Abstract：
:It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than mutant males. Furthermore, 6-8-d-old or 3-4-wk-old mutant males were more sensitive to copper-induced toxicity than 8-9-wk-old mutant males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in mutant females. On the other hand, in the case of normal mice, the sensitivity in 6-8-d-old or 3-4-wk-old mice to copper-induced toxicity was not also affected by sex. In contrast to mutant, however, 8-9-wk-old normal males were more sensitive to copper-induced toxicity than 8-9-wk-old normal females. Adult males were also more sensitive to copper-induced toxicity than 6-8-d-old or 3-4-wk-old males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in normal females. These results indicate that sex- and age-related differences in the copper-induced toxicity exist in macular mutant mice.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Shiraishi N,Taguchi T,Kinebuchi Hdoi
10.1007/BF02783183subject
Has Abstractpub_date
1993-11-01 00:00:00pages
129-37issue
2-3eissn
0163-4984issn
1559-0720journal_volume
39pub_type
杂志文章abstract：:The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9834-1
更新日期：2013-12-01 00:00:00
abstract：:The objective was to evaluate metal ion accumulation in hair of patients undergoing orthodontic treatment with fixed appliances in time. The patients (N = 47) participated in a questionnaire survey. Hair sampling was performed at the beginning and in the 4th, 8th, and 12th month of the treatment. The content of metals...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-014-0152-z
更新日期：2015-02-01 00:00:00
abstract：:The k0 standardization method was adapted for NAA with stable low-flux reactors where flux monitors are not needed. The modified k0 method offers the convenience of the use of libraries of sensitivity constants. It was compared to the relative method for 52 elements using a SLOWPOKE reactor and 6 counting geometries. ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784232
更新日期：1999-01-01 00:00:00
abstract：:Few studies have evaluated the biomarker changes of fluoride exposure. In order to explore early and sensitive indicators, animal experiment was designed. Ninety-six healthy SD rats (48 males and 48 females) weighing approximately 60 g were randomly divided into six groups of 16 animals each by gender average. Control...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0034-4
更新日期：2014-07-01 00:00:00
abstract：:Animal feed has traditionally been supplemented with trace elements at dietary concentrations well above physiological needs. However, environmental concerns have led to calls for better adjustment of mineral supplementation to actual physiological needs and, in this context, consideration of breed-related differences...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1276-3
更新日期：2018-11-01 00:00:00
abstract：:Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for diabetic foot ulcer (DFU). This study was carried out to evaluate the effects of magnesium administration on wound healing and metabolic status in subjects with DFU. This randomized, doubl...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-017-1056-5
更新日期：2018-02-01 00:00:00
abstract：:The incorporation of(3)H-thymidine into DNA in the brains of the 17-day and 20-day old rat fetuses was significantly reduced by maternal zinc restriction during pregnancy. The activity of the enzyme thymidine kinase (EC 2.7.1.21) was similarly reduced in the zine-deprived fetal brains on days 14 and 20 of gestation, b...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789032
更新日期：1980-03-01 00:00:00
abstract：:We investigated the effect of magnesium supplementation on zinc distribution in rats given excess calcium as carbonate. Rats were given a control diet (5 g/kg calcium and 0.5 g/kg magnesium), a high calcium diet (HC, 25 g/kg calcium and 0.5 g/kg magnesium) or the high calcium diet supplied with magnesium (HCM, 25 g/kg...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8166-z
更新日期：2008-11-01 00:00:00
abstract：:The primary aim of the research was to assess the level of trace elements and electrolytes in serum of postmenopausal diabetic women. Sixty-four postmenopausal women with type 2 diabetes mellitus (DM2) and 64 age- and body mass index-matched controls were examined. Serum trace elements were assessed using inductively ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-016-0868-z
更新日期：2017-05-01 00:00:00
abstract：:Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators ...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-012-9487-5
更新日期：2012-12-01 00:00:00
abstract：:Selenium is an important nutrient for humans and livestock. Soil selenium concentration in the world is highly variable; deficiency and toxicity occur in populations living short distance apart. Knowledge of Se concentrations in humans and the environments, especially because the range for toxicity and deficiency is n...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1489-5
更新日期：2019-06-01 00:00:00
abstract：:In brain, excess zinc alters the metabolism of amyloid precursor protein, leading to β-amyloid protein deposition, one of the hallmarks of Alzheimer's disease (AD) pathology. Recently, it has been reported that zinc accelerates in vitro tau fibrillization, another hallmark of AD. In the current study, we examined the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9411-z
更新日期：2012-11-01 00:00:00
abstract：:The toxic effect of Pb2+ has been studied in eukaryotic cells by using Tetrahymena as a target. The maximum power (P(m)) and the growth rate constant (k) were determined, which showed that values of P(m) and k were linked to the concentration (C) of Pb2+. The addition of Pb2+ caused a decrease of the maximum heat prod...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-0055-3
