The development of transmission at an identified molluscan synapse. II. A quantal analysis of transmission.

Abstract:

:1. A quantal analysis of transmission at the identified molluscan synapse, V2-RPr1, was performed during development. The study was intended to determine the pre- and postsynaptic contributions to the marked changes in transmitter release described in the previous report. 2. The success of the quantal analysis was predicated on overcoming the problems associated with extending the quantal analysis technique to central synapses. This involved adopting the following strategies: 1) using a low-noise recording system coupled with electrical filtering; 2) establishing objective criteria for failures recognition; and 3) using three methods to determine the quantal content: amplitude histograms, failures analysis, and the coefficient of variation. 3. The correlation of the results obtained from an analysis of amplitude histograms and from failures analysis were highly significant (P less than 0.01) at all times studied. A similar significant correlation was observed between the failures method and the coefficient of variation methods. 4. The amplitude of the quantal unit declined progressively during development (range: 131-25 microV), in parallel with the decrease in the postsynaptic input resistance (range: 103-5 M omega). 5. At both frequencies of stimulation (0.02 and 0.2 Hz), there is an approximately 20-fold increase in quantal content over the period of the study. Frequency facilitation at the synapse is due to an increase in quantal content. 6. Possible structural correlates for the developmental increase in quantal content were discussed.

journal_name

J Neurophysiol

authors

Pawson PA,Chase R

doi

10.1152/jn.1988.60.6.2211

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

2211-22

issue

6

eissn

0022-3077

issn

1522-1598

journal_volume

60

pub_type

杂志文章
  • Mechanisms for signal transformation in lemniscal auditory thalamus.

    abstract::1. During alertness, lemniscal thalamocortical neurons in the ventral medial geniculate body (MGBv) encode sound signals by firing action potentials in a tonic mode. When they are in a burst firing mode, characteristic of thalamic neurons during some sleep states, the same stimuli may have an alerting function, leadin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.6.3597

    authors: Tennigkeit F,Schwarz DW,Puil E

    更新日期:1996-12-01 00:00:00

  • The two-dimensional spatial structure of simple receptive fields in cat striate cortex.

    abstract::1. A reverse correlation (6, 8, 25, 35) method is developed that allows quantitative determination of visual receptive-field structure in two spatial dimensions. This method is applied to simple cells in the cat striate cortex. 2. It is demonstrated that the reverse correlation method yields results with several desir...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.6.1187

    authors: Jones JP,Palmer LA

    更新日期:1987-12-01 00:00:00

  • Activity of hindlimb motor units during locomotion in the conscious rat.

    abstract::This paper compares the activity of hindlimb motor units from muscles mainly composed of fast-twitch muscle fibers (medial and lateral gastrocnemius: MG/LG, tibialis anterior: TA) to motor units from a muscle mainly composed of slow-twitch muscle fibers (soleus: SOL) during unrestrained walking in the conscious rat. S...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2002

    authors: Gorassini M,Eken T,Bennett DJ,Kiehn O,Hultborn H

    更新日期:2000-04-01 00:00:00

  • An optimization principle for determining movement duration.

    abstract::Movement duration is an integral component of motor control, but nearly all extant optimization models of motor planning prefix duration instead of explaining it. Here we propose a new optimization principle that predicts movement duration. The model assumes that the brain attempts to minimize movement duration under ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00751.2005

    authors: Tanaka H,Krakauer JW,Qian N

    更新日期:2006-06-01 00:00:00

  • Sensitivity to temporal modulation rate and spectral bandwidth in the human auditory system: fMRI evidence.

    abstract::Hierarchical models of auditory processing often posit that optimal stimuli, i.e., those eliciting a maximal neural response, will increase in bandwidth and decrease in modulation rate as one ascends the auditory neuraxis. Here, we tested how bandwidth and modulation rate interact at several loci along the human centr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00308.2011

    authors: Overath T,Zhang Y,Sanes DH,Poeppel D

    更新日期:2012-04-01 00:00:00

  • Optimal delineation of single C-tactile and C-nociceptive afferents in humans by latency slowing.

