Abstract:
:Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethionine, or a yeast-derived selenium supplement. A p value cutoff of 0.01 was used to identify a select set of selenium-responsive genes that were consistently differentially expressed across three age groups of mice with both ANOVA and t test analyses. A total of 19 gene transcripts were found to be differentially expressed across the three age groups with at least one selenium-deficient/selenium-supplemented diet comparison. Of those 19 genes, 12 had been previously identified as selenoprotein-encoding genes, and four of the genes, Gpx1, Selh, Sep15, and Sepw1, were differentially expressed in both tissues, all three mouse age groups, and all three diet comparisons. Activities associated with non-selenoproteins encoded by selenium-responsive genes included transport and stress response. The selenophosphate synthetase 2 gene Sephs2 in gastrocnemius tissue and the solute carrier gene Slc48a1 in liver tissue, both up-regulated with selenium-deficient diets compared to all three selenium-supplemented diets, are previously overlooked candidates for dietary selenium marker genes.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Mallonee DH,Crowdus CA,Barger JL,Dawson KA,Power RFdoi
10.1007/s12011-010-8894-8subject
Has Abstractpub_date
2011-11-01 00:00:00pages
992-1006issue
2eissn
0163-4984issn
1559-0720journal_volume
143pub_type
杂志文章abstract:UNLABELLED:Limited data are available indicating the effects of chromium administration on endocrine profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). This study was done to assess the effects of chromium administration on endocrine profiles, biomarkers of inf...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-015-0570-6
更新日期:2016-07-01 00:00:00
abstract::The effects of cobaltous chloride in inducing chromosomal aberrations were observed on laboratory bred mice in vivo after single oral administration of different fractions (1/10, 1/20, 1/40) of the lethal toxic dose of the salt. Bone marrow cells were flushed out and processed for chromosome studies following colchici...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF03032691
更新日期:1991-05-01 00:00:00
abstract::Magnesium (Mg) concentrations in diets have been associated with performance and eggshell quality of laying hens, but the results have been inconclusive. In this experiment, the effects of increasing concentrations of dietary Mg on productive performance and eggshell quality of aged laying hens were evaluated. A total...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9537-z
更新日期:2013-01-01 00:00:00
abstract::The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antituberculosis therapy. Copper (Cu), zinc (Zn), and sel...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/BTER:95:1:65
更新日期:2003-10-01 00:00:00
abstract::The variance of testing was compared between the College of American Pathologists clinical survey and that of a recent review about hair mineral testing. The review suggested that the accuracy of hair mineral testing was unreliable. In general, there was a greater range of variance in the College of American Pathologi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:87:1-3:001
更新日期:2002-07-01 00:00:00
abstract::The authors present a simple and rapid method for assaying ultrafilterable copper (Cu UF) and albumin-bound copper (Cu ALB). It is based on the ultrafiltration of serum in the presence of ethylenediaminetetraacetic acid (EDTA), used to prevent adsorption on the membranes. EDTA at 0.4 g/L has no effect on the equilibri...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02917499
更新日期:1988-12-01 00:00:00
abstract::An in vitro system employing collagen isolated from the sheep tendons to induce mineralization and demineralization reactions was used not only to study the effect of various concentrations of fluoride on the collagen-induced mineralization and demineralization reactions but also to compare their action with the inhib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02340-3
更新日期:2020-08-27 00:00:00
abstract::A microcomputer-controlled irradiation and measurement system and a microprocessor-controlled sample changer have been installed at the SLOWPOKE-2 Facility at the Royal Military College of Canada (RMC). These systems can provide the gamut of instrumental neutron activation analysis (INAA) techniques for the analyst. C...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992658
更新日期:1990-07-01 00:00:00
abstract::The main aim of the study was to determine the role of cerium in the amelioration of calcium-deficiency effects in spinach plants. Spinach plants were cultivated in Hoagland's solution. They were subjected to calcium-deficiency and to cerium chloride administered in the calcium-present Hoagland's media and calcium-def...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8054-y
更新日期:2008-03-01 00:00:00
abstract::The concentrations of 7 metals (lead, cadmium, manganese, copper, nickel, silver, and chromium) were determined in 32 different species of wild mushrooms. The mushroom samples, which have been using for food and some medical purposes, were collected from Konya, an Inner Anatolian region of Turkey. The highest metal co...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:110:1:79
更新日期:2006-04-01 00:00:00
abstract::In the article, we report that effects of nano-anatase on the spectral characteristics and content of light-harvesting complex II (LHCII) on the thylakoid membranes of spinach were investigated. The results showed that nano-anatase treatment could increase LHCII content on the thylakoid membranes of spinach and the tr...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8025-3
更新日期:2007-01-01 00:00:00
abstract::The onset of Alzheimer's disease has been shown to affect trace element concentrations in the brain when compared to "normal" subjects in ex vivo samples. The techniques used to determine trace element concentrations were proton-induced X-ray emission and instrumental neutron activation analysis. With these methods, s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784242
更新日期:1999-01-01 00:00:00
