Abstract:
:The incorporation of(3)H-thymidine into DNA in the brains of the 17-day and 20-day old rat fetuses was significantly reduced by maternal zinc restriction during pregnancy. The activity of the enzyme thymidine kinase (EC 2.7.1.21) was similarly reduced in the zine-deprived fetal brains on days 14 and 20 of gestation, but not on day 17. Fetal brain alkaline phosphatase (EC 3.1.3.1) was significantly depressed by maternal zinc deprivation on days 17 and 20 of pregnancy.The data suggest an association between thymidine kinase and the reduced incorporation of(3)H-thymidine into DNA in the brains of 20-day old fetuses but not in animals on day 17. Alkaline phosphatase was however depressed at this stage.The suggestion is made that because of the complexity of brain development, future biochemical studies in this area should concern specific structures in the brain at particular critical stages during neurogenesis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Dreosti IE,Record IR,Manuel SJdoi
10.1007/BF02789032subject
Has Abstractpub_date
1980-03-01 00:00:00pages
21-9issue
1eissn
0163-4984issn
1559-0720journal_volume
2pub_type
杂志文章abstract::The aim of the present study was to investigate the effect of selenium (Se) deficiency on the expression of the toll-like receptor (TLR) signal transduction pathway in the spleen of chickens and explore the relationship between the TLR4/TRIF/NF-κB signaling pathway and inflammatory spleen injury. A total of 200 one-da...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02173-0
更新日期:2021-02-01 00:00:00
abstract::The aim of this study was to analyze the effect of high dietary Fe on liver antioxidant status in mice fed a corn-oil-enriched diet. Male Balb/c mice were fed for 3 wk with a standard diet enriched with 5% by weight of corn oil with adequate Fe (FCO diet) or supplemented with 1% carbonyl Fe (FCOFe diet). The control g...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:113:2:177
更新日期:2006-11-01 00:00:00
abstract::Manganese (Mn) is an essential nutrient for both host and pathogen. Recent studies have demonstrated the nutritional immunity of Mn against Salmonella infection in mammals. To investigate the effect of high dietary Mn on immune responses of broilers following Salmonella challenge, 144 1-day-old male broilers were fed ...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1007/s12011-017-1060-9
更新日期:2018-02-01 00:00:00
abstract::The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02795448
更新日期:1988-09-01 00:00:00
abstract::Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02427-x
更新日期:2020-10-14 00:00:00
abstract::Currently, it is unclear which index of haematological parameters could be used to most easily monitor iron deficiency during endurance training. To address this question, 16 male Wistar rats were randomly assigned to two groups: a sedentary group (n = 8) and an exercised group (n = 8). Initially, animals in the exerc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9312-6
更新日期:2012-06-01 00:00:00
abstract::Manganese (Mn) pollution is an important environmental problem because of the potential toxicity to human and animal health. However, the effects of Mn on energy metabolism and autophagy are not clear. Consequently, we examined the effects of excessive and chronic exposure to Mn on liver function, oxidative stress, re...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-019-01960-8
更新日期:2020-09-01 00:00:00
abstract::Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p less than or equal to 0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02990346
更新日期:1991-08-01 00:00:00
abstract::In this study, lead acetate solution and porcine cerebral hydrolysate peptides (PCHPs) were administered to developing mice. Porcine cerebral protein pretreated by ultrasound was hydrolyzed with alcalase, and 11 peptide fragments were obtained by Matrix-assisted laser desorption ionization-time of flight mass spectrom...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0329-0
更新日期:2015-12-01 00:00:00
abstract::Descriptions of the effects of paraquat (P2+) on the peroxidation of liver microsomes are very divergent. Therefore, the presence of ferric iron in the medium and the activity of microsomal mixed-function oxidase system are two factors that we have taken into consideration to explain the discrepancies. The results sho...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790096
更新日期:1995-01-01 00:00:00
abstract::Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02402-6
更新日期:2020-10-06 00:00:00
abstract::A microcomputer-controlled irradiation and measurement system and a microprocessor-controlled sample changer have been installed at the SLOWPOKE-2 Facility at the Royal Military College of Canada (RMC). These systems can provide the gamut of instrumental neutron activation analysis (INAA) techniques for the analyst. C...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992658
更新日期:1990-07-01 00:00:00
abstract::To elucidate the action of the myocardial bridge (MB) on the coronary artery, the authors first prepared the hearts with the MB located in the middle one third of the left anterior descending (LAD) artery and then investigated element accumulation in the LAD artery of the hearts with the MB by direct chemical analysis...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0498-x
更新日期:2016-05-01 00:00:00
abstract::Concentrations of selected metals (Cu, Mn, Zn, Cd) in tea leaves were investigated. Samples included black, green, and other (red, white, yellow, and oolong) teas. They were purchased on a local market but they covered different countries of origin. Beverages like yerba mate, rooibos, and fruit teas were also included...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1140-x
更新日期:2018-06-01 00:00:00
