Selenium deficiency is associated with endoplasmic reticulum stress in a rat model of cardiac malfunction.

Abstract:

:The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme activity assay. Cardiac function was evaluated by hemodynamic parameters. ER stress markers immunoglobulin-binding protein (BiP)/glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) were detected by western blotting. Our data showed that myocardial GPx activity and cardiac function were conspicuously impaired in Se-deficient rats. Expression of GRP78 and CHOP was significantly upregulated by treatment of Se deficiency. Improvements in myocardial GPx activity and cardiac function, as well as decreases in expression of GRP78 and CHOP, were observed after Se supplementation. Consequently, our data show that ER stress was involved in Se deficiency-induced cardiac dysfunction.

journal_name

Biol Trace Elem Res

authors

Wang SQ,Niu XL,Liu ZW,Zhu YH,Gao DF

doi

10.1007/s12011-013-9834-1

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

196-201

issue

1-3

eissn

0163-4984

issn

1559-0720

journal_volume

156

pub_type

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