Effects of zamic as a means for zinc supplementation in growing children.

Abstract:

:We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 mo of each treatment at random order over 1 yr). We present preliminary results of 24 children who completed the study (3 girls, 21 boys, age 9-13 yr). Subjects had to be prepubertal, with no GH deficiency diagnosed. In 15 subjects growth velocity was lower than 5 mm/mo: In this case ZA improved growth velocity (rising from 3.105 +/- 0.229 to 5.4 +/- 0.69 mm/mo p < 0.01), whereas the effect of AA was not significant. The increase in growth velocity was higher with ZA (+2.44 +/- 0.657 mm/mo) than AA (+0.438 +/- 0.450 mm/mo) p < 0.05. These results suggest that ZA is more efficient than AA, consistent with the hypothesis that zinc needs are increased in those children in this period of life.

journal_name

Biol Trace Elem Res

authors

Fons C,Brun JF,Fedou C,Fussellier M,Bardet L,Orsetti A

doi

10.1007/BF02789076

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

31-6

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

48

pub_type

临床试验,杂志文章,随机对照试验
  • Salmonella-macrophage interactions upon manganese supplementation.

    abstract::Various studies indicate the role of manganese (Mn) in the virulence of pathogens. Salmonella is an intracellular pathogen which is able to multiply within the macrophages. The present study was therefore, designed to assess the effect of Mn supplementation on Salmonella-macrophage interactions particularly in referen...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8406-x

    authors: Rishi P,Jindal N,Bharrhan S,Tiwari RP

    更新日期:2010-01-01 00:00:00

  • Low Magnesium Levels in Adults with Metabolic Syndrome: a Meta-Analysis.

    abstract:UNLABELLED:There is conflicting evidence regarding the relationship between magnesium deficiency and metabolic syndrome, and a systematic assessment of the literature has not been performed. Our objective was to clarify the association between magnesium levels and metabolic syndrome by performing a meta-analysis. Based...

    journal_title:Biological trace element research

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12011-015-0446-9

    authors: La SA,Lee JY,Kim DH,Song EL,Park JH,Ju SY

    更新日期:2016-03-01 00:00:00

  • Parenteral zinc and tissue metallothionein in normal and diabetic rats.

    abstract::The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02795531

    authors: Lin LY,McCormick CC

    更新日期:1986-12-01 00:00:00

  • Chromium Is Elevated in Fin Whale (Balaenoptera physalus) Skin Tissue and Is Genotoxic to Fin Whale Skin Cells.

    abstract::Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0311-x

    authors: Wise CF,Wise SS,Thompson WD,Perkins C,Wise JP Sr

    更新日期:2015-07-01 00:00:00

  • Selenium and glutathione peroxidase mRNA in rat glioma.

    abstract::The purpose of current study was to determine the step at which dietary selenium (Se) regulates the transcriptional expression of the gene for Se-glutathione peroxidase (Se-GPx) in rat brain and transplanted glioma tissue. Wistar rats were fed a Se-free diet or the same diet supplemented with 0.5, 2.0, and 4.0 mg Se/k...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/bter:73:1:67

    authors: Zhang Z,Miyatake S,Saiki M,Asahi M,Yukawa H,Toda H,Kikuchi H,Yoshimura SI,Hashimoto N

    更新日期:2000-01-01 00:00:00

  • Evidence for altered structure and impaired mitochondrial electron transport function in selenium deficiency.

    abstract::Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784077

    authors: Rani P,Lalitha K

    更新日期:1996-03-01 00:00:00

  • Serum levels of Cu, Se, and Zn in adult rural/urban residents in Ghana: paradigm shift?

    abstract::Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences in the serum levels of Cu, Se, and Zn did exist. Forty males/60 fem...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8571-y

    authors: Asare GA,Nani A

    更新日期:2010-11-01 00:00:00

  • Changes in the content of zinc and fluoride during growth of the femur in chicken.

    abstract::Zinc and fluorides are capable of modifying the process of bone formation and mineralization. Statistically significant differences have been revealed in the content of zinc and fluorides between structures of the femur in chicken. The content of zinc in compact bone remained constant during the first 50 d of life. Lo...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:91:1:67

    authors: Dołegowska B,Machoy Z,Chlubek D

    更新日期:2003-01-01 00:00:00

  • Trace Metal Levels in Rainbow Trout (Oncorhynchus mykiss) Cultured in Net Cages in a Reservoir and Evaluation of Human Health Risks from Consumption.

    abstract::Although fish consumption has positive health effects, metals accumulated in fish can cause human health risks. In this study, the levels of ten metals in rainbow trout (Oncorhynchus mykiss) farmed in the Keban Dam Reservoir, which has the biggest rainbow trout production capacity in Turkey, were determined and compar...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1156-2

    authors: Varol M,Kaya GK,Alp SA,Sünbül MR

    更新日期:2018-07-01 00:00:00

  • Investigative Analysis of Lanthanum Oxide Nanoparticles on Elements in Bone of Wistar Rats After 30 Days of Repeated Oral Administration.

