Investigating the Essentiality and Requirements of Iron from the Ancient to the Present.

Abstract:

:This review discusses the development of studies that evaluated the essentiality and requirements of iron from the ancient to the present. The therapeutic effects of iron compounds were recognized by the ancient Greeks and Romans. The earliest recognition of the essentiality of iron was stated by Paracelsus, a distinguished physician alchemist, in the sixteenth century. Iron was included in the earliest nutritional standard prepared for the Royal Army by E. A. Parkes, the first professor of hygiene. The League of Nations Health Organisation determined average iron requirements based on literature review. In the first US Recommended Dietary Allowances (RDA), the RDA of iron was determined from the results of iron balance studies. In the current Dietary Reference Intakes, iron requirements were determined based on the factorial method with the aid of Monte Carlo simulation for combining basal and menstrual iron losses. Population data analysis is a recently developed alternative that does not use the pre-estimated iron absorption rate and requires the prevalence of inadequacy instead. Population data analysis uses the convolution integral for combining basal and menstrual iron losses to ensure the required accuracy. This review also provides new estimates of hair and nail iron losses.

journal_name

Biol Trace Elem Res

authors

Yokoi K

doi

10.1007/s12011-018-1584-7

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

140-147

issue

1

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-018-1584-7

journal_volume

188

pub_type

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