Abstract:
:We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 mo of each treatment at random order over 1 yr). We present preliminary results of 24 children who completed the study (3 girls, 21 boys, age 9-13 yr). Subjects had to be prepubertal, with no GH deficiency diagnosed. In 15 subjects growth velocity was lower than 5 mm/mo: In this case ZA improved growth velocity (rising from 3.105 +/- 0.229 to 5.4 +/- 0.69 mm/mo p < 0.01), whereas the effect of AA was not significant. The increase in growth velocity was higher with ZA (+2.44 +/- 0.657 mm/mo) than AA (+0.438 +/- 0.450 mm/mo) p < 0.05. These results suggest that ZA is more efficient than AA, consistent with the hypothesis that zinc needs are increased in those children in this period of life.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Fons C,Brun JF,Fedou C,Fussellier M,Bardet L,Orsetti Adoi
10.1007/BF02789076subject
Has Abstractpub_date
1995-04-01 00:00:00pages
31-6issue
1eissn
0163-4984issn
1559-0720journal_volume
48pub_type
临床试验,杂志文章,随机对照试验abstract::Various studies indicate the role of manganese (Mn) in the virulence of pathogens. Salmonella is an intracellular pathogen which is able to multiply within the macrophages. The present study was therefore, designed to assess the effect of Mn supplementation on Salmonella-macrophage interactions particularly in referen...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8406-x
更新日期:2010-01-01 00:00:00
abstract:UNLABELLED:There is conflicting evidence regarding the relationship between magnesium deficiency and metabolic syndrome, and a systematic assessment of the literature has not been performed. Our objective was to clarify the association between magnesium levels and metabolic syndrome by performing a meta-analysis. Based...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析
doi:10.1007/s12011-015-0446-9
更新日期:2016-03-01 00:00:00
abstract::The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795531
更新日期:1986-12-01 00:00:00
abstract::Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0311-x
更新日期:2015-07-01 00:00:00
abstract::The purpose of current study was to determine the step at which dietary selenium (Se) regulates the transcriptional expression of the gene for Se-glutathione peroxidase (Se-GPx) in rat brain and transplanted glioma tissue. Wistar rats were fed a Se-free diet or the same diet supplemented with 0.5, 2.0, and 4.0 mg Se/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:73:1:67
更新日期:2000-01-01 00:00:00
abstract::Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784077
更新日期:1996-03-01 00:00:00
abstract::Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences in the serum levels of Cu, Se, and Zn did exist. Forty males/60 fem...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8571-y
更新日期:2010-11-01 00:00:00
abstract::Zinc and fluorides are capable of modifying the process of bone formation and mineralization. Statistically significant differences have been revealed in the content of zinc and fluorides between structures of the femur in chicken. The content of zinc in compact bone remained constant during the first 50 d of life. Lo...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:91:1:67
更新日期:2003-01-01 00:00:00
abstract::Although fish consumption has positive health effects, metals accumulated in fish can cause human health risks. In this study, the levels of ten metals in rainbow trout (Oncorhynchus mykiss) farmed in the Keban Dam Reservoir, which has the biggest rainbow trout production capacity in Turkey, were determined and compar...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1156-2
更新日期:2018-07-01 00:00:00
abstract::Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma op...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01907-z
更新日期:2020-07-01 00:00:00
abstract::Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diab...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-015-0231-9
更新日期:2015-07-01 00:00:00
abstract::As Cr(III) compounds have been shown to increase insulin sensitivity and decrease plasma cholesterol and triglycerides in rodent models of diabetes and insulin resistance and as colorectal cancer risk has been associated with insulin resistance and diabetes, the effects of the Cr(III) compound Cr3 ([Cr3O(O2CCH2CH3)6(H...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0346-z
更新日期:2015-11-01 00:00:00
abstract::The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795448
更新日期:1988-09-01 00:00:00
abstract::Serum copper and zinc estimations in humans were made to find their diagnostic and prognostic value in cases of myocardial infarction. Following infarction, there was an increase in serum copper levels from the first 24 h up to the 7th day, with gradual decline that did not reach the normal value up to the 14th day. T...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990200
更新日期:1991-12-01 00:00:00
