Abstract:
:Garlic (Allium sativum) is known to reduce lead toxicity in some species of animals. The objective of this study was to evaluate the efficacy of allicin, one of the most active components of garlic, in the treatment of subacute lead intoxication in sheep. Nine female sheep weighing 25-29 kg orally received a daily dose of 80 mg/kg body weight of lead acetate for 5 days. The animals were then assigned into two groups. Group 1 did not receive any further treatment and was used as the control group and group 2 was treated orally by 2.7 mg/kg body weight of allicin twice daily for 7 days. Within one day following allicin treatment, group 2 blood lead levels were significantly lower than that in group 1 (mean of 616.9 microg/l and 290.02 microg/l, respectively; P < 0.05). Also, allicin treatment significantly reduced kidney lead content and considerably reduced bone and ovary lead contents. These results suggest that allicin might have some therapeutic effects on lead poisoning.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Najar-Nezhad V,Aslani MR,Balali-Mood Mdoi
10.1007/s12011-008-8185-9subject
Has Abstractpub_date
2008-01-01 00:00:00pages
141-7issue
1-3eissn
0163-4984issn
1559-0720journal_volume
126pub_type
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