Abstract:
:We have previously demonstrated the radio-sensitizing effect of zoledronic acid (ZOL), a third generation bisphosphonate, on human esophageal squamous cell carcinoma (ESCC) cells. Here we show that ZOL suppresses metastatic progression of ESCC cells mainly through up-regulating the tight junction protein occludin. Exposure to ZOL at lower concentrations dramatically reduced migration and invasion of ESCC cells. In addition, ZOL treatment decreased the expression of mesenchymal markers, vimentin and N-cadherin, while increased the expression of the tight junction protein occludin. Moreover, ectopic expression of Slug, a well-known transcriptional repressor of occludin, partially but significantly abrogated the effect of ZOL on occludin expression and subsequently rescued the malignant metastatic phenotype, suggesting that Slug is one of the mediators underlying the anti-metastatic effect of ZOL. The present study is the first to report the significance of ZOL on ESCC metastasis. These data are promising for the future application of this drug regimen in patients with ESCC.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Lin C,Xin S,Qin X,Li H,Lin L,You Ydoi
10.1007/s10616-015-9884-7subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1233-41issue
4eissn
0920-9069issn
1573-0778pii
10.1007/s10616-015-9884-7journal_volume
68pub_type
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