    abstract::C-mechanoreceptors in humans comprise a population of unmyelinated afferents exhibiting a wide range of mechanical sensitivities. C-mechanoreceptors are putatively divided into those signaling gentle touch (C-tactile afferents, CTs) and nociception (C-mechanosensitive nociceptors, CMs), giving rise to positive and neg...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00939.2016

    authors: Watkins RH,Wessberg J,Backlund Wasling H,Dunham JP,Olausson H,Johnson RD,Ackerley R

    更新日期:2017-04-01 00:00:00

  • Decreased heart rate and enhanced sinus arrhythmia during interictal sleep demonstrate autonomic imbalance in generalized epilepsy.

    abstract::We hypothesized that epilepsy affects the activity of the autonomic nervous system even in the absence of seizures, which should manifest as differences in heart rate variability (HRV) and cardiac cycle. To test this hypothesis, we investigated ECG traces of 91 children and adolescents with generalized epilepsy and 25...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01120.2015

    authors: Sivakumar SS,Namath AG,Tuxhorn IE,Lewis SJ,Galán RF

    更新日期:2016-04-01 00:00:00

  • Integration of vestibular and head movement signals in the vestibular nuclei during whole-body rotation.

    abstract::Single-unit recordings were obtained from 107 horizontal semicircular canal-related central vestibular neurons in three alert squirrel monkeys during passive sinusoidal whole-body rotation (WBR) while the head was free to move in the yaw plane (2.3 Hz, 20 degrees /s). Most of the units were identified as secondary ves...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.1.436

    authors: Gdowski GT,McCrea RA

    更新日期:1999-07-01 00:00:00

  • Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons.

    abstract::Reports of cholecystokinin (CCK) binding and expression of CCK receptors in neonatal rodent spinal cord suggest that CCK may influence neuronal excitability. In patch-clamp recordings from 19/21 ventral horn motoneurons in neonatal (PN 5-12 days) rat spinal cord slices, we noted a slowly rising and prolonged membrane ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00148.2007

    authors: Oz M,Yang KH,Shippenberg TS,Renaud LP,O'Donovan MJ

    更新日期:2007-09-01 00:00:00

  • A unifying model of concurrent spatial and temporal modularity in muscle activity.

    abstract::Modularity in the central nervous system (CNS), i.e., the brain capability to generate a wide repertoire of movements by combining a small number of building blocks ("modules"), is thought to underlie the control of movement. Numerous studies reported evidence for such a modular organization by identifying invariant m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00245.2013

    authors: Delis I,Panzeri S,Pozzo T,Berret B

    更新日期:2014-02-01 00:00:00

  • PAD and PAH response patterns of group Ia- and Ib-fibers to cutaneous and descending inputs in the cat spinal cord.

    abstract::The characteristics of the primary afferent depolarization (PAD) of Ia- and Ib-fibers generated by segmental and descending inputs have been analyzed in the spinal cord of anesthetized cats. The PAD was inferred from the changes produced by conditioning inputs on the intraspinal stimulus current required to produce a ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.4.987

    authors: Rudomin P,Solodkin M,Jiménez I

    更新日期:1986-10-01 00:00:00

  • Functional properties of ryanodine receptors in hippocampal neurons change during early differentiation in culture.

    abstract::6-((4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl)amino)hexanoic acid ryanodine (BODIPY-ryanodine) binding and Ca(2+) imaging were used to study the properties of ryanodine receptors (RyRs) and cytoplasmic Ca(2+) (Ca) changes in neurons cultured from the embryonic rat hippocampus during the earli...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.3.1077

    authors: Sukhareva M,Smith SV,Maric D,Barker JL

    更新日期:2002-09-01 00:00:00

  • Heterogeneity of voltage- and chemosignal-activated response profiles in vomeronasal sensory neurons.

