Abstract:
:The Korean horse mussel extract was purified and fractionated by a bioassay-guided purification step. The final fraction contained seven steroid and one polycyclic aromatic compounds, in which cholest-7-en-3-ol, (3β,5α)- (58.7 %) was a main component followed by ergosta-7,22dien-3-ol (3β,5α,22E) (13.0 %). This extract exhibited strong anti-inflammatory activity determined solely through the nitric oxide inhibition assay in a dose-dependant manner with the IC50 value of 9.6 µg/mL and no cytotoxic effect on the macrophages. Moreover, it also exhibited strong cytotoxicity with the IC50 values of 21.4, 36.4, and 37.1 µg/mL against AGS, DLD-1, and HeLa cells, respectively. These results indicated that the horse mussel extract might be a functional ingredient in the prevention of inflammation and human cancers.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Wikarta JM,Kim SMdoi
10.1007/s10616-014-9840-ysubject
Has Abstractpub_date
2016-08-01 00:00:00pages
879-90issue
4eissn
0920-9069issn
1573-0778pii
10.1007/s10616-014-9840-yjournal_volume
68pub_type
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