Evaluation of allicin for the treatment of experimentally induced subacute lead poisoning in sheep.

Abstract:

:Garlic (Allium sativum) is known to reduce lead toxicity in some species of animals. The objective of this study was to evaluate the efficacy of allicin, one of the most active components of garlic, in the treatment of subacute lead intoxication in sheep. Nine female sheep weighing 25-29 kg orally received a daily dose of 80 mg/kg body weight of lead acetate for 5 days. The animals were then assigned into two groups. Group 1 did not receive any further treatment and was used as the control group and group 2 was treated orally by 2.7 mg/kg body weight of allicin twice daily for 7 days. Within one day following allicin treatment, group 2 blood lead levels were significantly lower than that in group 1 (mean of 616.9 microg/l and 290.02 microg/l, respectively; P < 0.05). Also, allicin treatment significantly reduced kidney lead content and considerably reduced bone and ovary lead contents. These results suggest that allicin might have some therapeutic effects on lead poisoning.

journal_name

Biol Trace Elem Res

authors

Najar-Nezhad V,Aslani MR,Balali-Mood M

doi

10.1007/s12011-008-8185-9

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

141-7

issue

1-3

eissn

0163-4984

issn

1559-0720

journal_volume

126

pub_type

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