    abstract::Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma op...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01907-z

    authors: Dressler VL,Ogunmodede OT,Heidrich GM,Neves VM,Schetinger MRC,Morsch VM

    更新日期:2020-07-01 00:00:00

  • Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?

    abstract::Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diab...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审

    doi:10.1007/s12011-015-0231-9

    authors: Vincent JB

    更新日期:2015-07-01 00:00:00

  • Trivalent Chromium has no Effect on Delaying Azoxymethane-Induced Colorectal Cancer in FVB/NJ Mice.

    abstract::As Cr(III) compounds have been shown to increase insulin sensitivity and decrease plasma cholesterol and triglycerides in rodent models of diabetes and insulin resistance and as colorectal cancer risk has been associated with insulin resistance and diabetes, the effects of the Cr(III) compound Cr3 ([Cr3O(O2CCH2CH3)6(H...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0346-z

    authors: White PE,Deng G,Kuykendall MK,Tadros AM,Dyroff SL,Honan RE,Robertson PM,Vincent JB,Rasco JF

    更新日期:2015-11-01 00:00:00

  • Effects of traces of rare earth elements on the protozoan Blepherisma and on mice.

    abstract::The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02795448

    authors: Zhang WD,Li FQ,Zhang XY,Chen Y

    更新日期:1988-09-01 00:00:00

  • Serum zinc and copper in myocardial infarction with particular reference to prognosis.

    abstract::Serum copper and zinc estimations in humans were made to find their diagnostic and prognostic value in cases of myocardial infarction. Following infarction, there was an increase in serum copper levels from the first 24 h up to the 7th day, with gradual decline that did not reach the normal value up to the 14th day. T...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990200

    authors: Jain VK,Mohan G

    更新日期:1991-12-01 00:00:00

  • Effects of variations in cadmium and lead levels in river sediments on local foods and body burden of local residents in non-polluted areas in Japan.

    abstract::This study was initiated to examine if variations in the concentrations of cadmium (Cd) and lead (Pb) in water environment may affect metal levels in local foods and body burden of local residents in non-polluted areas in Japan. Two nationwide databases have been made available on concentrations of Cd in locally harve...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8436-4

    authors: Ikeda M,Watanabe T,Ohashi F,Shimbo S

    更新日期:2010-03-01 00:00:00

  • Blood Pressure Decreases Following Lead Treatment Cessation: Highest NO Bioavailability Involved.

    abstract::Although lead is known to induce arterial hypertension and vascular damage, it is not clear if after cessation of lead treatment, the increase of blood pressure is sustained and the vascular function is different from untreated rats. Therefore, we aimed to evaluate the systolic blood pressure during and following lead...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0497-y

    authors: Broseghini-Filho GB,Almenara CC,Vassallo DV,Padilha AS

    更新日期:2016-04-01 00:00:00

  • Fluoride and Biological Calcification I: Effect of Fluoride on Collagen-Induced In Vitro Mineralization and Demineralization Reactions.

    abstract::An in vitro system employing collagen isolated from the sheep tendons to induce mineralization and demineralization reactions was used not only to study the effect of various concentrations of fluoride on the collagen-induced mineralization and demineralization reactions but also to compare their action with the inhib...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02340-3

    authors: Kakkar M,Kapoor V,Singla SK,Jethi RK

    更新日期:2020-08-27 00:00:00

  • An interaction between selenate and a sulfate transporter in the lactating rat mammary gland.

    abstract::The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02917205

    authors: Shennan DB,McNeillie SA

    更新日期:1990-03-01 00:00:00

  • Alleviation Mechanisms of Selenium on Cadmium-Spiked in Chicken Ovarian Tissue: Perspectives from Autophagy and Energy Metabolism.

    abstract::Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Admini...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1341-y

    authors: Wang S,Xu Z,Yin H,Min Y,Li S

    更新日期:2018-12-01 00:00:00

  • Mechanism of chromium(VI) carcinogenesis. Reactive intermediates and effect on gene expression.

    abstract::Since chromium(VI) is unreactive toward DNA under physiological conditions in vitro, the ability of carcinogenic chromium(VI) compounds to damage DNA depends on the presence of cellular redox components that reduce chromium(VI) to reactive species capable of interacting with DNA. We have examined the role of glutathio...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审

    doi:10.1007/BF02917282

    authors: Wetterhahn KE,Hamilton JW,Aiyar J,Borges KM,Floyd R

    更新日期:1989-07-01 00:00:00

  • Selenium. Mechanistic aspects of anticarcinogenic action.