abstract::Free oxygen radicals and insufficient antioxidant enzymes have been implicated in the pathogenesis of hypercholesterolemia (HC). Trace elements function as cofactors in antioxidant enzymes. Antioxidant system and trace elements were investigated in many different studies including HC, but these subjects have not been ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:98:2:119
更新日期:2004-05-01 00:00:00
abstract::Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1531-7
更新日期:2019-03-01 00:00:00
abstract::To examine whether there were differences between races in regard to age-related changes of elements and the relationships among elements in the arteries, the authors investigated both the renal arteries of Thai and Japanese. The Thai subjects consisted of 27 men and 11 women, ranging in age from 27 to 88 yr, whereas ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:106:3:219
更新日期:2005-09-01 00:00:00
abstract::The aim of this research was to assess plasma magnesium (Mg) concentration, the frequencies of activated T CD4+ and T CD8+ lymphocytes and B lymphocytes in adolescents with hyperthyroidism due to Graves' disease (GD), and to assess changes in the above-mentioned parameters during methimazole (MMI) treatment. The frequ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9690-z
更新日期:2013-06-01 00:00:00
abstract::Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:108:1-3:169
更新日期:2005-01-01 00:00:00
abstract::Selenium and methylmercuric chloride (MMC) interactions regarding cellular uptake and selenium protection on MMC toxicity have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) together with (3.5 or 5 microM) MMC. Cells...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:80:3:251
更新日期:2001-06-01 00:00:00
abstract::Although adriamycin (ADR) exhibits high anti-tumor efficacy in vitro, its clinical use in cancer chemotherapy is limited due to its high renal toxicity. This study investigated the mechanism of ADR nephropathy and the protective effect of selenium on ADR-induced kidney damage by analyzing of the relationship between s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9273-9
更新日期:2012-06-01 00:00:00
abstract::The main source of environmental arsenic exposure in most countries of the world is drinking water in which inorganic forms of arsenic predominate. The present study was aimed to test the impact of two different compounds of inorganic arsenic in histomorphometric and enzymatic parameters in the testes by oral expositi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0523-0
更新日期:2016-06-01 00:00:00
abstract::The present study aimed to investigate the prevalence of thrombocytopenia and its association with serum magnesium in a nationally representative cohort. A total of 8478 participants aged 18 years and over were recruited in a cross-sectional survey. Thrombocytopenia was defined as platelet count less than 150 × 10(9)/...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0406-4
更新日期:2016-01-01 00:00:00
abstract::X-ray Fluorescence (XRF) Analysis and Atomic Absorption Spectrophotometry (AAS) have been used in assessing heavy metal pollution from some gold mines in Ghana. The presence and levels of heavy metals in gold ore, gold tailings, inland waters, and river sediments have been determined. Using these techniques, the heavy...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992682
更新日期:1990-07-01 00:00:00
abstract::Several studies have investigated the relationship between serum and hair nickel (Ni) concentration and breast cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum and hair nickel levels and breast cancer. Nine studies determining...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12011-017-0949-7
更新日期:2017-09-01 00:00:00
abstract::Microcalorimetry was employed to investigate the action of Li(I) to aquatic ecosystem from the point view of bioenergetics. Tetrahymena thermophila BF5 was chosen as the model organism. The power-time curves of T. thermophila BF5 growth metabolism in the absence and presence of Li(I) were obtained. The corresponding t...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0040-x
更新日期:2007-10-01 00:00:00
abstract::We investigated the effects of zinc supplementation in case of moderate growth retardation in which GH treatment could not be used. Zamic (ZA, an association containing arginine, L-methionine, and zinc; from Aguettant pharmaceuticals) was compared with arginine aspartate (AA) (5 g) in a crossover randomized trial (6 m...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02789076
更新日期:1995-04-01 00:00:00
abstract::The present study was aimed at estimating the current (2012) dietary intake of arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) by the population of Catalonia, Spain. The temporal trends with respect to previous surveys, performed in 2000, 2005, and 2008, were also determined. For that purpose, metal concentrat...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0138-x
更新日期:2014-12-01 00:00:00
abstract::Heavy metals toxicity is a prevalent health problem particularly in developing countries. Mercury and cadmium are toxic elements that have no physiologic functions in human body. They should not be present in the human body by any concentration. Copper, on the other hand, is one of the elements that are essential for ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-015-0525-y
更新日期:2016-06-01 00:00:00
abstract::Interactions of clinical laboratory parameters with trace elements in knee-joint effusions might turn out to be potential diagnostic tool, increasing our pathophysiological understanding and knowledge on knee-joint effusions. Thus, the 11 clinical laboratory parameters, total protein, albumin, glucose, lactate dehydro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:79:2:139
更新日期:2001-02-01 00:00:00