Abstract:
:Ensuring experimental outcomes are of the highest clinical caliber is crucial prior to the introduction of germline genome editing. However, if we are to police scientific progress using probability or the potential to go wrong, then we must account for the specious standards of human reproduction. With 15% of clinically recognized pregnancies estimated to end in spontaneous miscarriage within the first trimester, and 25% of all pregnancies ending in miscarriage, human reproduction has a high failure rate. These figures, coupled with the percentage of all births with congenital defects and the number of these who will die in the first year of life, paint two scenarios: one, that evolutionary checkpoints are cruel but critical, and two, that for the seemingly inevitable 3%, or 8 million babies born annually with congenital disorders, perhaps more must be done for prevention, when methods exist for prediction. Unifying progress in three coevolving technologies-assisted reproduction, genome editing, and genome sequencing-could produce revolutionary clinical changes in the harsh global statistics of hereditary disease. A historical perspective on the rocky foundations upon which IVF was built suggests that lessons should be learned from the misalignment of research and clinical practice due to funding and research restrictions. At present, it seems likely that history will repeat itself, and that progress in research will be hampered by hypocritical hesitation.
journal_name
Perspect Biol Medjournal_title
Perspectives in biology and medicineauthors
O'Neill HCdoi
10.1353/pbm.2020.0008subject
Has Abstractpub_date
2020-01-01 00:00:00pages
101-110issue
1eissn
0031-5982issn
1529-8795pii
S1529879520100085journal_volume
63pub_type
杂志文章abstract::The concept and determination of death by neurological or cardio-circulatory criteria play a crucial role for medical practice, society, and the law. Academic debates on death determination have regained momentum, and recent cases involving the neurological determination of death ("brain death") in the United States h...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2015.0036
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0006
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2007.0008
更新日期:2007-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2011.0013
更新日期:2011-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.1987.0051
更新日期:1987-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0021
更新日期:2013-04-01 00:00:00
abstract::Charles Dickens's adult life parallels the period when the movement for sanitary reform took root in England. Although he was not one of its leaders, he became in time one of its most outspoken advocates. This essay describes Dickens's growing involvement in the sanitary movement and looks at one of the most important...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2003.0025
更新日期:2003-04-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0025
更新日期:2019-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2016.0033
更新日期:2016-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.0.0045
更新日期:2008-10-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2004.0006
更新日期:2004-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0158
更新日期:2010-04-01 00:00:00