    abstract::Liolaemus lizards were explored to ascertain whether they would make an amenable model to study single-cell electrophysiology of neurons in the vomeronasal organ (VNO). Despite a rich array of chemosensory-related behaviors chronicled for this genus, no anatomical or functional data exist for the VNO, the organ mediat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00490.2005

    authors: Labra A,Brann JH,Fadool DA

    更新日期:2005-10-01 00:00:00

  • Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex.

    abstract::Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key functional microcircuits within layer 2/3 of mouse primary...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00917.2011

    authors: Avermann M,Tomm C,Mateo C,Gerstner W,Petersen CC

    更新日期:2012-06-01 00:00:00

  • Homomeric and heteromeric ion channels formed from the kainate-type subunits GluR6 and KA2 have very small, but different, unitary conductances.

    abstract::1. Patch-clamp methods were used to study recombinant glutamate receptor (GluR) ion channels expressed in human embryonic kidney cells (HEK 293) after transfection of the cells with cDNAs encoding kainate (KA)-type GluR subunits. Cells were transiently or stably transfected with the fully edited (R) version of GluR6 o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.1.510

    authors: Howe JR

    更新日期:1996-07-01 00:00:00

  • An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex.

    abstract::EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00263.2005

    authors: Lakatos P,Shah AS,Knuth KH,Ulbert I,Karmos G,Schroeder CE

    更新日期:2005-09-01 00:00:00

  • On the origin of event-related potentials indexing covert attentional selection during visual search: timing of selection by macaque frontal eye field and event-related potentials during pop-out search.

    abstract::Event-related potentials (ERPs) have provided crucial data concerning the time course of psychological processes, but the neural mechanisms producing ERP components remain poorly understood. This study continues a program of research in which we investigated the neural basis of attention-related ERP components by simu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00549.2012

    authors: Purcell BA,Schall JD,Woodman GF

    更新日期:2013-01-01 00:00:00

  • Entrainment of visual steady-state responses is modulated by global spatial statistics.

    abstract::The rhythmic delivery of visual stimuli evokes large-scale neuronal entrainment in the form of steady-state oscillatory field potentials. The spatiotemporal properties of stimulus drive appear to constrain the relative degrees of neuronal entrainment. Specific frequency ranges, for example, are uniquely suited for enh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00129.2017

    authors: Nguyen T,Kuntzelman K,Miskovic V

    更新日期:2017-07-01 00:00:00

  • Neural heterogeneity and efficient population codes for communication signals.

    abstract::Efficient sensory coding implies that populations of neurons should represent information-rich aspects of a signal with little redundancy. Recent studies have shown that neural heterogeneity in higher brain areas enhances the efficiency of encoding by reducing redundancy across the population. Here, we study how neura...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00256.2010

    authors: Marsat G,Maler L

    更新日期:2010-11-01 00:00:00

  • Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem.

    abstract::Cardiovascular function is regulated by a dynamic balance composed of sympathetic and parasympathetic activity. Sympathoexcitatory presympathetic neurons (PSNs) in the rostral ventrolateral medulla project directly to cardiac and vasomotor sympathetic preganglionic neurons in the spinal cord. In proximity to the PSNs ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01054.2012

    authors: Dergacheva O,Boychuk CR,Mendelowitz D

    更新日期:2013-08-01 00:00:00

  • Forcing of coupled nonlinear oscillators: studies of intersegmental coordination in the lamprey locomotor central pattern generator.

    abstract::1. This paper reports the results of an investigation of the basic mechanisms underlying intersegmental coordination in lamprey locomotion, by the use of a combined mathematical and biological approach. 2. Mathematically, the lamprey central pattern generator (CPG) is described as a chain of coupled nonlinear oscillat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.64.3.862

    authors: Williams TL,Sigvardt KA,Kopell N,Ermentrout GB,Remler MP

    更新日期:1990-09-01 00:00:00

  • Statistical context shapes stimulus-specific adaptation in human auditory cortex.

