Abstract：
:Strontium stimulates cartilage matrix formation in vitro. However, the mechanisms governing these effects have not yet been extensively reported. In this study, chondrocytes were isolated from rat articular cartilage by enzymatic digestion and cultured for 24-72 h with 1-5 mM strontium. We investigated the effects of different concentrations of strontium on collagen content, type II collagen, insulin-like growth factor (IGF-1) and matrix metalloproteinase (MMP)-13 expression in rat cultured articular chondrocytes in vitro. The collagen content of the chondrocytes, determined as hydroxyproline, was measured by a colorimetry method. Type II collagen, IGF-1, and MMP-13 mRNA abundance and protein expression levels were determined by real-time polymerase chain reaction (real-time PCR) and western blot, respectively. The results showed that collagen content from the chondrocytes extracellular matrix increased with increasing strontium concentration. Moreover, 3 and 5 mM strontium strongly stimulated protein expression and mRNA levels of type II collagen and IGF-1. Conversely, MMP-13 expression in chondrocytes decreased dose-dependently with increasing strontium concentration. These results should provide insight into the ability of strontium to promote chondrocyte extracellular matrix synthesis. Strontium could promote collagen synthesis and suppress collagen degradation via the repression of MMP-13 expression.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Wang J,Zhu X,Liu L,Shi X,Yin L,Zhang Y,Li X,Wang Z,Liu Gdoi
10.1007/s12011-013-9640-9subject
Has Abstractpub_date
2013-06-01 00:00:00pages
212-9issue
1-3eissn
0163-4984issn
1559-0720journal_volume
153pub_type
杂志文章abstract：:This study aims to examine the effect of zinc supplementation on free-radical formation and antioxidant system in individuals who are actively engaged in wrestling as a sport. The study registered a total of 40 male subjects, of whom 20 were wrestlers and 20 were sedentary individuals. The subjects were equally alloca...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8457-z
更新日期：2010-04-01 00:00:00
abstract：:Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796667
更新日期：1987-04-01 00:00:00
abstract：:Two organoselenium compounds: xylitol selenious ester (xylitol-Se) and sucrose selenious ester (sucrose-Se) were synthesized, and their molecular structures were characterized in this study. In MTT assay, xylitol-Se and sucrose-Se showed cytostatic effects on human hepatocellular carcinoma cells SMMC-7221 in a dose-de...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9715-7
更新日期：2013-08-01 00:00:00
abstract：:The present study aimed to investigate the prevalence of thrombocytopenia and its association with serum magnesium in a nationally representative cohort. A total of 8478 participants aged 18 years and over were recruited in a cross-sectional survey. Thrombocytopenia was defined as platelet count less than 150 × 10(9)/...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0406-4
更新日期：2016-01-01 00:00:00
abstract：:This experiment was conducted to evaluate the effects of zinc (ZnSO4.H2O) and vitamin A (retinol) supplementation on performance, carcass characteristics, and serum concentrations of glucose, cholesterol, total protein, and malondialdehyde (MDA) as an indicator of lipid peroxidation in broiler chickens (Ross) reared a...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1385/BTER:94:3:225
更新日期：2003-09-01 00:00:00
abstract：:The present study was conducted to investigate whether the combined treatment with Se and Zn offers more beneficial effects than that provided by either of them alone in reversing Cd-induced oxidative stress in the kidney of rat. For this purpose, 30 adult male Wistar albino rats, equally divided into control and four...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8324-y
更新日期：2009-08-01 00:00:00
abstract：:Naphthalene-1-acetic acid (HNAA), dichlorophenoxy acetic acid (HDAA), and indole-3-acetic acid (HIAA) are auxinhormones that can affect the growth of plants. The lanthanide complexes of the above auxinhormone LnA3 x 3H2O (Ln = La3+, Ce3+, Sm3+, Er3+, Yb3+; HA = HNAA, HDAA, HIAA; A = NAA-, DAA-, IAA-) were synthesized ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783322
更新日期：1998-07-01 00:00:00
abstract：:The movement of copper and zinc from the fertilized egg into the developing embryo and the subsequent association of the two metals with metallothionein-like proteins (MT) of chick liver was investigated. Hepatic levels of MT in 1-d-old chicks, estimated from specifically bound(115m)Cd, were increased eightfold over e...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02988942
更新日期：1983-12-01 00:00:00
abstract：:Zinc is an essential micronutrient for the organism and is critical for the functional and structural integrity of cells. Determination of the amount of trace element concentrations in tissues such as hair samples have been used for the evaluation of the metabolic status especially in children. Unlike serum zinc, conc...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02115-w
更新日期：2020-08-01 00:00:00
abstract：:It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783183
更新日期：1993-11-01 00:00:00
abstract：:Inducing the differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) proceeds with low efficiency, which greatly limits clinical applications. Divalent metal elements play an important role in osteoinductivity for bone remodeling because they can simulate bone formation and decrease bone resorption...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1256-7
更新日期：2018-10-01 00:00:00
abstract：:In brain, excess zinc alters the metabolism of amyloid precursor protein, leading to β-amyloid protein deposition, one of the hallmarks of Alzheimer's disease (AD) pathology. Recently, it has been reported that zinc accelerates in vitro tau fibrillization, another hallmark of AD. In the current study, we examined the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9411-z
更新日期：2012-11-01 00:00:00
abstract：:This in vitro study was designed to assess the impact of divalent (Fe(2+)) or trivalent (Fe(3+)) iron on the activity and oxidative balance of bovine spermatozoa at specific time intervals (0, 2, 8, 16, and 24 h) during an in vitro culture. Forty-five semen samples were collected from adult breeding bulls and diluted ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0288-5
