Abstract：
:Metabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecular mechanism affecting metabolic pathways. CaFB due to its cis-diol-rich feature may have the potential to interact with molecules taking part in cancer development. This study was aimed to investigate the effects of CaFB on metabolic alterations and inflammation in 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin cancer. For this purpose, 92 Balb-c mice were distributed into 6 groups as control, CaFB, DMBA/TPA (D-T), treatment 1 (T1), 2 (T2), and 3(T3). Apart from control and CaFB in other groups, tumors initiated with 97.5-nmol DMBA and 6.5-nmol TPA. Treatment groups received 3 mg/kg/day CaFB with DMBA (T1), with TPA (T2), and after tumor formation (T3). In the D-T group, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, 6-phosphogluconate dehydrogenase (PGD), glutathione (GSH), interleukin 6 (IL-6), (IL-1β), tumor necrosis factor-α (TNF-α) levels increased (p < 0.001) while malondialdehyde (MDA) levels decreased (p < 0.001) compared with that in control. CaFB application ameliorated DMBA-TPA effect according to the distribution time. It is noteworthy to consider CaFB as a potential preventive agent in skin cancer development.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Kisacam MA,Kocamuftuoglu GO,Ozan IE,Yaman M,Ozan Sdoi
10.1007/s12011-020-02363-wsubject
Has Abstractpub_date
2020-09-03 00:00:00eissn
0163-4984issn
1559-0720pii
10.1007/s12011-020-02363-wpub_type
杂志文章abstract：:Zinc absorption from the alimentary tract, as revealed by serum zinc concentration, was studied in a group of 10 patients (age 37.7+/-5.1 yr) with moderate and severe untreated primary arterial hypertension before and after a 30-d treatment with perindopril 4 mg/d. Blood pressure was 177.33+/-16.24/111.33+/-15.26 mm H...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:83:1:31
更新日期：2001-10-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8059-6
更新日期：2008-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-8994-0
更新日期：2011-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917205
更新日期：1990-03-01 00:00:00
abstract：:Aspirin is widely used as an antiinflammatory drug especially in children with rheumatic fever arthritis. The diminishing effects of aspirin on antioxidant enzymes and hepato-renal systems at high doses are well-known. It is now evident that the damage at antioxidant system worsens the clinical picture of the disease ...
journal_title：Biological trace element research
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doi：10.1007/s12011-008-8115-x
更新日期：2008-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02241-5
更新日期：2020-06-16 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783258
更新日期：1982-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0234-6
更新日期：2015-06-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789032
更新日期：1980-03-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917374
更新日期：1994-10-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:114:1:175
更新日期：2006-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02783992
更新日期：1992-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02481-5
更新日期：2020-11-20 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9834-1
更新日期：2013-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02790138
更新日期：1995-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8351-8
更新日期：2009-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02402-6
更新日期：2020-10-06 00:00:00
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journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02785281
更新日期：1996-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783841
更新日期：1979-03-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8391-0
更新日期：2009-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9913-y
更新日期：2014-04-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9739-z
更新日期：2013-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8933-5
更新日期：2011-11-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8676-3
更新日期：2011-04-01 00:00:00
abstract：:Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1531-7
更新日期：2019-03-01 00:00:00
abstract：:Prostate cancer is one of the most common cancers and the second cause of cancer-related deaths among men. Metals are recognized as chemical carcinogens where chronic exposures to such metals are implicated in the development of cancer, including prostate cancer. This in vitro study demonstrates the relative death sen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0100-y
更新日期：2014-12-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992691
更新日期：1990-07-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789141
更新日期：1990-01-01 00:00:00
abstract：:Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0117-2
更新日期：2014-12-01 00:00:00
abstract：:The objective of the study was to evaluate the maximum tolerance limit of amino acid copper complex (Cu-Lys-Glu) for laying hens by measuring their laying performance, hematological and serum biochemical parameters, organ index, and histopathology. A total of 450 18-week-old Beijing White layers were randomly allocate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02406-2
更新日期：2020-10-12 00:00:00
