper illustrates the need to present different forms of stimuli in order to characterize the perceptual abilities of people with autism spectrum disorder (ASD). Furthermore, we will discuss their behavioral results and ...

journal_title：Journal of neurophysiology

authors： Chan JS,Naumer MJ

更新日期：2014-12-01 00:00:00

abstract：:The role of voltage-dependent calcium channels (VDCCs) in the nicotinic acetylcholine receptor (nAChR)-mediated enhancement of spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) was investigated in chick brain slices. Whole cell recordings of neurons in the lateral spiriform (SpL) and ventral lateral genic...

journal_title：Journal of neurophysiology

authors： Tredway TL,Guo JZ,Chiappinelli VA

更新日期：1999-02-01 00:00:00

abstract：:1. This paper examines the electrophysiological properties of cultured rat adrenal chromaffin cells at different stages of neuron-like morphological differentiation in response to nerve growth factor (NGF). 2. Chromaffin cells display a large variability in the morphological changes after exposure to NGF. However, a m...

journal_title：Journal of neurophysiology

authors： Islas-Suárez L,Gómez-Chavarín M,Drucker-Colín R,Hernández-Cruz A

更新日期：1994-10-01 00:00:00

abstract：:1. The properties of parietal neurons were studied in four adult rhesus monkeys during fast arm movements. The animals were trained to perform flexion or extension of the forearm about the elbow in response to specific auditory cues. Single neuron activity was recorded in 272 area 5 neurons, 81 neurons of the somatose...

journal_title：Journal of neurophysiology

authors： Burbaud P,Doegle C,Gross C,Bioulac B

更新日期：1991-08-01 00:00:00

abstract：:We examined the contribution of the motor cortex to the control of intralimb coordination during reaching in the standing cat. We recorded the activity of 151 pyramidal tract neurons (PTNs) in the forelimb representation of three cats during a task in which the cat reached forward from a standing position to press a l...

journal_title：Journal of neurophysiology

authors： Yakovenko S,Krouchev N,Drew T

更新日期：2011-01-01 00:00:00

abstract：:Considerable evidence suggests that brain stem pedunculopontine tegmentum (PPT) cholinergic cells are critically involved in the normal regulation of wakefulness and rapid eye movement (REM) sleep. However, much of this evidence comes from indirect studies. Thus, although involvement of PPT cholinergic neurons has bee...

journal_title：Journal of neurophysiology

authors： Datta S,Siwek DF

更新日期：1997-06-01 00:00:00

abstract：:This study examined the influence of proprioceptive input from hip flexor muscles on the activity in hip flexors during the swing phase of walking in the decerebrate cat. One hindlimb was partially denervated to remove cutaneous input and afferent input from most other hindlimb muscles. Perturbations to hip movement w...

journal_title：Journal of neurophysiology

authors： Lam T,Pearson KG

更新日期：2001-09-01 00:00:00