Abstract:
:Single-unit activity of the motor cortex (area 4gamma) was studied in cats performing reaching with the contra- versus ipsilateral forelimb. Reaching was initiated by a tone burst (Go cue), different limbs were used in separate blocks of trials. During reaching performed with the contralateral limb, three types of neurons were observed. The first type had biphasic pattern with an initial component locked to the Go cue followed by a component locked to the onset of reaching. The second type of neurons had monophasic discharges correlated both with the onset of the stimulus and with the movement. The third type showed responses related to the movement. Activity of the same cells investigated during reaching performed with the ipsilateral limb revealed that the cue-locked responses of the cells of the first type were effector independent, i.e., similar discharges locked to the Go cue were generated. The movement-related component of these cells was drastically reduced. The activity of some cells of the second type was suppressed during reaching with the ipsilateral limb. When performance was switched between limbs, a significant change of background discharge frequency was observed in 31% of the cells. The present results suggest that the sensory cue triggers elaboration of motor commands for reaching in both motor cortices, but further sensorimotor transformation is completed in only one hemisphere but is aborted actively in the other. It is also suggested that a certain pattern of background activity may serve a tuning function for elaboration of the command in the proper hemisphere.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Perfiliev Sdoi
10.1152/jn.00720.2003subject
Has Abstractpub_date
2005-05-01 00:00:00pages
2489-506issue
5eissn
0022-3077issn
1522-1598pii
00720.2003journal_volume
93pub_type
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