Cytotoxicity of zinc chloride in mice in vivo.

Abstract:

:Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p less than or equal to 0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/kg body wt) treatment. The degree of clastogenicity was directly proportional to the concentrations (p less than or equal to 0.05, trend test) and indirectly to the period of treatment (p less than or equal to 0.05, ANOVA test). It induced a dose-dependent, statistically significant increase (Mann-Whitney U statistics, Student's t-test) in sperm-head abnormalities. The data designate ZnCl2 as a potent clastogen and as a toxic chemical at the concentrations used.

journal_name

Biol Trace Elem Res

authors

Gupta T,Talukder G,Sharma A

doi

10.1007/BF02990346

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

95-101

issue

2

eissn

0163-4984

issn

1559-0720

journal_volume

30

pub_type

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