abstract::Three-month studies were performed on 18 adult rabbits of New Zealand breed divided into three groups, with six animals in each: a control group on standard diet, a cholesterol group receiving 500 mg of cholesterol/100 g of feed per rabbit per 24 h (CH group), and a cholesterol + fluorine group (CH + F group) receivin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8129-4
更新日期:2008-08-01 00:00:00
abstract::The influence of hair color on the trace elemental status in horse's hair has been studied. A current analytical technique such as particle-induced X-ray emission (PIXE) used in this study has provided reliable, rapid, easy, and relatively inexpensive diagnostic methods. Twenty-eight elements (Al, Br, Ca, Cl, Co, Cu, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:103:2:169
更新日期:2005-02-01 00:00:00
abstract::Previous studies revealed that Se was an important regulatory factor for glutathione peroxidase (GPx) genes. However, the relationship between Se concentrations and mRNA expression levels of GPxs were unclear in goats, especially the goats living in natural Se-enriched area. Thus, the aim of this study was to determin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9830-5
更新日期:2013-12-01 00:00:00
abstract::Linolenic acid is an inhibitor of electron transport in chloroplasts of higher plants. It has obvious effects on the structure and function of chloroplasts. In the present paper, we investigated the nano-anatase relieving the inhibition of photoreduction activity and oxygen evolution caused by linolenic acid in spinac...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-8055-x
更新日期:2008-04-01 00:00:00
abstract::Daily ingestion of lead (Pb), even through piped drinking water, has long time been an important issue of concern, attracting for decades research in environmental science and toxicology, and again comes to prominence because of recent high-profile cases of exposure of populations in several countries to Pb-contaminat...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-018-1336-8
更新日期:2018-12-01 00:00:00
abstract::The liver of Hooded Seal (Cystophora cristata) consists of six lobes of unequal sizes. Extensive sampling by means of cutout samples covering the depth horizon 2-30 mm below liver surface indicates that the liver may be considered homogeneous as to concentrations of zinc, cadmium, mercury, and selenium (residuals of o...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789141
更新日期:1990-01-01 00:00:00
abstract::Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8824-9
更新日期:2011-09-01 00:00:00
abstract::Cadmium concentrations were determined in the hair of 226 school children in an industrial and in a rural area of Tarragona Province (NE Spain). The influence of sex, age, hair color, smoking habits of the household members, and parents' occupation on the children's hair cadmium levels was also evaluated. Children liv...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02863080
更新日期:1991-02-01 00:00:00
abstract::Manganese (Mn) is an essential element for normal development and bodily functions in humans. In the present study, we examined whether Mn supplementation can alter the serum lipid parameters and liver function in Ca-deficient ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats (6 weeks) were divided into five...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-010-8714-1
更新日期:2011-06-01 00:00:00
abstract::Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992691
更新日期:1990-07-01 00:00:00
abstract::Environmental metal exposure, as well as dietary metals, may adversely affect semen quality even as others play an essential role in normal spermatogenesis and fertility. Measures of seminal fluid metals have therefore been of high interest in the last several decades but have shown inconsistent results in correlation...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1527-3
更新日期:2019-07-01 00:00:00
abstract::Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02468-2
更新日期:2020-11-05 00:00:00
abstract::Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783852
更新日期:1999-11-01 00:00:00
abstract::Human ocular tissues from 50 donor eyes were elementally and morphologically analyzed in order to correlate the elemental content and distribution of Ca, Ba, Cr, Cu, Zn, and Se with ocular morphology, sex, race, irideal pigmentation, age, time of death, birth weight, presence and severity of diabetes, and other pathol...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02796667
更新日期:1987-04-01 00:00:00
abstract::Exposure to ionizing total-body radiation suppresses hematopoiesis, resulting in decreased production of blood cells. Many researchers have demonstrated the critical role of zinc (Zn) in diverse physiological processes, such as growth and development, maintenance and priming of the immune system, and tissue repair. Th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:100:1:063
更新日期:2004-07-01 00:00:00
abstract::The chronic exposure to Aluminum (Al) may compromise different liver functions, mainly during the hepatic regeneration. The aim of this study is to investigate the interactions between the chronic i.p. exposure to Al and hepatic regeneration (HR) on bile flow and organic anion transport in experimental animals. For th...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8234-4
更新日期:2009-02-01 00:00:00
abstract::Smoking is one of the major causes of mortality and numerous diseases, both directly and indirectly. The role of smoking as a significant risk factor is already known in several human diseases such as cardiovascular diseases, lung cancer, and chronic obstructive pulmonary disease. We aimed to compare the toxicity of h...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02537-6
更新日期:2021-01-20 00:00:00
abstract::Divalent metal ions (Fe2+, Cu2+, Zn2+, Ni2+, and Mn2+) induced lipid oxidation in cooked, but not in raw fish. The extent of lipid oxidation, measured by the production of thiobarbituric acid reactive substances (TBRS), was increased with higher concentrations of iron, zinc, and nickel, but was decreased with increasi...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783896
更新日期:1992-07-01 00:00:00