abstract::This study was initiated to examine if variations in the concentrations of cadmium (Cd) and lead (Pb) in water environment may affect metal levels in local foods and body burden of local residents in non-polluted areas in Japan. Two nationwide databases have been made available on concentrations of Cd in locally harve...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8436-4
更新日期:2010-03-01 00:00:00
abstract::Although lead is known to induce arterial hypertension and vascular damage, it is not clear if after cessation of lead treatment, the increase of blood pressure is sustained and the vascular function is different from untreated rats. Therefore, we aimed to evaluate the systolic blood pressure during and following lead...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0497-y
更新日期:2016-04-01 00:00:00
abstract::An in vitro system employing collagen isolated from the sheep tendons to induce mineralization and demineralization reactions was used not only to study the effect of various concentrations of fluoride on the collagen-induced mineralization and demineralization reactions but also to compare their action with the inhib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02340-3
更新日期:2020-08-27 00:00:00
abstract::The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917205
更新日期:1990-03-01 00:00:00
abstract::Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Admini...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1341-y
更新日期:2018-12-01 00:00:00
abstract::Since chromium(VI) is unreactive toward DNA under physiological conditions in vitro, the ability of carcinogenic chromium(VI) compounds to damage DNA depends on the presence of cellular redox components that reduce chromium(VI) to reactive species capable of interacting with DNA. We have examined the role of glutathio...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02917282
更新日期:1989-07-01 00:00:00
abstract::Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective functions cannot be solely attributed to the action of glutathione peroxidase. Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stres...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02783992
更新日期:1992-04-01 00:00:00
abstract::The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:102:1-3:209
更新日期:2004-01-01 00:00:00
abstract::Fluoride can induce neurotoxicity, but the mechanism is not clear. In this study, we explored the role of autophagy in F--induced neurotoxicity of Wistar rats. Eighty Wistar rats were randomly divided into four groups: the control group (distilled water containing less than 0.1 mg/L F-) and three NaF-treated groups (F...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01735-1
更新日期:2020-02-01 00:00:00
abstract::The concentrations of elements in urine obtained from cats with urolithiasis were compared with those of healthy cats. The concentration of several elements, such as sodium (Na), phosphorus (P), sulfur (S), and potassium (K), in urine obtained from cats with urolithiasis was significantly higher than that of healthy c...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8893-9
更新日期:2011-11-01 00:00:00
abstract::Present study was undertaken to study the effect of 28-days exposure of female adult rats to cadmium (Cd) in drinking water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca2+ levels in bl...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1040-0
更新日期:2018-02-01 00:00:00
abstract::Injectable trace minerals (ITMs) could provide a potential alternative way of trace mineral delivery for sick animals. Therefore, evaluation of ameliorative potentials of ITMs (copper, manganese, selenium, and zinc) on the circulating Th1/Th2 cytokine misbalance in Theileria annulata-infected calves was aimed. Forty-t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02263-z
更新日期:2020-06-22 00:00:00
abstract::Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02402-6
更新日期:2020-10-06 00:00:00
abstract::Antioxidants can play a significant role in chronic inflammatory process. The aim of this study was to evaluate the content of selenium (Se), zinc (Zn), copper (Cu), and total antioxidant status (TAS) of patients with chronic tonsillitis (CT). The study group consisted of 84 patients with CT from 18 to 62 years old an...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-016-0634-2
更新日期:2016-09-01 00:00:00
abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:107:2:153
更新日期:2005-11-01 00:00:00
abstract::Footrot (FR) is a common, contagious bacterial disease of sheep that results in lameness and significant economic losses for producers. We previously reported that sheep affected with FR have lower whole-blood (WB) selenium (Se) concentrations and that Se supplementation in conjunction with routine control practices a...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9716-6
更新日期:2013-07-01 00:00:00