Abstract：
:Aluminum promotes osteoblast (OB) apoptosis. Apoptosis is induced by the disordered calcium homeostasis. Therefore, to investigate the relationship between Al-induced OB apoptosis and calcium homeostasis, calvarium OBs from neonatal rats (3-4 days) were cultured and exposed to 0.048-mg/mL Al(3+) or 0.048-mg/mL Al(3+) combined with 5 μM BAPTA-AM (OBs were pretreated with 5 μM BAPTA-AM for 1 h, then added 0.048 mg/mL Al(3+)), respectively. Then OB apoptosis rate, intracellular calcium ions concentration ([Ca(2+)]i), mRNA expression level of calmodulin (CaM), and protein expression levels of CaM and p-CaMKII in OBs were examined. The result showed that AlCl3 increased OB apoptosis rate, and [Ca(2+)]i and p-CaMKII expression levels and decreased CaM expression levels, whereas BAPTA-AM relieved the effects. These results proved that AlCl3 induced OB apoptosis by disrupting the intracellular Ca(2+) homeostasis and activating the Ca(2+)/CaMKII signal pathway. Our findings can provide new insights for revealing the apoptosis mechanism of OBs exposed to AlCl3.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Cao Z,Liu D,Zhang Q,Sun X,Li Ydoi
10.1007/s12011-015-0417-1subject
Has Abstractpub_date
2016-02-01 00:00:00pages
247-53issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-015-0417-1journal_volume
169pub_type
杂志文章abstract：CONTEXT:Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy hav...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:94:2:97
更新日期：2003-08-01 00:00:00
abstract：:The present study aimed to investigate the prevalence of thrombocytopenia and its association with serum magnesium in a nationally representative cohort. A total of 8478 participants aged 18 years and over were recruited in a cross-sectional survey. Thrombocytopenia was defined as platelet count less than 150 × 10(9)/...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0406-4
更新日期：2016-01-01 00:00:00
abstract：:Iron-deficiency anemia (IDA) is the most common nutritional deficiency in childhood throughout the world. Although it has been shown that IRA is associated with elevated plasma copper and depleted zinc levels in children, there are conflicting results on the effect of iron supplementation on the absorption of these el...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1385/BTER:94:1:79
更新日期：2003-07-01 00:00:00
abstract：:In the present study, 15 different commercial tea brands sold in Khyber Pakhtunkhwa were collected from the markets. The samples were analyzed for the concentrations of ten selected heavy metals. The metal concentration showed a random distribution in all samples. The mean concentration of Cd, Cu, Mn, Pb, Zn, and Fe w...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02059-1
更新日期：2020-11-01 00:00:00
abstract：:Although substantial progress has been achieved in inductovely coupled plasma (ICP) spectroscopy, placing it among the principal spectroscopic tools in analytical chemistry research and applications laboratories, some limitations exist especially for the analysis of ultratrace concentration levels in biological materi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02918324
更新日期：1984-02-01 00:00:00
abstract：:This study has analyzed the role of several serum constituents, that have been proposed to effect the following reactionin situ: {fx1-1} {fx1-2} These reactions were monitored by measuring the rate of Fe(II) oxidation in the presence of apo-transferrin (reaction A) and Fe(III)-transferrin formation (reaction B) at 465...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789129
更新日期：1982-03-01 00:00:00
abstract：:The variance of testing was compared between the College of American Pathologists clinical survey and that of a recent review about hair mineral testing. The review suggested that the accuracy of hair mineral testing was unreliable. In general, there was a greater range of variance in the College of American Pathologi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:87:1-3:001
更新日期：2002-07-01 00:00:00
abstract：:Manganese (Mn) pollution is an important environmental problem because of the potential toxicity to human and animal health. However, the effects of Mn on energy metabolism and autophagy are not clear. Consequently, we examined the effects of excessive and chronic exposure to Mn on liver function, oxidative stress, re...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01960-8
更新日期：2020-09-01 00:00:00
abstract：:Differences in mineral nutrient composition of soils have been considered to affect health and population characteristics of free-ranging animals, particularly herbivores. Contents of Ca, Mg, and K in hair of female fawn white-tailed deer (Odocoileus virginianus) were measured for eight consecutive years to determine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783968
更新日期：1998-06-01 00:00:00
abstract：:We examined how the influence of smoking on blood and urinary cadmium (Cd) concentrations was modified by the level of environmental Cd. We measured blood and urinary Cd concentrations of 1134 men over 50 yr of age in three areas in Japan that were exposed to different levels of environmental Cd. Analysis of variance ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:110:2:107
更新日期：2006-05-01 00:00:00
abstract：:Methylmercury (MeHg) is highly toxic, and its principal target tissue in human is the nervous system, which has made MeHg intoxication a public health concern for many decades. Portulaca oleraceae (purslane), a member of the Portulacaceae family, is widespread as a weed and has been ranked the eighth most common plant...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0546-6
更新日期：2016-07-01 00:00:00
abstract：:Concentrations of selected metals (Cu, Mn, Zn, Cd) in tea leaves were investigated. Samples included black, green, and other (red, white, yellow, and oolong) teas. They were purchased on a local market but they covered different countries of origin. Beverages like yerba mate, rooibos, and fruit teas were also included...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1140-x
更新日期：2018-06-01 00:00:00