更新日期：2015-09-01 00:00:00
abstract：:The current information about the effect of physical exercise on the body concentrations of several minerals is still limited, both in the acute (short-term) and adaptive (long-term) responses. So, this manuscript aims, on the one hand, to assess the possible differences on basal levels of cobalt (Co), copper (Cu), an...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-018-1500-1
更新日期：2019-06-01 00:00:00
abstract：:Measurement and monitoring of magnesium (Mg) are important to prevent the development of serious and potentially fatal complications in critically ill patients. Although ion-selective electrodes are available and earlier reports suggest that free ionized magnesium (iMg2+) is the most useful test to estimate Mg status,...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:115:1:13
更新日期：2007-01-01 00:00:00
abstract：:After considering the need for quality control in NAA, the concept of quality in NAA procedures themselves is discussed, and some important factors identified. Two approaches to improve quality are then described in more detail. The first concerns the unique ability of NAA using different isotopic reactions and differ...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02917356
更新日期：1994-10-01 00:00:00
abstract：:Auxiliary enzymes participate in β-oxidation of unsaturated fatty acids. The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Δ(3)Δ(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues. Five groups of eight weanling rats each were fed...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9940-8
更新日期：2014-06-01 00:00:00
abstract：:A 6-week trial was conducted to compare the effect of selenium (Se) from hydroponically produced Se-enriched kale sprout (HPSeKS), sodium selenite (SS), and Se-enriched yeast (SeY) in laying hens. A total of 144 40-week-old hens were randomly divided into four groups, according to a completely randomized design. Each ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1069-0
更新日期：2018-03-01 00:00:00
abstract：:The effects of environmental lead on the immune system of young children were assessed by determining the peripheral blood lymphocytes CD3+, CD4+, CD8+, B(CD19+) counts, and natural killer (CD16+CD56+) cells in 35 preschool children whose mean blood lead level was 140.6 microg/L. The results were compared to an age- a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:105:1-3:019
更新日期：2005-07-01 00:00:00
abstract：:Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective functions cannot be solely attributed to the action of glutathione peroxidase. Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stres...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/BF02783992
更新日期：1992-04-01 00:00:00
abstract：:According to undiscovered toxicity and safety of magnesium oxide nanoparticles (MgO NPs) in isolated pancreatic islet cells, this study was designed to examine the effects of its various concentrations on a time-course basis on the oxidative stress, viability, and function of isolated islets of rat's pancreas. Pancrea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0754-8
更新日期：2017-01-01 00:00:00
abstract：:Cadmium (Cd) pollution and acid rain are the main environmental issues, and they often occur in the same agricultural region. Nevertheless, up to now, little information on the combined pollution of Cd(2+) and acid rain action on crops were presented. Here, we investigated the combined effect of Cd(2+) and acid rain o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9053-6
更新日期：2011-12-01 00:00:00
abstract：:Descriptions of the effects of paraquat (P2+) on the peroxidation of liver microsomes are very divergent. Therefore, the presence of ferric iron in the medium and the activity of microsomal mixed-function oxidase system are two factors that we have taken into consideration to explain the discrepancies. The results sho...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02790096
更新日期：1995-01-01 00:00:00
abstract：:This study was performed to assess how 4 weeks of magnesium supplementation and exercise affect the free and total plasma testosterone levels of sportsmen practicing tae kwon do and sedentary controls at rest and after exhaustion. The testosterone levels were determined at four different periods: resting before supple...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8676-3
更新日期：2011-04-01 00:00:00
abstract：:The metabolic thermograms and heat output of mitochondria isolated from carp liver have been determined by using an LKB bioactivity monitor. The thermogram can be divided into four parts: the lag phase, active recovery phase, stationary phase, and decline phase. The thermokinetic equation was established for the activ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783314
更新日期：1997-10-01 00:00:00
abstract：:Magnesium (Mg) concentrations in diets have been associated with performance and eggshell quality of laying hens, but the results have been inconclusive. In this experiment, the effects of increasing concentrations of dietary Mg on productive performance and eggshell quality of aged laying hens were evaluated. A total...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9537-z
更新日期：2013-01-01 00:00:00
abstract：:This study examined the effects of dietary (2.0 ppm for 8 wk) and in vitro (1 x 10(-7)M) supplementation with selenium (Se, as sodium selenite) on the activity of spleen natural killer (NK) cells and plastic-adherent lymphokine-activated killer (A-LAK) cells from C57B1/6J male mice. Dietary supplementation with Se res...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789164
更新日期：1996-06-01 00:00:00
abstract：:Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992691
更新日期：1990-07-01 00:00:00
abstract：:Ferritin levels have been associated with metabolic syndrome and insulin resistance. The aim of the present study was to evaluate the prediction of ferritin levels by variables related to cardiometabolic disease risk in a multivariate analysis. For this aim, 123 healthy women (72 premenopausal and 51 posmenopausal) we...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9351-7
更新日期：2012-08-01 00:00:00
abstract：:Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02402-6
更新日期：2020-10-06 00:00:00
