Abstract:
:Selenium selenate was administered to streptozotocin-induced diabetic rats to assess its effects on the detrusor muscle. Thirty-two rats were divided into four groups of eight subjects each. The study animals were made diabetic by means of a single intravenous injection of streptozotocin (STZ). The responsiveness of the detrusor was improved in the group injected with sodium selenate. Diabetes caused significant increases in carbachol and beta,gamma-MeATP-evoked contractions and significant decrease of contractions induced by electrical stimulation. Isoprenaline-induced relaxation of the detrusor muscle was diminished by diabetes, whereas ATP relaxation appeared to be increased. Although adenosine-induced relaxations in controls and in diabetic rats were accompanied by unchanged responses in normoxic conditions, a significant enhancement in the detrusor muscle was observed during hypoxia. This enhancement of adenosine responsiveness in hypoxic conditions is inhibited in diabetes. Treatment with sodium selenate prevented alterations of both carbachol-induced contractility and isoprenaline-evoked relaxation, whereas nerve-mediated contractions and purinergic responses were not improved in diabetic rats after treatment. Our data suggest that changes in cholinergic and adrenergic responses were the result of selenium deficiency in diabetic rats.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Gür S,Cinel Idoi
10.1385/BTER:93:1-3:171subject
Has Abstractpub_date
2003-07-01 00:00:00pages
171-88issue
1-3eissn
0163-4984issn
1559-0720pii
BTER-93-1-3-171journal_volume
93pub_type
杂志文章abstract::An experimental study was conducted in Wistar rats to characterize the arsenic ("As")-induced alterations in neurobiochemistry in brain and its impact on neuropharmacological activities with or without the melatonin (MLT) as an antioxidant given exogenously. Male Wistar rats were randomly divided in to four groups of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1537-1
更新日期:2019-07-01 00:00:00
abstract::Both thermal and epithermal neutron activation analyses have been employed to determine chromium and nickel in lung tissue and arsenic in urine. Based on accuracy, precision, and detection limits, these techniques have been successfully used to analyze lung tissue from a deceased welder, who died, from cancer, and to ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796646
更新日期:1987-08-01 00:00:00
abstract::Selenium (Se) is an essential trace element in animals and human, however, excess Se intake can result in adverse health effects. Se supplementation increased glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR) expressions in Se-deficient rats. However, little information is available on the relationship be...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:89:2:165
更新日期:2002-11-01 00:00:00
abstract::Cantharellus cibarius Fr. (chanterelle) and Boletus badius Pers. (bay bolete) harvested from natural sites in Poland were used to derive in vitro cultures. The optimal medium composition for cultures was developed. Concentrations of the chosen elements (Zn, Cu, Fe, Mg, Ni, and Cd) in mycelium samples were measured by ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9670-3
更新日期:2013-06-01 00:00:00
abstract::Oxidative stress is a main factor in the pathogenesis of severe acute pancreatitis (SAP). The ability of zinc (Zn) to retard oxidative processes has been recognized for many years. This study aims to examine the levels of free oxygen radicals and antioxidant enzyme in SAP rats and know the effect of Zn supplementation...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9971-1
更新日期:2014-06-01 00:00:00
abstract::To elucidate the action of the myocardial bridge (MB) on the coronary artery, the authors first prepared the hearts with the MB located in the middle one third of the left anterior descending (LAD) artery and then investigated element accumulation in the LAD artery of the hearts with the MB by direct chemical analysis...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0498-x
更新日期:2016-05-01 00:00:00
abstract::To investigate the protective effect of garlic powder on cadmium-induced toxicity sea bass liver, juvenile fishes where maintained under three food diets (diet 1: normal without garlic supply, diet 2: 2% garlic powder; diet 3: 6% garlic powder). After 30 days of specific diets, each group was injected with 500 μg kg-1...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1146-4
更新日期:2018-06-01 00:00:00
abstract::This study investigated the effects of ethanol (EtOH) on manganese (Mn)-induced striatal toxicity in rat by evaluating the neurobehavioral changes, biochemical and molecular events in rats exposed to Mn alone at 30 mg/kg, or their combination with EtOH at 1.25- and 5-g/kg body weight for 35 consecutive days. Locomotiv...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1587-4
更新日期:2019-09-01 00:00:00
abstract::Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0061-5
更新日期:2007-01-01 00:00:00
abstract::Zinc, copper, and selenium statuses were reported to be linked to the development of chronic diseases, especially coronary heart disease (CHD). Metabolic syndrome, a known CHD risk factor, was found to be highly prevalent in Lebanon. Nevertheless, no data are available on the statuses of plasma zinc, copper, and selen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8112-0
更新日期:2008-07-01 00:00:00
abstract::The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However, no properly confirmed tumor regression was reported so...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-009-8486-7
更新日期:2010-06-01 00:00:00