abstract：:Two experiments were performed to confirm that boron interacts with calcium, and that this interaction can be modified by dietary magnesium and potassium in the rat. Upon manipulating the dietary variables listed above, it was found that under certain conditions, boron and calcium deprivation similarly affected severa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783768
更新日期：1992-12-01 00:00:00
abstract：:Our previous studies showed that serum calcium level may have influence in the blood pressure to older male subjects, but the relationship between serum calcium level and blood lipids is unclear. The aim of this study was to evaluate the relationship between total serum calcium level and blood lipids. In our study, to...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9895-9
更新日期：2014-03-01 00:00:00
abstract：:Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01661-2
更新日期：2019-12-01 00:00:00
abstract：:Studies were designed to characterize the plasma membrane polypeptide composition of normal rat kidney (NRK) and virus-transformed NRK cells as a function of time following iron deprivation. Using this approach we found that rapid depletion of iron from the cells increases the amounts of two membrane-associated glycop...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02821711
更新日期：1979-06-01 00:00:00
abstract：:Exposure of people and animals to arsenic (As) is a global public health concern because As is widely distributed and associated with numerous adverse effects. As is a poisonous metalloid and arsenic trioxide (As2O3) is a form of As. Thus far, there have been very few reports on the inflammatory factor alterations of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0305-8
更新日期：2015-10-01 00:00:00
abstract：:Aspergillus terreus was cultivated on Harrold's medium supplemented with 0.1% (w/v) cadmium chloride as well as on sulfur free medium amended with 0.1% (w/v) sodium selenite and potassium tellurite separately. The cell free extract of the fungus for each treatment was fractionated on a column packed with Sephadex G 75...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990464
更新日期：1991-03-01 00:00:00
abstract：:Selenium selenate was administered to streptozotocin-induced diabetic rats to assess its effects on the detrusor muscle. Thirty-two rats were divided into four groups of eight subjects each. The study animals were made diabetic by means of a single intravenous injection of streptozotocin (STZ). The responsiveness of t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:93:1-3:171
更新日期：2003-07-01 00:00:00
abstract：:Since chromium(VI) is unreactive toward DNA under physiological conditions in vitro, the ability of carcinogenic chromium(VI) compounds to damage DNA depends on the presence of cellular redox components that reduce chromium(VI) to reactive species capable of interacting with DNA. We have examined the role of glutathio...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02917282
更新日期：1989-07-01 00:00:00
abstract：:The protective effects of caffeic acid on angiotensin-converting enzyme (ACE) and purinergic enzyme activities, as well as gluconeogenesis was investigated in iron-induced cardiotoxicity. Cardiotoxicity was induced in heart tissues harvested from healthy male SD rats by 0.1 mM FeSO4. Treatment was carried out by co-in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02227-3
更新日期：2021-03-01 00:00:00
abstract：:Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0282-y
更新日期：2015-09-01 00:00:00
abstract：:Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:3:251
更新日期：2001-06-01 00:00:00
abstract：:The metabolism of 203Hg-labeled methylmercury chloride (MeHg) has been studied in rabbits and hamsters. Rabbits were administered 1.6 mumols MeHgCl/kg bw intravenously, and hamsters 40 mumols/kg bw orally. Urine and feces were collected daily and groups of four animals killed after 1 h, 1 d, or 7 d. The concentration ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917256
更新日期：1989-07-01 00:00:00
abstract：:Microbeam X-ray spectrometry, energy-dispersive X-ray fluorescence analysis, and neutron activation analysis were evaluated for the detection of selenium contained in the selenoprotein glutathione peroxidase. The glutathione peroxidase had been previously separated using polyacrylamide gel electrophoresis. The use of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917328
更新日期：1994-10-01 00:00:00
abstract：:Extracellular Ca2+-influx induced by trivalent metal ions (Fe3+, Al3+, Cr3+, In3+, Ga3+, and La3+) in Ehrlich carcinoma cells is enhanced by ATP. This action seems to be related to the high coordination capacity of the ATP ligand that inhibits the polymerization of the solvated cations taking place at physiological pH...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02820027
更新日期：1998-04-01 00:00:00
abstract：:The present study was designed to investigate the effects of montmorillonite (MMT) on dietary Cd-induced oxidative damage in liver and kidney of carp (Carassius auratus). One hundred eighty carp were randomly divided into four groups and fed with a basal diet, a basal diet supplemented with 0.5% MMT, Cd-comtaminated b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8735-9
更新日期：2011-06-01 00:00:00
abstract：:The purpose of this study was to analyze the existing studies and to investigate the relationship between children's full-scale intelligence quotient (FIQ), verbal IQ (VIQ), and performance IQ (PIQ) and their blood lead (Pb) and zinc (Zn) levels. All documents in Chinese and English were collected from the PubMed, Web...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12011-017-1093-0
更新日期：2018-04-01 00:00:00
abstract：:Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02468-2
更新日期：2020-11-05 00:00:00
abstract：:Cadmium (Cd) exposure has been recognized to result in a wide variety of cellular responses, including oxidative stress and body weight loss. The aim of the present study was to examine the effect of lycopene supplementation on the antioxidant defense system, lipid peroxidation (LPO) level, nitric oxide (NO), tumor ne...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0027-7
更新日期：2007-08-01 00:00:00
