Abstract:
:The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme activity assay. Cardiac function was evaluated by hemodynamic parameters. ER stress markers immunoglobulin-binding protein (BiP)/glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) were detected by western blotting. Our data showed that myocardial GPx activity and cardiac function were conspicuously impaired in Se-deficient rats. Expression of GRP78 and CHOP was significantly upregulated by treatment of Se deficiency. Improvements in myocardial GPx activity and cardiac function, as well as decreases in expression of GRP78 and CHOP, were observed after Se supplementation. Consequently, our data show that ER stress was involved in Se deficiency-induced cardiac dysfunction.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Wang SQ,Niu XL,Liu ZW,Zhu YH,Gao DFdoi
10.1007/s12011-013-9834-1subject
Has Abstractpub_date
2013-12-01 00:00:00pages
196-201issue
1-3eissn
0163-4984issn
1559-0720journal_volume
156pub_type
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journal_title:Biological trace element research
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