Abstract:
:The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at day 14 postinoculation, survival was 58% in the Se-treated group as compared to 25% in the untreated group. Whole-blood glutathione peroxidase (GSH-Px) activity was elevated by 68% (p < 0.001) and Se content in the liver by 24% (p < 0.001). Red (RBC) and white blood cell (WBC) counts, as well as the number of cells in the spleen and thymus, were unaffected. The cellular counts of T-lymphocytes (CD4+, CD8+) and natural killer (NK+) cells in the blood were not affected. However, the CD4+/CD8+ ratio (5.2) tended to increase after Se supplementation (5.9). The spleen lymphoproliferative response to T- and B-cell mitogens were increased by 9 and 43%, respectively (ns), in the Se-supplemented group. The total NK cell activity in blood and spleen showed minor increases, but when the activity in the blood was expressed per cell, the increase amounted to 35% (ns) with Se supplementation. The inflammatory and necrotic lesions in the ventricular myocardium at 7 and 14 d postinoculation were not significantly reduced by Se treatment, probably owing to the increased survival with Se even of mice with the most pronounced heart damage; comparable untreated mice were estimated to have died at day 14. Results indicate that modest doses of Se can improve immune function, which may increase the general resistance to this viral infection.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Ilbäck NG,Fohlman J,Friman Gdoi
10.1007/BF02785277subject
Has Abstractpub_date
1998-07-01 00:00:00pages
51-66issue
1eissn
0163-4984issn
1559-0720journal_volume
63pub_type
杂志文章abstract::Zinc is an essential micronutrient for the organism and is critical for the functional and structural integrity of cells. Determination of the amount of trace element concentrations in tissues such as hair samples have been used for the evaluation of the metabolic status especially in children. Unlike serum zinc, conc...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02115-w
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journal_title:Biological trace element research
pub_type: 杂志文章,评审
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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abstract::The effects of nano-TiO2 (rutile) on the photochemical reaction of chloroplasts of spinach were studied. The results showed that when spinach was treated with 0.25% nano-TiO2, the Hill reaction, such as the reduction rate of FeCy, and the rate of evolution oxygen of chloroplasts was accelerated and noncyclic photophos...
journal_title:Biological trace element research
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abstract::In order to study the mechanisms underlying the effects of TiO(2) nanoparticles on lactate dehydrogenase (LDH, EC1.1.1.27), Institute of Cancer Research region mice were injected with nanoparticulate anatase TiO(2) (5 nm) of various doses into the abdominal cavity daily for 14 days. We then examined LDH activity in vi...
journal_title:Biological trace element research
pub_type: 杂志文章
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02191-y
更新日期:2021-02-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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abstract::Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determ...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
abstract::In the present world, X-rays have been regarded as one of the most efficient tools in medicine, industry and research. On the contrary, extensive human exposure to these rays is responsible for causing detrimental effects on physiological system. The aim of the present study was to investigate the role of zinc (Zn), i...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-0976-4
更新日期:2017-10-01 00:00:00
abstract::Several studies have investigated the relationship between serum and hair nickel (Ni) concentration and breast cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum and hair nickel levels and breast cancer. Nine studies determining...
journal_title:Biological trace element research
pub_type: 杂志文章,meta分析,评审
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journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789141
更新日期:1990-01-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02863080
更新日期:1991-02-01 00:00:00
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journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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更新日期:2012-10-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784001
更新日期:1992-04-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02778196
更新日期:1997-05-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:1980-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00