Abstract：
:The aim of this study was to analyze the effect of high dietary Fe on liver antioxidant status in mice fed a corn-oil-enriched diet. Male Balb/c mice were fed for 3 wk with a standard diet enriched with 5% by weight of corn oil with adequate Fe (FCO diet) or supplemented with 1% carbonyl Fe (FCOFe diet). The control group was fed a standard diet. The high-Fe diet induced a twofold increase of hepatic Fe level. However, an increase of thymic Fe level has been induced solely by dietary fat. The hepatic copper (Cu) level slightly decreased in the FCO diet. In the spleen, the high-Fe diet-induced increase of Fe level was negatively correlated with the Cu level. The antioxidant status was influenced by both dietary fat and Fe. Mice fed corn-oil-enriched diets had a higher concentration of thiobarbituric acid-reactive substances (TBARS), with a greater increase in the FCOFe diet. Fatty acid analysis showed decreased n-3 and n-6/n-3 ratio, particularly in the FCOFe diet. Hepatic Cu/Zn superoxide dismutase (CuZn-SOD) activity was decreased in FCO diet, and Fe supplementation caused a further decrease in the enzyme activity. These results suggest that feeding with corn oil-enriched diet increases oxidative damage by decreasing antioxidant enzyme defense. The high-Fe diet additionally affects the antioxidant defense system, further increasing the tissue's susceptibility to lipid peroxidation. Additionally, both corn-oil- and Fe-enriched diets have increased the Cu requirement in mice.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Domitrović R,Tota M,Milin Cdoi
10.1385/BTER:113:2:177subject
Has Abstractpub_date
2006-11-01 00:00:00pages
177-91issue
2eissn
0163-4984issn
1559-0720pii
BTER:113:2:177journal_volume
113pub_type
杂志文章abstract：:This study aims to reduce embryonic mortality, increase body weight, and improve immune system in chicken. A total of 240 eggs were assigned to three treatments (n = 60) and injected with cooper (Cu), zinc (Zn), and iron (Fe) loaded by montmorillonite (Mnt), and one untreated group (n = 60). Some hormones and enzymes ...
journal_title：Biological trace element research
pub_type： 杂志文章
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journal_title：Biological trace element research
pub_type： 杂志文章
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更新日期：2021-01-26 00:00:00
abstract：:A radioecological survey in Antarctica shows that the 239 + 240Pu, 238Pu, 241Am, 90Sr, and 137Cs activities were detectable in nearly all the samples. The activity level of 239 + 240Pu, 241Am, and 137Cs in antarctic sediments was about 5-20 times lower than in the northern Adriatic Sea sediments, but the 238Pu activit...
journal_title：Biological trace element research
pub_type： 杂志文章
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abstract：:Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patien...
journal_title：Biological trace element research
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更新日期：2014-06-01 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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更新日期：2010-04-01 00:00:00
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journal_title：Biological trace element research
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更新日期：1990-07-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2013-06-01 00:00:00
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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