    abstract::Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective functions cannot be solely attributed to the action of glutathione peroxidase. Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stres...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审

    doi:10.1007/BF02783992

    authors: Schrauzer GN

    更新日期:1992-04-01 00:00:00

  • Effects of taurine on oxidative stress parameters and chromium levels altered by acute hexavalent chromium exposure in mice kidney tissue.

    abstract::The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:102:1-3:209

    authors: Boşgelmez II,Güvendik G

    更新日期:2004-01-01 00:00:00

  • Autophagy May Be Involved in Fluoride-Induced Learning Impairment in Rats.

    abstract::Fluoride can induce neurotoxicity, but the mechanism is not clear. In this study, we explored the role of autophagy in F--induced neurotoxicity of Wistar rats. Eighty Wistar rats were randomly divided into four groups: the control group (distilled water containing less than 0.1 mg/L F-) and three NaF-treated groups (F...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01735-1

    authors: Zhang C,Huo S,Fan Y,Gao Y,Yang Y,Sun D

    更新日期:2020-02-01 00:00:00

  • The distribution of several elements in cat urine and the relation between the content of elements and urolithiasis.

    abstract::The concentrations of elements in urine obtained from cats with urolithiasis were compared with those of healthy cats. The concentration of several elements, such as sodium (Na), phosphorus (P), sulfur (S), and potassium (K), in urine obtained from cats with urolithiasis was significantly higher than that of healthy c...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8893-9

    authors: Mochizuki M,Morikawa M,Yogo T,Urano K,Ishioka K,Kishi M,Hondo R,Ueda F,Sako T,Sakurai F,Yumoto N,Tagawa M

    更新日期:2011-11-01 00:00:00

  • Dose-Dependent Differential Effects of In Vivo Exposure of Cadmium on Myometrial Activity in Rats: Involvement of VDCC and Ca2+-Mimicking Pathways.

    abstract::Present study was undertaken to study the effect of 28-days exposure of female adult rats to cadmium (Cd) in drinking water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca2+ levels in bl...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1040-0

    authors: Saroj VK,Nakade UP,Sharma A,Choudhury S,Hajare SW,Garg SK

    更新日期:2018-02-01 00:00:00

  • Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis.

    abstract::Injectable trace minerals (ITMs) could provide a potential alternative way of trace mineral delivery for sick animals. Therefore, evaluation of ameliorative potentials of ITMs (copper, manganese, selenium, and zinc) on the circulating Th1/Th2 cytokine misbalance in Theileria annulata-infected calves was aimed. Forty-t...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02263-z

    authors: Ram PK,Singh SK,Srivastava A,Kumar G,Jaiswal AK,Yadav B,Garg SK

    更新日期:2020-06-22 00:00:00

  • Inorganic Iron Supplementation Rescues Hematological Insufficiency Even Under Intense Exercise Training in a Mouse Model of Iron Deficiency with Anemia.

    abstract::Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02402-6

    authors: Sumi K,Munakata K,Konno S,Ashida K,Nakazato K

    更新日期:2020-10-06 00:00:00

  • Selenium, Zinc, Copper, and Total Antioxidant Status in the Serum of Patients with Chronic Tonsillitis.

    abstract::Antioxidants can play a significant role in chronic inflammatory process. The aim of this study was to evaluate the content of selenium (Se), zinc (Zn), copper (Cu), and total antioxidant status (TAS) of patients with chronic tonsillitis (CT). The study group consisted of 84 patients with CT from 18 to 62 years old an...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12011-016-0634-2

    authors: Michalska-Mosiej M,Socha K,Soroczyńska J,Karpińska E,Łazarczyk B,Borawska MH

    更新日期:2016-09-01 00:00:00

  • Effects of dietary zinc levels on the activities of enzymes, weights of organs, and the concentrations of zinc and copper in growing rats.

    abstract::Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study was performed to investigate the effects of three Zn levels, including Zn adequate (35.94 mg/kg, as a control), Zn deficienc...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:107:2:153

    authors: Sun JY,Jing MY,Weng XY,Fu LJ,Xu ZR,Zi NT,Wang JF

    更新日期:2005-11-01 00:00:00

  • Selenium supplementation alters gene expression profiles associated with innate immunity in whole-blood neutrophils of sheep.

    abstract::Footrot (FR) is a common, contagious bacterial disease of sheep that results in lameness and significant economic losses for producers. We previously reported that sheep affected with FR have lower whole-blood (WB) selenium (Se) concentrations and that Se supplementation in conjunction with routine control practices a...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-013-9716-6

    authors: Hugejiletu H,Bobe G,Vorachek WR,Gorman ME,Mosher WD,Pirelli GJ,Hall JA

    更新日期:2013-07-01 00:00:00