abstract::In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses. Se-AbM was administrated before ethanol administration. Subseque...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0022-8
更新日期:2014-07-01 00:00:00
abstract::This study was conducted to investigate the effect of zinc chitosan chelate (CS-Zn) on zinc transporter expression and content of tissue zinc in weaned piglets. A total of 90 weaned pigs (Duroc × Landrace × Yorkshire) were randomly allocated to treatment groups with supplementation of 100 mg/kg zinc as ZnSO4, 100 mg/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-016-0732-1
更新日期:2016-12-01 00:00:00
abstract::The present study was undertaken to investigate the utility of cystatin C (CysC) as an early biomarker of cadmium (Cd)-induced renal injury. The study was carried out on 50 adult male individuals divided into five groups of 10 individuals as follows: control, welders, smoker welders, diabetic welders, and smoker diabe...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-9939-1
更新日期:2014-06-01 00:00:00
abstract::The main source of environmental arsenic exposure in most countries of the world is drinking water in which inorganic forms of arsenic predominate. The present study was aimed to test the impact of two different compounds of inorganic arsenic in histomorphometric and enzymatic parameters in the testes by oral expositi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0523-0
更新日期:2016-06-01 00:00:00
abstract::To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:88:3:203
更新日期:2002-09-01 00:00:00
abstract::Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0311-x
更新日期:2015-07-01 00:00:00
abstract::The zinc content in the hair of 654 children living in various rural and industrial areas in southern Poland was assayed by means of the atomic absorption spectrometry, following the dry digestion procedure. The hair of girls exhibited statistically significant higher level of Zn than the boys' hair, although in the s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790111
更新日期:1995-01-01 00:00:00
abstract::The objective was to determine if a mammary cell line shows glucocorticoid stimulation of Zn uptake, and to determine whether polyamines mediate this stimulation. 65Zn uptake by COMMA-1D mouse mammary epithelial cells over a 24-h period increased significantly in cells administered 10(-7) or 10(-6) M hydrocortisone. I...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783193
更新日期:1993-11-01 00:00:00
abstract::Biological half-lives of bromine in 15 different organs and tissues of the rat, in addition to the whole-body half-life, were determined by measuring the radioactive concentration of 82Br-bromide in samples of tissues collected at the time intervals of 12-396 h from animals that continuously (up to 17 d) received 82Br...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:76:1:57
更新日期:2000-07-01 00:00:00
abstract::The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9834-1
更新日期:2013-12-01 00:00:00
abstract::The new range of sealed-tube neutron generators developed by SODERN appears to be appropriate for the industrial environment. The main characteristics are the high emission stability during the very long lifetime of the tube, flexible pulsed mode capability, safety in operation with no radiation in "off" state, and th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917309
更新日期:1994-10-01 00:00:00
abstract::Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0282-y
更新日期:2015-09-01 00:00:00
abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:107:2:153
更新日期:2005-11-01 00:00:00
abstract::Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can decrease hyperglycemia; however, its biochemical mechanism remains unclear. The object of the present study is t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:74:3:237
更新日期:2000-06-01 00:00:00
abstract::Two experiments were performed to confirm that boron interacts with calcium, and that this interaction can be modified by dietary magnesium and potassium in the rat. Upon manipulating the dietary variables listed above, it was found that under certain conditions, boron and calcium deprivation similarly affected severa...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783768
更新日期:1992-12-01 00:00:00
abstract::A survey of mercury (Hg) and selenium (Se) contents was performed in fish collected from lakes located in two National Parks of the northern patagonian Andean range. Two native species, catfish (Diplomystes viedmensis) and creole perch (Percichthys trucha), and three introduced species, brown trout (Salmo trutta), rai...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8059-6
更新日期:2008-04-01 00:00:00
abstract::Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Z...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0965-7
更新日期:2017-10-01 00:00:00
abstract::Over the last decade, there has been an increased concern about the health risks from exposure to arsenic at low doses, because of their neurotoxic effects on the developing brain. The exact mechanism underlying arsenic-induced neurotoxicity during sensitive periods of brain development remains unclear, although enhan...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1286-1
更新日期:2018-11-01 00:00:00
abstract::Forty-six elements have been detected in fresh banana pulp purchased weekly in Pittsburgh, PA for the past twelve years (1968-1980). Samples were prepared by lyophilization or low temperature ashing. Analyses were performed using X-ray fluorescence spectrometry, optical emission spectrometry, atomic absorption spectro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789122
更新日期:1981-03-01 00:00:00