An interaction between selenate and a sulfate transporter in the lactating rat mammary gland.

Abstract:

:The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange inhibitor DIDS. The effect of selenate on sulfate efflux was saturable with an apparent affinity constant of approximately 0.27 mM. In addition, molybdate and thiosulfate were also found to increase sulfate efflux from the trans-aspect. It is concluded that sulfate and selenate share a pathway for transport in the lactating rat mammary gland.

journal_name

Biol Trace Elem Res

authors

Shennan DB,McNeillie SA

doi

10.1007/BF02917205

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

173-82

issue

3

eissn

0163-4984

issn

1559-0720

journal_volume

24

pub_type

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