Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis.

Abstract:

:Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = -4.86, 95% CI -6.03-3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42-0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50-4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

journal_name

Biol Trace Elem Res

authors

He D,Wang Z,Huang C,Fang X,Chen D

doi

10.1007/s12011-017-0982-6

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

195-202

issue

2

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-017-0982-6

journal_volume

179

pub_type

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