更新日期：2007-11-01 00:00:00
abstract：:Hexavalent chromium (Cr(VI)) is present in the marine environment and is a known carcinogen and reproductive toxicant. Cr(VI) is the form of chromium that is well absorbed through the cell membrane. It is also the most prevalent form in seawater. We measured the total Cr levels in skin biopsies obtained from healthy f...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0311-x
更新日期：2015-07-01 00:00:00
abstract：:Zinc absorption from the alimentary tract, as revealed by serum zinc concentration, was studied in a group of 10 patients (age 37.7+/-5.1 yr) with moderate and severe untreated primary arterial hypertension before and after a 30-d treatment with perindopril 4 mg/d. Blood pressure was 177.33+/-16.24/111.33+/-15.26 mm H...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:83:1:31
更新日期：2001-10-01 00:00:00
abstract：:The effects of cerium oxide nanoparticles on the proliferation, differentiation, and mineralization function of primary osteoblasts in vitro were evaluated. The results showed that the cell biological effects of cerium oxide nanoparticles varied with different diameters. The cytotoxicity of cerium oxide nanoparticles ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9655-2
更新日期：2013-06-01 00:00:00
abstract：:Nutritional profile of minerals and antioxidants in Indian spice extracts was evaluated in order to examine their efficacy in treating various diseases, disorders, and allergies in human health. Extracts of four medicinal plants such as Curcuma longa, Zingiber officinale, Piper nigrum, and Piper longum, regularly cons...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02228-2
更新日期：2021-03-01 00:00:00
abstract：:Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0117-2
更新日期：2014-12-01 00:00:00
abstract：:The onset of Alzheimer's disease has been shown to affect trace element concentrations in the brain when compared to "normal" subjects in ex vivo samples. The techniques used to determine trace element concentrations were proton-induced X-ray emission and instrumental neutron activation analysis. With these methods, s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784242
更新日期：1999-01-01 00:00:00
abstract：:This study was performed to investigate calcium (Ca), inorganic phosphorus (P), potassium (K), magnesium (Mg), and chlorine (Cl) levels in blood serum at d 60, 100, and 150 of gestation and at d 45 after parturition and to find out the significance of differences for macromineral levels during these stages of single o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:107:3:247
更新日期：2005-12-01 00:00:00
abstract：:The interaction of VO2+ with the muchopolysaccharide chondroitin sulfate A (CSA) has been investigated by electron absorption spectroscopy and infrared measurements in aqueous solutions at different pH-values and ligand to metal ratios up to 6:1. The generation of a VO(CSA)2 species could be demonstrated. Coordination...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990487
更新日期：1994-07-01 00:00:00
abstract：:This study was aimed to assess the protective effect of sodium selenite on the ileum mucosal immunologic injury induced by AFB1. One hundred eighty-one-day-old healthy male Avian broilers were divided into four groups of three replicates and 15 birds per replicate and fed with basal diet (control group), 0.3 mg/kg AFB...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0035-3
更新日期：2014-07-01 00:00:00
abstract：:Elemental concentrations in head hair and blood (whole-blood, erythrocytes and plasma) of 28 Nigerian subjects were determined using instrumental neutron activation analysis (INAA) and proton-induced X-ray emission (PIXE) techniques. Correlations found between different elements in hair and blood are reported. Hair le...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/BF02917347
更新日期：1994-10-01 00:00:00
abstract：:Arsenic (As) is widely distributed in our living environment and is useful for industry, agriculture, medical treatment, and other fields. Arsenic trioxide (As2O3) is an existing form of As. Exposure to As2O3 has a toxic effect on humans and animals. It not only leads to skin cancer, peripheral vascular disease, hyper...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0462-9
更新日期：2016-03-01 00:00:00
abstract：:Two 42-d experiments were conducted with weanling male rats to study interactions between nickel and copper. In Experiment 1, a low-copper basal diet was supplemented with copper at 0 or 30 ppm and nickel at 0 or 30 ppm. Copper was added in Experiment 2 to a basal copper-deficient diet at a level of 0 or 15 ppm and ni...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916540
更新日期：1985-04-01 00:00:00
abstract：:Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expres...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0282-y
更新日期：2015-09-01 00:00:00
abstract：:An experimental study was conducted in Wistar rats to characterize the arsenic ("As")-induced alterations in neurobiochemistry in brain and its impact on neuropharmacological activities with or without the melatonin (MLT) as an antioxidant given exogenously. Male Wistar rats were randomly divided in to four groups of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1537-1
更新日期：2019-07-01 00:00:00
abstract：:Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1371-5
更新日期：2019-01-01 00:00:00
abstract：:The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at day 14 postinoculation, survival was 58% in the Se-treated grou...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02785277
更新日期：1998-07-01 00:00:00
abstract：:Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8894-8
更新日期：2011-11-01 00:00:00