    abstract::Stimulus-specific adaptation is the phenomenon whereby neural response magnitude decreases with repeated stimulation. Inconsistencies between recent nonhuman animal recordings and computational modeling suggest dynamic influences on stimulus-specific adaptation. The present human electroencephalography (EEG) study inv...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00634.2014

    authors: Herrmann B,Henry MJ,Fromboluti EK,McAuley JD,Obleser J

    更新日期:2015-04-01 00:00:00

  • GABA-receptor-independent dorsal root afferents depolarization in the neonatal rat spinal cord.

    abstract::Dorsal root afferent depolarization and antidromic firing were studied in isolated spinal cords of neonatal rats. Spontaneous firing accompanied by occasional bursts could be recorded from most dorsal roots in the majority of the cords. The afferent bursts were enhanced after elevation of the extracellular potassium c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.5.2581

    authors: Kremer E,Lev-Tov A

    更新日期:1998-05-01 00:00:00

  • Correlated firing of cat retinal ganglion cells. I. Spontaneously active inputs to X- and Y-cells.

    abstract::1. The shared inputs to cat retinal ganglion cells have been investigated by studying correlations in the maintained firing of neighboring ganglion cells. The firing of one cell was recorded from its axon in the optic tract, while that of a neighboring cell was simultaneously recorded with a second electrode in the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.49.2.303

    authors: Mastronarde DN

    更新日期:1983-02-01 00:00:00

  • Afferent innervation patterns of the saccule in pigeons.

    abstract::The innervation patterns of vestibular saccular afferents were quantitatively investigated in pigeons using biotinylated dextran amine as a neural tracer and three-dimensional computer reconstruction. Type I hair cells were found throughout a large portion of the macula, with the highest density observed in the striol...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00817.2001

    authors: Zakir M,Huss D,Dickman JD

    更新日期:2003-01-01 00:00:00

  • Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis.

    abstract::The cardiac ganglion (CG) of Homarus americanus is a central pattern generator that consists of two oscillatory groups of neurons: "small cells" (SCs) and "large cells" (LCs). We have shown that SCs and LCs begin their bursts nearly simultaneously but end their bursts at variable phases. This variability contrasts wit...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01010.2012

    authors: Williams AH,Kwiatkowski MA,Mortimer AL,Marder E,Zeeman ML,Dickinson PS

    更新日期:2013-05-01 00:00:00

  • Kinematics of eye movements of cats to broadband acoustic targets.

    abstract::Operant conditioning was used to train cats with their heads immobilized to localize sound by directing their eyes to the location of the sources. The kinematics of those eye movements were studied and compared with eye movements to visual targets at the same locations. The main finding of this study is that eye movem...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.2.955

    authors: Populin LC,Yin TC

    更新日期:1999-08-01 00:00:00

  • The suppressive influence of moving textured backgrounds on responses of cat striate neurons to moving bars.

    abstract::The suppressive action of a moving textured background on responses to moving bars was investigated in 118 striate neurons, 19 dorsal lateral geniculate neurons, and 5 perigeniculate neurons in paralyzed and anesthetized cats. In standard conditions the background was a two-dimensional (2D) noise pattern, the bar move...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.6.1767

    authors: Gulyás B,Orban GA,Duysens J,Maes H

    更新日期:1987-06-01 00:00:00

  • Estimating use-dependent synaptic gain in autonomic ganglia by computational simulation and dynamic-clamp analysis.

    abstract::Biological gain mechanisms regulate the sensitivity and dynamics of signaling pathways at the systemic, cellular, and molecular levels. In the sympathetic nervous system, gain in sensory-motor feedback loops is essential for homeostatic regulation of blood pressure and body temperature. This study shows how synaptic c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00470.2004

    authors: Wheeler DW,Kullmann PH,Horn JP

    更新日期:2004-11-01 00:00:00

  • Analyzing octopus movements using three-dimensional reconstruction.

    abstract::Octopus arms, as well as other muscular hydrostats, are characterized by a very large number of degrees of freedom and a rich motion repertoire. Over the years, several attempts have been made to elucidate the interplay between the biomechanics of these organs and their control systems. Recent developments in electrop...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00739.2006

    authors: Yekutieli Y,Mitelman R,Hochner B,Flash T

    更新日期:2007-09-01 00:00:00