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Prenatal Exposure to PM2.5 and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort.

Abstract：

BACKGROUND:The autonomic nervous system plays a key role in maintaining homeostasis and responding to external stimuli. In adults, exposure to fine particulate matter ( PM 2.5 ) has been associated with reduced heart rate variability (HRV), an indicator of cardiac autonomic control. OBJECTIVES:Our goal was to investigate the associations of exposure to fine particulate matter ( PM 2.5 ) with HRV as an indicator of cardiac autonomic control during early development. METHODS:We studied 237 maternal-infant pairs in a Boston-based birth cohort. We estimated daily residential PM 2.5 using satellite data in combination with land-use regression predictors. In infants at 6 months of age, we measured parasympathetic nervous system (PNS) activity using continuous electrocardiogram monitoring during the Repeated Still-Face Paradigm, an experimental protocol designed to elicit autonomic reactivity in response to maternal interaction and disengagement. We used multivariable linear regression to examine average PM 2.5 exposure across pregnancy in relation to PNS withdrawal and activation, indexed by changes in respiration-corrected respiratory sinus arrhythmia ( RSA c )-an established metric of HRV that reflects cardiac vagal tone. We examined interactions with infant sex using cross-product terms. RESULTS:In adjusted models we found that a 1-unit increase in PM 2.5 (in micrograms per cubic meter) was associated with a 3.53% decrease in baseline RSA c (95% CI: - 6.96 , 0.02). In models examining RSA c change between episodes, higher PM 2.5 was generally associated with reduced PNS withdrawal during stress and reduced PNS activation during recovery; however, these associations were not statistically significant. We did not observe a significant interaction between PM 2.5 and sex. DISCUSSION:Prenatal exposure to PM 2.5 may disrupt cardiac vagal tone during infancy. Future research is needed to replicate these preliminary findings. https://doi.org/10.1289/EHP4434.

journal_name

Environ Health Perspect

journal_title

Environmental health perspectives

authors

Cowell WJ,Brunst KJ,Malin AJ,Coull BA,Gennings C,Kloog I,Lipton L,Wright RO,Enlow MB,Wright RJ

doi

10.1289/EHP4434

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

107007

issue

eissn

0091-6765

issn

1552-9924

journal_volume

127

pub_type

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Prenatal Exposure to PM2.5 and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort.