The interactions between the chronic exposure to Aluminum and liver regeneration on bile flow and organic anion transport in rats.


:The chronic exposure to Aluminum (Al) may compromise different liver functions, mainly during the hepatic regeneration. The aim of this study is to investigate the interactions between the chronic i.p. exposure to Al and hepatic regeneration (HR) on bile flow and organic anion transport in experimental animals. For this purpose, we studied bile flow and fractional transfer rates for the transport of hepatic organic anions (hepatic uptake, sinusoidal efflux, and canalicular excretion), as well as parameters related with the oxidative stress (OS), on rats chronically treated with Al at 0 and 2 days of HR. The Al treatment and time of HR caused a decrease in the biliary flow and in the hepatic uptake and canalicular excretion constants. In addition, Al and HR increased the lipoperoxidation associated with a reduction of the glutathione content and glutathione peroxidase and catalase enzyme's activities. Since the effects of Al and HR on biliary flow and transport systems were additive, but not on the oxidative status, different mechanisms might be involved on these alterations. Even though the OS may play a key role on the hepatic deleterious effects, there is no unique cause-effect relationship between OS and liver dysfunction in this experimental animal model.


Biol Trace Elem Res


González MA,Bernal CA,Mahieu S,Carrillo MC




Has Abstract


2009-02-01 00:00:00












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    abstract::In the article, we report that effects of nano-anatase on the spectral characteristics and content of light-harvesting complex II (LHCII) on the thylakoid membranes of spinach were investigated. The results showed that nano-anatase treatment could increase LHCII content on the thylakoid membranes of spinach and the tr...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Zheng L,Su M,Wu X,Liu C,Qu C,Chen L,Huang H,Liu X,Hong F

    更新日期:2007-01-01 00:00:00

  • Cigarette smoking and hyperglycemia increase renal response to low levels of cadmium in welders: cystatin C as a sensitive marker.

    abstract::The present study was undertaken to investigate the utility of cystatin C (CysC) as an early biomarker of cadmium (Cd)-induced renal injury. The study was carried out on 50 adult male individuals divided into five groups of 10 individuals as follows: control, welders, smoker welders, diabetic welders, and smoker diabe...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Harisa GI,Attia SM,Ashour AE,Abdallah GM,Omran GA,Touliabah HE

    更新日期:2014-06-01 00:00:00

  • Monitoring metals in the population living in the vicinity of a hazardous waste incinerator: levels in hair of school children.

    abstract::Hair samples of 134 school children (12-14 yr old) living in three residential zones in the vicinity of a new hazardous waste incinerator (HWI) (Constanti, Tarragona County, Catalonia, Spain) were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) for arsenic (As), beryllium (Be), cadmium (Cd), chromium...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Nadal M,Bocio A,Schuhmacher M,Domingo JL

    更新日期:2005-06-01 00:00:00

  • Study the Effect of Microinjection of Zn, Fe, and Cu Loaded in Montmorillonite on Development Activities in Fertilized Chicken Eggs.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Elokil A,Darwish AM,Wei J,Barakat IAH,Mahrous KF,El-Kaiaty A,Li S,Zoheir KMA

    更新日期:2020-11-13 00:00:00

  • Determination of Glutathione, Selenium, and Malondialdehyde in Different Edible Mushroom Species.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Dogan H,Coteli E,Karatas F

    更新日期:2016-12-01 00:00:00

  • Dose-Dependent Differential Effects of In Vivo Exposure of Cadmium on Myometrial Activity in Rats: Involvement of VDCC and Ca2+-Mimicking Pathways.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Saroj VK,Nakade UP,Sharma A,Choudhury S,Hajare SW,Garg SK

    更新日期:2018-02-01 00:00:00

  • Protective Effects of Dietary Garlic Powder Against Cadmium-induced Toxicity in Sea Bass Liver: a Chemical, Biochemical, and Transcriptomic Approach.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Mosbah A,Guerbej H,Boussetta H,Bouraoui Z,Banni M

    更新日期:2018-06-01 00:00:00

  • Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Shafik NM,Baalash A,Ebeid AM

    更新日期:2017-12-01 00:00:00

  • Effects of dietary combination of chromium and biotin on egg production, serum metabolites, and egg yolk mineral and cholesterol concentrations in heat-distressed laying quails.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Sahin K,Onderci M,Sahin N,Gursu MF,Vijaya J,Kucuk O

    更新日期:2004-11-01 00:00:00

  • Simple assay of serum copper fractions by ultrafiltration and flameless atomic absorption.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Favier A,Ruffieux D

    更新日期:1988-12-01 00:00:00

  • Natural variation in grain selenium concentration of wild barley, Hordeum spontaneum, populations from Israel.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Yan J,Wang F,Qin H,Chen G,Eviatar N,Fahima T,Cheng J

    更新日期:2011-09-01 00:00:00

  • Accumulation of calcium in human common iliac artery, aortic valve, xiphoid process, costal cartilage, posterior longitudinal ligament, trigeminal nerve, and rib accompanied by increase of magnesium.

    abstract::To examine whether an accumulation of Ca in the tissues was accompanied by an increase of Mg, the authors investigated the relationships between Ca and Mg contents in the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs by inducti...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Tohno Y,Tohno S,Azuma C,Moriwake Y,Utsumi M,Furuta K,Yamada M,Kumai T,Minami T,Takano Y

    更新日期:2004-01-01 00:00:00

  • Induction and characterization of metallothionein in different organs of Ostrea edulis L.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Alonso JI,Martin-Mateo MC

    更新日期:1996-07-01 00:00:00

  • Interaction of Lead with Calcium, Iron, and Zinc in the Biological Samples of Malnourished Children.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Talpur S,Afridi HI,Kazi TG,Talpur FN

    更新日期:2018-06-01 00:00:00

  • Inflammatory Factor Alterations in the Gastrointestinal Tract of Cocks Overexposed to Arsenic Trioxide.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Xing M,Zhao P,Guo G,Guo Y,Zhang K,Tian L,He Y,Chai H,Zhang W

    更新日期:2015-10-01 00:00:00

  • Effects of Nano-copper on Antioxidant Function in Copper-Deprived Guizhou Black Goats.

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    journal_title:Biological trace element research

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    authors: Shen X,Song C,Wu T

    更新日期:2020-08-18 00:00:00

  • The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Olszowski T,Gutowska I,Baranowska-Bosiacka I,Piotrowska K,Korbecki J,Kurzawski M,Chlubek D

    更新日期:2015-06-01 00:00:00

  • Effect of Chromium Supplementation on Performance, Carcass Characteristics, Blood Biochemistry, and Immune Response of Unstressed Broiler Chickens: a Dose-Response Meta-Analysis.

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    authors: Piray AH,Foroutanifar S

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  • Associations Between Copper and Zinc and Risk of Hypertension in US Adults.

    abstract::Evidence linking copper and zinc to hypertension are limited and conflicting. Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 were used. Zinc and copper intake from diet and supplements was assessed with 24-h dietary recall. Hypertension was defined as systolic blood pressure (SBP) ≥ ...

    journal_title:Biological trace element research

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    authors: Yao J,Hu P,Zhang D

    更新日期:2018-12-01 00:00:00

  • Analyses of impact of metal ion contamination on carp (Cyprinus carpio L.) gill cell suspensions.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Arabi M

    更新日期:2004-09-01 00:00:00

  • Interactive Effects of Copper Sources and a High Level of Phytase in Phosphorus-Deficient Diets on Growth Performance, Nutrient Digestibility, Tissue Mineral Concentrations, and Plasma Parameters in Nursery Pigs.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Ren P,Chen J,Hancock D,Vazquez-Añón M

    更新日期:2021-01-11 00:00:00

  • Do zinc and selenium prevent the antioxidant, hepatic and renal system impairment caused by aspirin in rats?

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Kesik V,Lenk MK,Kurekci AE,Acikel CH,Akgul EO,Aydin A,Erdem O,Gamsizkan M

    更新日期:2008-07-01 00:00:00

  • Effect of micronutrients on methylglyoxal-mediated in vitro glycation of albumin.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Tarwadi KV,Agte VV

    更新日期:2011-11-01 00:00:00

  • Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Banu H,Renuka N,Faheem SM,Ismail R,Singh V,Saadatmand Z,Khan SS,Narayanan K,Raheem A,Premkumar K,Vasanthakumar G

    更新日期:2018-11-01 00:00:00

  • Lipid peroxidation in rats administrated with mercuric chloride.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Huang YL,Cheng SL,Lin TH

    更新日期:1996-05-01 00:00:00

  • Protective effect of edible marine algae, Laminaria japonica and Porphyra haitanensis, on subchronic toxicity in rats induced by inorganic arsenic.

    abstract::Arsenic, a potent environmental toxic agent, causes various hazardous effects on human health. This study was performed to evaluate the protective effects of edible marine algae, Laminaria japonica and Porphyra haitanensis, on subchronic stress of rats induced by arsenic trioxide (As2O3). The co-treatment of marine al...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Jiang Y,Wang L,Yao L,Liu Z,Gao H

    更新日期:2013-09-01 00:00:00

  • Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of lebanese adults.

    abstract::Zinc, copper, and selenium statuses were reported to be linked to the development of chronic diseases, especially coronary heart disease (CHD). Metabolic syndrome, a known CHD risk factor, was found to be highly prevalent in Lebanon. Nevertheless, no data are available on the statuses of plasma zinc, copper, and selen...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Obeid O,Elfakhani M,Hlais S,Iskandar M,Batal M,Mouneimne Y,Adra N,Hwalla N

    更新日期:2008-07-01 00:00:00

  • Effect of lycopene against cisplatin-induced acute renal injury in rats: organic anion and cation transporters evaluation.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Erman F,Tuzcu M,Orhan C,Sahin N,Sahin K

    更新日期:2014-04-01 00:00:00

  • Lipid peroxidation in liver of mice administrated with nickel chloride: with special reference to trace elements and antioxidants.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Chen CY,Huang YL,Lin TH

    更新日期:1998-02-01 00:00:00

  • Relationship of Dietary and Serum Zinc with Depression Score in Iranian Adolescent Girls.

    abstract::Zinc deficiency, which is common among Iranian populations, is believed to play a crucial role in the onset and progression of mood disorders such as depression in different stages of life. We have therefore investigated the relationship between serum/dietary zinc status and depression scores among adolescent girls li...

    journal_title:Biological trace element research

    pub_type: 杂志文章,随机对照试验


    authors: Gonoodi K,Moslem A,Ahmadnezhad M,Darroudi S,Mazloum Z,Tayefi M,Tabatabaeizadeh SA,Eslami S,Shafiee M,Khashayarmanesh Z,Haghighi HM,Ferns GA,Ghayour-Mobarhan M

    更新日期:2018-11-01 00:00:00